Testosterone is associated with insulin resistance index independently of adiposity in women with polycystic ovary syndrome

Luotola, Kari; Piltonen, Terhi; Puurunen, Johanna; Morin‐Papunen, Laure; Tapanainen, Juha S.

doi:10.1080/09513590.2017.1342793

Cited by 18 publications

(13 citation statements)

References 31 publications

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“…232 Moderate elevation of T concentrations with obesity involved in inflammatory factors can control glucose homeostasis via raising IR and earlier insulin secretion. 262 T treatment in men with T2DM and hypogonadotropic hypogonadism increases insulin sensitivity and together decreases circulating levels of inflammation markers. 263 T directly and indirectly (via growth hormone stimulation) decreases inflammation levels in adipose tissue and thus protecting the role against IR.…”

Section: Inflammationmentioning

confidence: 98%

The Effects of Androgens on Cardiometabolic Syndrome: Current Therapeutic Concepts

et al. 2020

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Introduction: Cardiometabolic syndrome (CMS), as a bunch of metabolic disorders mainly characterized by type 2 diabetes mellitus (T2DM), hypertension, atherosclerosis, central adiposity, and abdominal obesity triggering androgen deficiency, is one of the most critical threats to men. Although many significant preclinical and clinical findings explain CMS, new approaches toward common pathophysiological mechanisms and reasonable therapeutic targets are lacking. Aim: To gain a further understanding of the role of androgen levels in various facets of CMS such as the constellation of cardiometabolic risk factors including central adiposity, dyslipidemia, insulin resistance, diabetes, and arterial hypertension and to define future directions for development of effective therapeutic modalities. Methods: Clinical and experimental data were searched through scientific literature databases (PubMed) from 2009 to October 2019. Main Outcome Measure: Evidence from basic and clinical research was gathered with regard to the causal impact and therapeutic roles of androgens on CMS. Results: There are important mechanisms implicated in androgen levels and the risk of CMS. Low testosterone levels have many signs and symptoms on cardiometabolic and glycometabolic risks as well as abdominal obesity in men. Clinical Implications: The implications of the findings can shed light on future improvements in androgen levels and add potentially predictive risk for CMS, as well as T2DM, abdominal obesity to guide clinical management in the early stage. Strengths & Limitations: This comprehensive review refers to the association between androgens and cardiovascular health. A limitation of this study is the lack of large, prospective population-based studies that analyze the effects of testosterone treatment on CMS or mortality. Conclusion: Low testosterone levels have several common features with metabolic syndrome. Thus, testosterone may have preventive role in the progress of metabolic syndrome and subsequent T2DM, abdominal obesity, and cardiovascular disease and likely affect aging men's health mainly through endocrine and vascular mechanisms. Further studies are necessary to evaluate the therapeutic interventions directed at preventing CMS in men. Kirlangic OF, Yilmaz-Oral D, Kaya-Sezginer E, et al. The Effects of Androgens on Cardiometabolic Syndrome: Current Therapeutic Concepts. Sex Med 2020;8:132e155.

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Section: Inflammationmentioning

confidence: 98%

The Effects of Androgens on Cardiometabolic Syndrome: Current Therapeutic Concepts

et al. 2020

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“…PCOS directly affects body composition and anthropometric indices, as well as endocrine, metabolic, and cardiovascular system parameters (1)(2)(3)(4)(5). Central obesity is also a prevalent characteristic because of hyperandrogenism and insulin resistance (IR), which act in vicious feedback mechanisms (6,7). However, abdominal fat may go undetected in women of normal weight who exhibit an apparently lean PCOS (6,7), predisposing them to risk factors for chronic diseases, such as metabolic syndrome and arterial hypertension (1,(4)(5).…”

Section: Introductionmentioning

confidence: 99%

“…Central obesity is also a prevalent characteristic because of hyperandrogenism and insulin resistance (IR), which act in vicious feedback mechanisms (6,7). However, abdominal fat may go undetected in women of normal weight who exhibit an apparently lean PCOS (6,7), predisposing them to risk factors for chronic diseases, such as metabolic syndrome and arterial hypertension (1,(4)(5). The prevalence of metabolic syndrome among individuals with PCOS is 12.6%, which is almost seven times higher than that in healthy women with a higher body mass index (BMI) (8).…”

