Testosterone Propionate Exacerbates the Deficits of Nigrostriatal Dopaminergic System and Downregulates Nrf2 Expression in Reserpine-Treated Aged Male Rats

Cui, Rui; Kang, Yunxiao; Wang, Li; Li, Shuangcheng; Ji, Xiaoming; Yan, Wensheng; Zhang, Guoliang; Cui, Huixian; Shi, Geming

doi:10.3389/fnagi.2017.00172

Cited by 18 publications

(23 citation statements)

References 64 publications

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“…Oxidative stress is one of the most significant factors that causes dopaminergic system disturbances. The factor, aging, leads to dopamine auto-oxidation [9] and testosterone may enhance oxidative stress-related neurotoxicity in dopaminergic neurons and then lead to apoptosis [15]. Furthermore, it has been demonstrated that short-term and long-term stress may cause the reduction of blood testosterone levels and modified oxidative redox [13].…”

Section: Testosterone and Oxidative Stressmentioning

confidence: 99%

“…Moreover, it was reported that there was a positive correlation between the quantity of spicy food (eating behavior) and endogenous salivary testosterone [8]. Testosterone may regulate the behaviors of organisms by affecting central dopaminergic system [9]. Testosterone affects brain functions including motor, cognitive, and motivational behaviors and dopamine release in midbrain circuits [10].…”

Section: Testosterone and Dopaminergic Systemmentioning

confidence: 99%

“…It has been reported that testosterone supplements might improve the symptoms (motor) in Parkinson's Disease, and motor behavior deficiences in aged male rats and castrated male rats, and activate dopaminergic system [9]. The activated dopaminergic system by testosterone supplements may be associated with the decreased oxidative stress [9]. Meydan et al has demonstrated that testosterone as a neuroprotective agent suppresses orchiectomyinduced oxidative damage [24].…”

Section: Testosterone Treatment For Neurodegenerative Diseasesmentioning

confidence: 99%

“…Meydan et al has demonstrated that testosterone as a neuroprotective agent suppresses orchiectomyinduced oxidative damage [24]. Furthermore, the decreased levels of dopamine, tyrosine hydroxylase and dopamine transporters in old male rats are enhanced by testosterone supplements [9].…”

Section: Testosterone Treatment For Neurodegenerative Diseasesmentioning

confidence: 99%

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Is testosterone perspective available for neurodegenerative diseases?

Avşar¹

2018

Neuropsychiatry

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Neurodegenerative diseases such as Parkinson's disease and Alzheimer's disease are increasingly spreading worldwide. Neuroinflammation, deposition of misfolded proteins, oxidative stress, mitochondrial dysfunction, and excitotoxicity are main biological processes in the development of neurodegeneration. Furthermore, noncoding RNAs, genetic mutations, and environmental factors are involved in the development of neurodegeneration. Recent advances in the knowledge of testosterone shows that the concentrations of testosterone might be effective in the pathogenesis of the neurodegenerative diseases and testosterone has been implicated in the modulation of dopaminergic system. It has been proposed that the degree of the oxidative stress identifies whether testosterone affects neuronal function negatively or positively. In other words, testosterone can be neurotoxic or neuroprotective according to the environment. In the light of several evidences, testosterone should be evaluated as a crucial factor for the prevention, diagnosis, and treatment of neurodegenerative diseases by clinicians.

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Section: Testosterone and Oxidative Stressmentioning

confidence: 99%

Section: Testosterone and Dopaminergic Systemmentioning

confidence: 99%

Section: Testosterone Treatment For Neurodegenerative Diseasesmentioning

confidence: 99%

Section: Testosterone Treatment For Neurodegenerative Diseasesmentioning

confidence: 99%

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Is testosterone perspective available for neurodegenerative diseases?

Avşar¹

2018

Neuropsychiatry

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“…Besides, long-term use of reserpine increases cholinergic tonus; and by suppressing adrenergic activity, it leads to gastric mucosal lesion with an increase in gastric acid production and motility (6). Some studies indicate that reserpine has strong oxidant activity in plasma and tissues (7)(8)(9). In spite of all these effects, reserpine is still used in China as it is more effective and cheaper along with other hypotensive drugs such as compound hypotensive tablets (CHTs) and compound reserpine tablets (5).…”

Section: Introductionmentioning

confidence: 99%

Effects Of Thymoquinone and Citalopram On Oxidative Stress in Gastric and Duodenum Tissue in Reserpinized Rats

Kuzay¹

2019

Erciyes Med J

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Objective: Medicaments used in the therapy of GIS diseases have many detrimental impacts. Therefore, antioxidant effective molecules can help in the treatment process. This study aimed to examine the oxidant and antioxidant activity of thymoquinone (TQ) and citalopram in gastric and duodenum tissues of reserpinized rats. Materials and Methods: In the study, we split the rats in six groups of six rats each: 1) Control (C) 1; 2) Control (C) 2; 3) reserpine (R); 4) Reserpine+citalopram (R+C); 5) Reserpine+thymoquinone (R+T); 6) Reserpine+citalopram+thymoquinone (R+C+T). Reserpine (0.2 mg/kg) was intraperitoneally administered. TQ (10 mg/kg) and citalopram (10 mg/kg) were intragastrically administered 30 min before reserpine injection. The rats were treated for 14 consecutive days. At the end of the experiment, we examined total antioxidant status and total oxidant status in gastric tissue; and total nitric oxide, malondialdehyde, and glutathione levels in duodenum tissue. Results: There was a reduction on total oxidant status in gastric tissue in the R+C group in comparison with the R group (p<0.01). The decrease in total oxidant status in the R+C+T and R+T groups was more significant (p<0.01). An increase in total antioxidant status was observed in the R+C, R+T, and R+C+T groups when compared to the R group (p<0.01). In comparison to the R group, there was a reduction in malondialdehyde and nitric oxide levels and a rise in glutathione level in duodenum tissue in the R+C+T and R+T groups (p<0.01). Conclusion: Reserpine increased oxidative stress and decreased antioxidant capacity in gastric and duodenum tissues. TQ and citalopram+TQ treatment decreased oxidative stress and increased antioxidant capacity in gastric and duodenum tissues. TQ and citalopram+TQ treatments proved to be more effective in protection from oxidative stress caused by reserpine in gastric and duodenum tissues than citalopram treatment.

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