Testosterone is an independent determinant of bone mineral density in men with type 2 diabetes mellitus

Василькова, О. Н.; Mokhort, Tatiana; Sanec, Igor; Шаршакова, Т. М.; Hayashida, Naomi; Takamura, Noboru

doi:10.1515/cclm.2011.016

Cited by 7 publications

(3 citation statements)

References 39 publications

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“…In males, free testosterone, SHBG and total testosterone were different with regard to correlation with BMD in most studies. [20][21][22] Similar results were found in females. 23 We speculated that total testosterone and estradiol used in the current study may partially explain the differences in our findings from other studies.…”

Section: Discussionsupporting

confidence: 83%

Microangiopathy is associated with bone loss in female type 2 diabetes mellitus patients

Zhong

Zhang

et al. 2018

Diabetes and Vascular Disease Research

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Objective: Type 2 diabetes mellitus complicated with microvascular diseases can be used as a model to study the relationship between bone health and the microvascular situation. Methods: A total of 2,170 patients with type 2 diabetes mellitus (1,188 postmenopausal females and 982 males aged ⩾50 years) were included in our cross-sectional study. These patients were grouped according to 24-hour urine protein level: Group I (<30 mg), Group II (30-299 mg) and Group III (≥300 mg). Bone mineral density of the lumbar spine, hip and femoral neck was evaluated by dual-energy X-ray absorptiometry. Fundus oculi photography for diabetic retinopathy and 24-h urine protein for diabetic nephropathy were used as markers of microangiopathy in type 2 diabetes mellitus. Characteristics of the patients and bone mineral density were compared. Multivariate analysis was used to study the association between bone mineral density and microangiopathy. Statistical analysis was performed using SPSS 20.0. p < 0.05 was considered statistically significant. Results: Group III had the lowest bone mineral density level in both genders. Multivariate analysis revealed that microangiopathy was negatively correlated with bone mineral density in females (lumbar: r = -0.522, p < 0.001; hip: r = -0.301, p = 0.010; femoral neck: r = -0.314, p = 0.009), but not in males, after adjustment for age, body mass index, hypertension, hyperlipidemia, diabetic status, hepatic function, kidney function, sex hormones and 25(OH) vitamin D. Conclusion:These results demonstrate an independent negative correlation between microangiopathy and bone mineral density in postmenopausal female type 2 diabetes mellitus patients.

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Section: Discussionsupporting

confidence: 83%

Microangiopathy is associated with bone loss in female type 2 diabetes mellitus patients

Zhong

Zhang

et al. 2018

Diabetes and Vascular Disease Research

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“…It is not completely clear whether duration of T2DM is associated with BMD. Some studies did not found an association between BMD and duration of the disease [53][54][55], but others did show a negative association [56][57][58][59]. As the studies that were not able to find an association between BMD and duration of the disease did not include any patients with a very long duration (>20 years) of the disease, the lack between an association between BMD and duration of the disease in this studies could be due to population bias.…”

Section: Bone Massmentioning

confidence: 70%

Increased fracture risk in patients with type 2 diabetes mellitus: An overview of the underlying mechanisms and the usefulness of imaging modalities and fracture risk assessment tools

et al. 2014

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Type 2 diabetes mellitus has recently been linked to an increased fracture risk. Since bone mass seems to be normal to elevated in patient with type 2 diabetes, the increased fracture risk is thought to be due to both an increased falling frequency and decreased bone quality. The increased falling frequency is mainly a result of complications of the disease such as a retinopathy and polyneuropathy. Bone quality is affected through changes in bone shape, bone micro-architecture, and in material properties such as bone mineralization and the quality of collagen. Commonly used methods for predicting fracture risk such as dual energy X-ray absorptiometry and fracture risk assessment tools are helpful in patients with type 2 diabetes mellitus, but underestimate the absolute fracture risk for a given score. New imaging modalities such as high resolution peripheral quantitative computed tomography are promising for giving insight in the complex etiology underlying the fragility of the diabetic bone, as they can give more insight into the microarchitecture and geometry of the bone. We present an overview of the contributing mechanisms to the increased fracture risk and the usefulness of imaging modalities and risk assessment tools in predicting fracture risk in patients with type 2 diabetes.

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“…Un estudio realizado en 138 diabéticos tipo 2 mostró que las concentraciones de TL se asociaban directamente con la DMO en miembros superiores y costillas pero no con la de la columna, la cadera, ni con la DMO global (341). Otro trabajo reciente observó correlación significativa entre la TT y TL con la DMO de la columna lumbar y demostró que la TT era un determinante independiente de la DMO en varones con DM tipo 2 (347). Está por determinar la influencia que pueden tener las concentraciones de estradiol sobre la DMO en este grupo de pacientes, ya que los varones con hipogonadismo generalmente tienen concentraciones de estradiol más bajas, debido a que la testosterona es el sustrato para la formación de estradiol (105), y en algunos estudios las concentraciones de estradiol se han relacionado, de forma más robusta que la testosterona, con la DMO en varones (348).…”

Section: Densidad óSeaunclassified

Causas y consecuencias del hipogonadismo en varones con diabetes mellitus tipo 2

Ruiz¹

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INTRODUCCIÓN 1. Eje hipotálamo-hipofisario-testicular 2. Hipogonadismo 2.1. Definición 2.2. Etiología 2.3. Epidemiología 2.4. Clínica 2.5. Diagnóstico 2.6. Testosterona y edad 2.7. Testosterona y enfermedad cardiovascular 2.8. Testosterona y mortalidad 2.9. Screening de hipogonadismo 3. Diabetes e hipogonadismo 3.1. Prevalencia de hipogonadismo en la diabetes 3.2. Predisposición a diabetes 3.3. Etiopatogenia 3.4. Consecuencias del hipogonadismo en la diabetes 3.5. Estudios de intervención en diabetes 2. BASE RACIONAL Y OBJETIVOS Base racional Objetivos 3. MATERIAL Y MÉTODOS 4. RESULTADOS I. Características de la muestra II. Estudio de hipogonadismo en pacientes diabéticos ABREVIATURAS AAI: anticuerpos anti insulina ACV: accidente cerebrovascular ADA: American Diabetes Association ADAM: Androgen Deficiency in Aging Male ADOS: antidiabéticos orales ALT: alanina aminotransferasa AMSS: Aging Male Symptoms Scale ARA 2: antagonista del receptor de la angiotensina II ASA: American Society of Andrology AST: aspartato aminotransferasa BIA: impedancia bioeléctrica CC: circunferencia de cintura Cr: creatinina Ccr: aclaramiento de creatinina CT: colesterol total CV: coeficiente de variación DE: desviación estándar DHEA: dehidroepiandrosterona DHEAS: dehidroepiandrosterona sulfato DHT: dihidrotestosterona DM: diabetes mellitus DMO: densidad mineral ósea

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Testosterone is an independent determinant of bone mineral density in men with type 2 diabetes mellitus

Abstract: Our data indicate that androgens are independent determinants of BMD in male patients with DT2.

Cited by 7 publications

References 39 publications

Microangiopathy is associated with bone loss in female type 2 diabetes mellitus patients

Microangiopathy is associated with bone loss in female type 2 diabetes mellitus patients

Increased fracture risk in patients with type 2 diabetes mellitus: An overview of the underlying mechanisms and the usefulness of imaging modalities and fracture risk assessment tools

Causas y consecuencias del hipogonadismo en varones con diabetes mellitus tipo 2

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