Section: Introductionmentioning

confidence: 99%

Association of measures of central fat accumulation indices with body fat distribution and metabolic, hormonal, and inflammatory parameters in women with polycystic ovary syndrome

Ribeiro¹,

Kogure²,

Lopes³

et al. 2019

Archives of Endocrinology and Metabolism

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Objective: To investigate the associations among visceral adiposity index (VAI), lipid accumulation product (LAP), body fat percentage (%), and android/gynoid ratio (A/G ratio) in women with polycystic ovary syndrome (PCOS) and verify if the parameters representative of visceral obesity correlate with and exhibit the same frequency as body composition variables; anthropometric indices; and metabolic, hormonal, and inflammatory parameters. Subjects and methods: This was a cross-sectional study that included 94 women with PCOS. Hormonal, metabolic, and inflammatory parameters were analyzed in all women. Free androgen index (FAI) and homeostasis model assessment (HOMA-IR), as well as LAP, VAI, and anthropometric indices, were calculated. The regions of interest (ROIs) in body composition and body composition indices were evaluated using a dual X-ray absorptiometry (DXA). Overall, 32 variables were selected as markers of body fat distribution. Results: Among the 32 markers evaluated, 29 correlated with LAP, whereas 25 correlated with VAI, 19 with body fat (%), and 30 with A/G ratio. Additionally, some markers correlated with the four adiposity indices evaluated: ROIs, except for total mass and leg fat (%); body composition (body mass index, waist circumference, and hip circumference) indices; fasting insulin; and C-reactive protein. Conclusion: LAP and VAI may be sensitive measures for screening and preventing metabolic syndrome and insulin resistance in PCOS, with LAP being more sensitive than VAI, and the A/G ratio may be more sensitive than body fat percentage.

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“…O mesmo ocorre na presença de menores níveis de globulina ligadora de hormônios sexuais -sex hormone binding globulin (SHBG) (CASSAR et al, 2016). Além disso, o hiperandrogenismo está relacionado a índices de RI tanto em mulheres com SOP magras quanto em sobrepeso e obesas (HUANG et al, 2015;LUOTOLA et al, 2018). Também, já foi descrito que a hiperinsulinemia pode contribuir para o incremento hiperandrogênico, havendo, portanto, um circuito de alimentação e retroalimentação (GRAHAM e SELGRADE, 2017).…”

Section: Figura 1 -Ovário Policísticounclassified

“…Apesar disto, sugerimos que o conjunto das mudanças do padrão antropométrico, sobretudo da redução da CC em ambos os grupos AI e AC, e da relação cintura-quadril no grupo AI e CQ no grupo AC, além da redução do colesterol e LDL no grupo AC, tenham sido fatores preponderantes para melhoria do perfil androgênico, visto que outros estudos demonstraram que há relação positiva entre altas taxas de testosterona e FAI com a obesidade abdominal e central aumentada (KLISIC et al, 2017;MORAN et al, 2017;PINOLA et al, 2017). Adicionalmente, o hiperandrogenismo produz efeito cascata aumentando o risco de disfunção cardiovascular, além de predispor à RI (YILMAZ et al, 2015;LUOTOLA et al, 2018).…”

Section: Efeitos Do Treinamento Físico -Hormônios Sexuaisunclassified

Efeitos do treinamento físico aeróbio contínuo e intermitente sobre parâmetros endócrino-metabólicos, composição corporal e comprimento do telômero em mulheres com síndrome dos ovários policísticos: ensaio clínico controlado

Ribeiro¹

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Testosterone is associated with insulin resistance index independently of adiposity in women with polycystic ovary syndrome

Abstract: Moderately elevated testosterone concentrations together with obesity-related inflammatory factors modify glucose homeostasis by increasing insulin resistance and early insulin secretion.

Cited by 18 publications

References 31 publications

The Effects of Androgens on Cardiometabolic Syndrome: Current Therapeutic Concepts

The Effects of Androgens on Cardiometabolic Syndrome: Current Therapeutic Concepts

Association of measures of central fat accumulation indices with body fat distribution and metabolic, hormonal, and inflammatory parameters in women with polycystic ovary syndrome

Efeitos do treinamento físico aeróbio contínuo e intermitente sobre parâmetros endócrino-metabólicos, composição corporal e comprimento do telômero em mulheres com síndrome dos ovários policísticos: ensaio clínico controlado

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