Testosterone Induced Growth of the Oviduct in the Frog, Rana pipiens: Evidence for Local Aromatization

Dubowsky, Sondra Ann.; Smalley, Katherine N.

doi:10.1006/gcen.1993.1033

Cited by 16 publications

(2 citation statements)

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“…The fact that AR is expressed in the human tubal epithelium points to an important role of this hormone in the fallopian tube which is the site of gamete transport, fertilization, and early embryogenesis (Janssen, Brinkmann, Boersma, & Van der Kwast, ). Studies precisely describing the effects of testosterone on the functional morphology of the tube are lacking in humans and mammals; however, there have been studies in the chick and in the frog (Dubowsky, ; Dubowsky & Sammalley, ; Palmiter & Haines, ). In these studies, androgens have been shown to indirectly mediate growth of the tubal cells via conversion to estrogen.…”

Section: Introductionmentioning

confidence: 99%

How do elevated levels of testosterone affect the function of the human fallopian tube and fertility?—New insights

Dulohery

Trottmann

Bour

et al. 2019

Molecular Reproduction Devel

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Excess testosterone levels affect up to 20% of the female population worldwide and are a key component in the pathogenesis of polycystic ovary syndrome. However, little is known about how excess testosterone affects the function of the human fallopian tube-the site of gamete transport, fertilization, and early embryogenesis. Therefore, this study aimed to characterize alterations caused by long-term exposure to male testosterone levels. For this purpose, the Fallopian tubes of nine female-to-male transsexuals, who had been undergoing testosterone treatment for 1-3 years, were compared with the tubes of 19 cycling patients. In the ampulla, testosterone treatment resulted in extensive luminal accumulations of secretions and cell debris which caused ciliary clumping and luminal blockage. Additionally, the percentage of ciliated cells in the ampulla was significantly increased. Transsexual patients, who had had sexual intercourse before surgery, showed spermatozoa trapped in mucus. Finally, in the isthmus complete luminal collapse occurred. Our results imply that fertility in women with elevated levels of testosterone is altered by tubal luminal obstruction resulting in impaired gamete transport and survival.

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Section: Introductionmentioning

confidence: 99%

How do elevated levels of testosterone affect the function of the human fallopian tube and fertility?—New insights

Dulohery

Trottmann

Bour

et al. 2019

Molecular Reproduction Devel

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show abstract

“…antoni, 1987;Rastogi and lela, 1994), presumably reg ulates sex steroids in both Leptodactylus. In fact, an drogens in female anurans seem to play a role, as in males, in inducing reproductive behavior, and are a source of estradiol-170 through aromatization (Chieffi and Pierantoni, 1987;Dubowsky and Smalley, 1993). The estradiol-170 increase, related to ovarian devel opment and growth, seems to be involved in inducing liver vitellogenin synthesis.…”

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confidence: 99%

Changes in Plasma Sex Steroids in Females of Two Sympatric Leptodactylus from Subtropical South America

Mosconi¹,

Cei²,

Ibañez³

et al. 1996

Journal of Herpetology

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Effect of steroid hormones on Bufo arenarum oviduct. Ultrastructural study

et al. 2007

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The endocrine regulation of the mucosa of the oviductal pars convoluta was analyzed by ultrastructural studies demonstrating that ovariectomy, together with a decrease in ovarian steroids circulating levels, caused a marked regression in this portion of Bufo arenarum oviduct. Twenty-five days after ovariectomy, a decrease in the depth of the epithelial and glandular layers was observed due to the notable loss of secretory cells, whose number was clearly smaller than in nonovariectomized females. The remaining secretory cells showed involution signs, with few secretory granules in their cytoplasm, little endoplasmic reticulum near poorly developed Golgi complexes and a large amount of lipid droplets. Cells in an advanced autolysis state were found in the lumen. These characteristics evidence a nonfunctional state of the pars convoluta. Treatment with 5alpha-dihydrotestosterone (DHT) completely reversed the ovariectomy effect, inducing pars convoluta growths and restoring the characteristics of epithelial and glandular secretory cells in the whole pars convoluta, with micrographs similar to the control. These same effects were observed after treatment with estradiol-17beta (E2), progesterone (P) o E(2)+P in the glandular layer of the whole pars convoluta, but only in the epithelial layer of the most anterior region of this duct. In the secretory cells of other segments these treatments induced the formation of granules of high electron density and homogeneous aspect. Each steroid had a particular effect on the pars convoluta. Although E2 and DHT induced the development of the organoids involved in the proteins biosynthesis, P and DHT acted as secretagogues.

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Testosterone Induced Growth of the Oviduct in the Frog, Rana pipiens: Evidence for Local Aromatization

Cited by 16 publications

References 0 publications

How do elevated levels of testosterone affect the function of the human fallopian tube and fertility?—New insights

How do elevated levels of testosterone affect the function of the human fallopian tube and fertility?—New insights

Changes in Plasma Sex Steroids in Females of Two Sympatric Leptodactylus from Subtropical South America

Effect of steroid hormones on Bufo arenarum oviduct. Ultrastructural study

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