Testosterone replacement in the infertile man

Majzoub, Ahmad; Sabanegh, Edmund

doi:10.21037/tau.2016.08.03

Cited by 16 publications

(13 citation statements)

References 43 publications

(45 reference statements)

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“…Beyond their clear indication in the treatment of breast cancer, aromatase inhibitors might be useful for men in the treatment of infertility or gynecomastia induced during testosterone supplementation . One of the potential applications of aromatase inhibitors in men might be the treatment of hypogonadism, providing an alternative to testosterone supplementation, which leads to numerous clinically relevant side effects including erythrocytosis and hyperestrogenism . Unlike testosterone supplementation, aromatase inhibitor treatment preserves fertility.…”

Section: Introductionmentioning

confidence: 99%

Sex‐dependent effects of letrozole on anxiety in middle‐aged rats

Borbélyová

Domonkos

Csongová

et al. 2017

Clin Exp Pharma Physio

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Aromatase catalyzes the conversion of testosterone to estradiol and is involved in the physiological effects of sex hormones on brain function. Animal experiments have shown that the aromatase inhibitor, letrozole, can induce anxiety in young ovariectomized females that are used as a model of aging. Whether or not these effects would be similar in intact middle-aged animals is unknown. The aim of our study was to analyze the effects of letrozole on anxiety in middle-aged rats of both sexes. Fifteen month old male and female rats were treated daily with either letrozole or vehicle for 2 weeks. The elevated plus maze was used to test anxiety-like behaviour. Sex differences were found not only in plasma concentrations of testosterone but also in the effects of letrozole treatment on plasma testosterone (P<.05). The interaction between sex and treatment was also proven in locomotor activity (P<.05) and time spent in the open arms of the elevated plus maze (P<.05). Letrozole-treated male rats spent 95% less time in the open arms of the elevated plus maze than the control rats did (P<.05) suggesting an anxiogenic effect of aromatase inhibition. This difference was not found between letrozole-treated and vehicle-treated females. In contrast to previous experiments on young animals, letrozole seems to induce anxiety in male but not in female middle-aged rats. This sex-specific effect might be related to sex differences of oestrogen and androgen signalling in aging brains. These results should be taken into account in clinical applications of letrozole, especially in men.

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Section: Introductionmentioning

confidence: 99%

Sex‐dependent effects of letrozole on anxiety in middle‐aged rats

Borbélyová

Domonkos

Csongová

et al. 2017

Clin Exp Pharma Physio

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“…Excessive increase in testosterone can directly affect Sertoli cells to secrete inhibin which will act directly towards the anterior pituitary. Testosterone can aromatize to estradiol, which exerts negative feedback on the hypothalamus and pituitary gland (Majzoub and Sabaneghjr, 2016) because, in the hypothalamus, there are androgen and estrogen receptors (Tilbrook and Clarke, 2001).The decrease that occurs due to negative feedback is not too signi icant according to the results of statistical analysis. Comparison between the concentration of spermatozoa in group 3 and group 2 also had insignificant differences.…”

Section: Resultsmentioning

confidence: 99%

Kebar grass (Biophytum petersianum K.) The effect inmaintaining mice (Mus musculus) sperm quality exposed to dioxin

Labib¹,

Widjiati²,

Hernawati³

et al. 2020

ijrps

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Kebar grass contains active antioxidants and potential vitamins to neutralize TCDD toxicity. Prove that Kebar grass extract in various dosage can maintain viability, motility, and sperm concentration of male mice exposed to 2,3,7,8-tetrachlorodibenzo-p-dioxin. This study was an experimental laboratory study with five groups consists of Negative Control (C-), Positive Control (K +) with TCDD exposure of 0.7μg/Kg BW IP single dose. The treatment group was given oral Kebar grass extract for 53 days treatment 1 (T1) with a dose of 0.045 mg / g BB, Treatment 2 (T2) with a dose of 0.08 mg/g/BW, and Treatment 3 (T3) with a dose of 0.135 mg/g/BW. The data of motility, viability, and concentration of spermatozoa obtained were analyzed using One Way Anova test and Duncan Multiple Range Test. Administration of Kebar Grass Extract at a dosage of 0.135 mg/g/BW showed a significant difference between the control group and the treatment group (p<0.05). Exposure to TCDD in C+ decreased motility (13 ± 6.70%), viability (28 ± 19.35%), and concentration (0.87 ± 0.64 cells / mm3) of sperm significantly compared to C-. The administration of Kebar grass extract can maintain motility (74 ± 5.47%), viability (76 ± 2.72%), and concentration (2.50 ± 0.69 cells/mm3) spermatozoa in the T3 group with a dose of 0.135mg/g/BW. Kebar grass extract is effective for maintaining the quality of mice sperm from damage due to exposure to 2,3,7,8-tetrachlorodibenzo-p-dioxin.

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“…If the patient wishes to preserve fertility, treatment options other than testosterone should be considered; examples include clomiphene citrate, human menopausal gonadotropin, and human chorionic gonadotropin. 23,24 Our patient has no desire to expand his family; therefore, a semen analysis and attempts to preserve spermatogenesis are not indicated.…”

Section: History Of Androgenic Anabolic Steroid Usementioning

confidence: 99%