Testosterone replacement therapy by testosterone ointment relieves lower urinary tract symptoms in late onset hypogonadism patients

Amano, Toshiyasu; Imao, Tetsuya; Takemae, Katsuro; Iwamoto, Teruaki; Nakanome, Mariko

doi:10.3109/13685538.2010.487552

Cited by 50 publications

(29 citation statements)

References 36 publications

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“…Testosterone has been shown to interact with endothelial NOS expressed in pelvic vessels, and consequently improve pelvic blood flow [23]. Some recent reports suggested that TRT may contribute to improving LUTS/OAB in men with LOH syndrome and BPH [8,9]. However, whether the greater increase in TT by dutasteride administration may have a potential role in LUTS and OAB under conditions of strongly suppressed DHT level has not been clarified.…”

Section: Discussionmentioning

confidence: 97%

“…Prostate volume is known to increase along with the progressive decline in testosterone level from middle age, reflecting the evolution of BPH and LUTS. Some recent studies suggested that testosterone levels may be significantly correlated with LUTS, and that TRT can contribute to improvement of LUTS/OAB in men with LOH syndrome and BPH [8,9].…”

Section: Introductionmentioning

confidence: 98%

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Effects of dutasteride on lower urinary tract symptoms and general health in men with benign prostatic hypertroplasia and hypogonadism: a prospective study

et al. 2013

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Section: Discussionmentioning

confidence: 97%

Section: Introductionmentioning

confidence: 98%

Effects of dutasteride on lower urinary tract symptoms and general health in men with benign prostatic hypertroplasia and hypogonadism: a prospective study

et al. 2013

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“…Because testosterone deficiency plays a key role in LOH, testosterone replacement therapy has been used to alleviate the symptoms of LOH. 5,8,9,32 To reveal the mechanism of decreased testosterone production in aged Leydig cells and possibly identify new therapies, we studied the effect of autophagic alteration on steroidogenesis in young and aged rat Leydig cells and TM3 mouse Leydig cells.…”

Section: Discussionmentioning

confidence: 99%

“…3 And testosterone replacement therapy can alleviate the symptoms and signs with a wide range of benefits that include improvement in libido and sexual function, bone density, muscle mass, body composition, mood, erythropoiesis, cognition, quality of life and cardiovascular disease. 2,[4][5][6][7][8] Serum testosterone levels decrease in aged males, and dysfunction of the aged Leydig cells might plays a key role in this process. [9][10][11] Androgen is mainly produced by Leydig cells and many enzymes, such as steroidogenic acute regulatory (StAR) protein, cholesterol sidechain cleavage enzyme (P450scc) and 3b-hydroxysteroid dehydrogenase, are involved in regulation of testosterone production.…”

Section: Introductionmentioning

confidence: 99%

Autophagic deficiency is related to steroidogenic decline in aged rat Leydig cells

Li¹,

Chen²,

Chen³

et al. 2011

Asian J Androl

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Late-onset hypogonadism (LOH) is closely related to secondary androgen deficiency in aged males, but the mechanism remains unclear. In this study, we found that reduced testosterone production in aged rat Leydig cells is associated with decreased autophagic activity. Primary rat Leydig cells and the TM3 mouse Leydig cell line were used to study the effect of autophagic deficiency on Leydig cell testosterone production. In Leydig cells from young and aged rats, treatment with wortmannin, an autophagy inhibitor, inhibited luteinising hormone (LH)-stimulated steroidogenic acute regulatory (StAR) protein expression and decreased testosterone production. In contrast, treatment with rapamycin, an autophagy activator, enhanced LH-stimulated steroidogenesis in Leydig cells from aged, but not young, rats. Intracellular reactive oxygen species (ROS) levels were increased in both young and aged Leydig cells treated with wortmannin but decreased only in aged Leydig cells treated with rapamycin. Furthermore, an increased level of ROS, induced by H 2 O 2 , resulted in LH-stimulated steroidogenic inhibition. Finally, knockdown of Beclin 1 decreased LH-stimulated StAR expression and testosterone production in TM3 mouse Leydig cells, which were associated with increased intracellular ROS level. These results suggested that autophagic deficiency is related to steroidogenic decline in aged rat Leydig cells, which might be influenced by intracellular ROS levels.

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“…Thus, it has been speculated that TRT with Glowmin may be effective in the improvement of not only erectile dysfunction and TDS symptoms but also lower urinary tract symptoms (especially voiding disturbance) in Japanese patients with TDS. 56 No recommendations as to the duration of TRT have been made in the guidelines of the International Society of Andrology, the International Society for the Study of the Aging Male or the European Association of Urology. 57 If a patient with TDS does not benefit from TRT, discontinuation of TRT is accepted without question.…”

Section: Testosterone Treatment For Tdsmentioning

confidence: 99%

Recent topics related to testosterone deficiency syndrome in Japan

Tsujimura¹,

Nonomura²

2011

Asian J Androl

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Androgens, the levels of which decrease with ageing, play many physiological roles in various organs. Testosterone deficiency syndrome (TDS) has received widespread attention in the last several years. First-line treatment for TDS should be testosterone replacement therapy (TRT), which is reported to improve several TDS symptoms. Recently, a clinical practice manual for TDS was written and published by a collaborative team from the Japanese Urological Association and the Japanese Society for the Study of the Aging Male to recommend standard procedures for the diagnosis, treatment, prevention and monitoring of adverse reactions to TRT and for post-treatment assessment. In this manual, intramuscular injection of testosterone enanthate or human chorionic gonadotropin and the testosterone gel 'Glowmin' were recommended as TRT. Currently, two topics related to TDS are being focused on in Japan: the relationship between TDS and metabolic syndrome and treatment options for eugonadal patients with TDS symptoms. In this review, the possibility of TRT for metabolic syndrome as well as the relationship between testosterone and adiponectin, which is a key molecule in metabolic syndrome, is discussed. Finally, the possibility of herbal medicines as a treatment option for patients with TDS is addressed, especially for eugonadal patients, because eugonadal men with TDS symptoms account for approximately 30% of the general population. The increase in the levels of several cytokines, such as IL-8, IL-13, interferon-c and tumor necrosis factor-a, after herbal medicine treatment may be the reason for this efficacy.

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Testosterone replacement therapy by testosterone ointment relieves lower urinary tract symptoms in late onset hypogonadism patients

Abstract: TRT by administration of GL is considered to be effective in the improvement of not only ED and LOH symptoms, but also LUTS (especially voiding disturbance) of patients with LOH.

Cited by 50 publications

References 36 publications

Effects of dutasteride on lower urinary tract symptoms and general health in men with benign prostatic hypertroplasia and hypogonadism: a prospective study

Effects of dutasteride on lower urinary tract symptoms and general health in men with benign prostatic hypertroplasia and hypogonadism: a prospective study

Autophagic deficiency is related to steroidogenic decline in aged rat Leydig cells

Recent topics related to testosterone deficiency syndrome in Japan

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