Testosterone-retinoic acid signaling directs spermatogonial differentiation and seasonal spermatogenesis in the Plateau pika (Ochotona curzoniae)

Wang, Yujun; Jia, Gong-Xue; Yan, Ruiqi; Guo, Sheng‐Ping; Tian, Fei; Ma, Jianbin; Zhang, Ruina; Zhang, Liangzhi; Du, Yurong; Yang, Qi-En

doi:10.1016/j.theriogenology.2018.09.033

Cited by 19 publications

(12 citation statements)

References 44 publications

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“…34 On the other hand, TE has been reported as the key upstream signal that controls RA biogenesis by promoting the expression of genes encoding RA synthesizing enzymes. 35 Our results indicate that RA may function upstream of steroid hormone metabolism in seahorses as demonstrated by the consistent decrease in levels of upstream molecules of steroid hormone metabolism with RA during pregnancy (Figures 2F and 3A). Therefore, PRL, PR, and TE play important roles in the maintenance of brood pouch structure and function of brood pouch.…”

Section: Discussionsupporting

confidence: 68%

Regulatory Role of Retinoic Acid in Male Pregnancy of the Seahorse

Qin

et al. 2020

The Innovation

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Section: Discussionsupporting

confidence: 68%

Regulatory Role of Retinoic Acid in Male Pregnancy of the Seahorse

Qin

et al. 2020

The Innovation

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“…RA is a derivative of vitamin A, synthesized from chemicals such as retinal that are ingested or formed from other vitamins already present within the body. 12 Critically, RA plays an essential role in development, growth and differentiation throughout life. Importantly, for gonadal function and sperm production, in particular, RA is required for spermatogonia to differentiate into spermatozoa.…”

Section: Discussionmentioning

confidence: 99%

“… 11 Furthermore, RA promotes the meiotic process by inducing pachytene arrest in the first meiotic prophase. 12 The spermatogonium goes on a long journey to mature spermatozoa. During this process, immature germ cells undergo differentiation and transformation by RA in each stage.…”

Section: Discussionmentioning

confidence: 99%

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A systematic review of retinoic acid in the journey of spermatogonium to spermatozoa: From basic to clinical application

2022

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Background: Retinoic acid plays an essential role in testicular development and functions, especially spermatogenesis. We have reviewed the role of retinoic acid from basic (molecular) to clinical application. Methods: A search was conducted in the online database including PubMed, Google Scholar, and Scopus for English studies published in the last eight years about this issue. We used the Preferred Reporting Items for Systematic Reviews and Meta-Analyses (PRISMA) guidelines in assessing the studies we are going to investigate. Results: Studies indicated that retinoic acid plays an essential role during pluripotent stem cell migration and lineage commitment, cell differentiation, apoptosis, stem cell number regulation, and maturation arrest in spermatogenic cells. Retinoic acid can also affect related protein expression and signaling pathways at different stages of spermatogenesis. Four studies have applied retinoic acid to humans, all of them in the single-arm observational study. The results look promising but need further research with more controlled study methods, randomization, and large samples. Conclusions: This current systematic review emphasizes a novel retinoic acid mechanism that has not been well described in the literature previously on its functions during the first seven days of spermatogenesis, leading to new directions or explanations of male infertility cause and treatments as a part of reproductive health care.

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“…RNA isolation and quantitative RT-PCR were performed as previously described [20]. RNA samples were isolated using a Trizol reagent (Invitrogen, Carlsbad, CA, USA).…”

Section: Quantitative Rt-pcrmentioning

confidence: 99%

Ring 1 and YY1 Binding Protein is Expressed in Murine Spermatocytes but Dispensable for Spermatogenesis

Yan

Zhang

et al. 2020

Genes

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Spermatogenesis is a complex cellular-differentiation process that relies on the precise regulation of gene expression in spermatogonia, meiotic, and postmeiotic germ cells. The Ring 1 and YY1 binding protein (Rybp) is a member of the mammalian polycomb-group (PcG) protein family that plays multifunctional roles in development. Previous findings indicate that Rybp may function as an important regulator of meiosis. However, its expression in the testes and function in spermatogenesis have not been examined. In this study, we investigated Rybp expression in postnatal mouse testes using qRT-PCR and immunohistochemistry. We also examined the function of Rybp in spermatogenesis by using a conditional-knockout approach. Results showed that the relative expression of Rybp mRNA was significantly upregulated in the testes of postnatal day (PD) 6 mice. Immunofluorescent staining revealed that Rybp was enriched in the spermatocytes. Surprisingly, a conditional deletion of Rybp in fetal germ cells did not affect the fertility or normal development of spermatogenic cells. Further analysis revealed that Rybp deletion resulted in a decreased expression of meiosis-related genes, but that meiosis progression was normal. Together, these findings suggest that Rybp expression was enriched in spermatocytes, but that it was not required for spermatogenesis.

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Testosterone-retinoic acid signaling directs spermatogonial differentiation and seasonal spermatogenesis in the Plateau pika (Ochotona curzoniae)

Cited by 19 publications

References 44 publications

Regulatory Role of Retinoic Acid in Male Pregnancy of the Seahorse

Regulatory Role of Retinoic Acid in Male Pregnancy of the Seahorse

A systematic review of retinoic acid in the journey of spermatogonium to spermatozoa: From basic to clinical application

Ring 1 and YY1 Binding Protein is Expressed in Murine Spermatocytes but Dispensable for Spermatogenesis

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