Testosterone levels mediate the dynamics of motor oscillatory coding and behavior in developing youth

Killanin, Abraham D.; Taylor, Brittany K.; Embury, Christine M.; Picci, Giorgia; Wang, Yuping; Calhoun, Vince D.; Stephen, Julia M.; Heinrichs‐Graham, Elizabeth; Wilson, Tony W.

doi:10.1016/j.dcn.2023.101257

Cited by 4 publications

(2 citation statements)

References 51 publications

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“…The higher connectivity of age 12 males than females of the same age can be associated with the higher secretion levels of DHEAS and testosterone in males between 6 and 13 years old than in females [33]. The increased node strength in the male group over the female group of the same age could be attributed to these hormones as well, since testosterone has been related to neural and behavioral indices of complex motor cortical dynamics and performance [39,40].…”

Section: Discussionmentioning

confidence: 99%

Sex-Related Variations in the Brain Motor-Network Connectivity at Rest during Puberty

Pacheco-Blas,

González-González,

Ortega-Aguilar

2023

Applied Sciences

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The development of functional neuroimaging technologies has resulted in a flood of mathematical models that investigate functional brain connections in health and disease. Motor network activity in the resting state and its response to puberty remains to be investigated. Variations between sexes in puberty may appear not just in brain regions involved in sexual and emotional activities, but also in cognitive and motor abilities that are active even when the individual is resting. The aim of this study was to investigate the interactions of the motor subnetwork in the resting state of healthy males and females aged 12 and 16. This study used the OpenNeuro Dataset ds004169:1.0.7, Queensland Twin IMaging. The MRI signals were preprocessed to get adjacency matrices from the sensory/somatomotor and cerebellar networks in the Power atlas. Network topology was analyzed using the centrality measures of strength, hubness, and leverage. The strength of the nodes increases with age in both sex groups. Both sexes had right hemisphere dominance in the cerebellar-mouth subnetwork and left dominance in the cerebellar-hand subnetwork. Eleven leverage centrality regions were common to all groups, the most relevant were the Precuneus, the cingulum postcentral and the supplementary motor area. In both sexes, hubs at age 12 were detected only in the right hemisphere. This dominance was reduced at age 16. Understanding connectivity changes in the brain during rest may enable the identification of neurophysiological mechanisms of cognitive and behavioral development that may contribute to long-term psychological well-being in adolescents.

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Section: Discussionmentioning

confidence: 99%

Sex-Related Variations in the Brain Motor-Network Connectivity at Rest during Puberty

Pacheco-Blas,

González-González,

Ortega-Aguilar

2023

Applied Sciences

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“…Other studies have found testosterone to mediate the relationship between age and the beta oscillations serving motor control (Killanin et al, 2023) and sensorimotor processing more broadly (Fung et al, 2022) in the primary motor cortices. Furthermore, in developing youth, testosterone's relationship with spontaneous cortical activity has been found to differ by sex, with the strongest differences in frontal cortices .…”

Section: Introductionmentioning

confidence: 91%

Effects of endogenous testosterone on oscillatory activity during verbal working memory in youth

Killanin,

Ward,

Embury

et al. 2024

Human Brain Mapping

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Testosterone levels sharply rise during the transition from childhood to adolescence and these changes are known to be associated with changes in human brain structure. During this same developmental window, there are also robust changes in the neural oscillatory dynamics serving verbal working memory processing. Surprisingly, whereas many studies have investigated the effects of chronological age on the neural oscillations supporting verbal working memory, none have probed the impact of endogenous testosterone levels during this developmental period. Using a sample of 89 youth aged 6–14 years‐old, we collected salivary testosterone samples and recorded magnetoencephalography during a modified Sternberg verbal working memory task. Significant oscillatory responses were identified and imaged using a beamforming approach and the resulting maps were subjected to whole‐brain ANCOVAs examining the effects of testosterone and sex, controlling for age, during verbal working memory encoding and maintenance. Our primary results indicated robust testosterone‐related effects in theta (4–7 Hz) and alpha (8–14 Hz) oscillatory activity, controlling for age. During encoding, females exhibited weaker theta oscillations than males in right cerebellar cortices and stronger alpha oscillations in left temporal cortices. During maintenance, youth with greater testosterone exhibited weaker alpha oscillations in right parahippocampal and cerebellar cortices, as well as regions across the left‐lateralized language network. These results extend the existing literature on the development of verbal working memory processing by showing region and sex‐specific effects of testosterone, and are the first results to link endogenous testosterone levels to the neural oscillatory activity serving verbal working memory, above and beyond the effects of chronological age.

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The future of psychophysiology, then and now

Marder,

Miller

2024

Biological Psychology

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Testosterone levels mediate the dynamics of motor oscillatory coding and behavior in developing youth

Cited by 4 publications

References 51 publications

Sex-Related Variations in the Brain Motor-Network Connectivity at Rest during Puberty

Sex-Related Variations in the Brain Motor-Network Connectivity at Rest during Puberty

Effects of endogenous testosterone on oscillatory activity during verbal working memory in youth

The future of psychophysiology, then and now

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