Testosterone for peri and postmenopausal women

Somboonporn, Woraluk; Bell, Robin J.; Davis, Susan R.

doi:10.1002/14651858.cd004509.pub2

Cited by 134 publications

(103 citation statements)

References 85 publications

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“…50 The long-term safety data on testosterone supplementation are limited, particularly in regard to cardiovascular risks, with most studies having a relatively short duration of follow-up 70 ; however, it is known to be associated with a reduction in high-density lipoprotein cholesterol. 71 There are few data concerning the effect of testosterone on breast cancer risk. 72 Potential adverse effects include increased hair growth, acne, alopecia, and irreversible deepening of the voice.…”

Section: Menopausal Hormone Therapymentioning

confidence: 99%

“…72 Potential adverse effects include increased hair growth, acne, alopecia, and irreversible deepening of the voice. 71,73 Some authors have advised against prescribing testosterone for female sexual dysfunction (with the exception of HSDD) because of limited data supporting symptomatic benefit and no long-term studies of risk. 73 …”

Section: Menopausal Hormone Therapymentioning

confidence: 99%

See 1 more Smart Citation

Review Article: Sexuality and Risk-Reducing Salpingo-oophorectomy

Tucker

Cohen

2017

Int J Gynecol Cancer

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Section: Menopausal Hormone Therapymentioning

confidence: 99%

Section: Menopausal Hormone Therapymentioning

confidence: 99%

Review Article: Sexuality and Risk-Reducing Salpingo-oophorectomy

Tucker

Cohen

2017

Int J Gynecol Cancer

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“…Attempts to ameliorate losses in oestrogen through hormone replacement therapy (HRT) have, however, courted significant controversy relating both to increased risks of malignancy and vascular events, thereby standing as an exemplar for the difficulty in managing hormone balance during ageing [10,11]. Recognised changes in female sex steroids are matched by the andropause, a relatively poorly defined process characterised by a progressive age-dependent loss of the anabolic androgen testosterone within males [12].…”

Section: The Hypothalamic-pituitary-gonadal Axismentioning

confidence: 99%

The Endocrinology of Ageing: A Mini-Review

Jones

Boelaert

2014

Gerontology

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Significant advances in health and social wellbeing have led to linear gains in life expectancy and an accompanying increase in the burden imposed by age-related morbidities. Complex alterations in hormonal networks which regulate homeostasis and survival may underlie this poor adaptation to later life, as exemplified by an increased fracture risk amongst post-menopausal women. Beyond overt under- or overactivity of hormonal axes, changes in the concentrations of regulatory hormones may also impact on health and disease. Subclinical hyperthyroidism, a disorder characterised by normal thyroxine levels in the presence of decreased thyroid-stimulating hormone, is, for instance, independently associated with an increased risk of atrial fibrillation amongst elderly populations. Both the menopause and subclinical thyroid disease demonstrate the difficulty in reversing endocrine changes in later life, with minimal impact from thyroxine therapy in subclinical hypothyroidism and multiple reports of harm resulting from hormone replacement therapy in peri- and post-menopausal women. Given these findings, strategies to locally regulate hormone bioavailability by altering pre-receptor metabolism may offer greater therapeutic potential in the fight against age-related disease. This review aims to provide an overview of the ageing endocrine system and its potential impact on health and disease in the elderly. It will postulate that strategies to coordinate pre-receptor hormone metabolism and a greater understanding of putative hormonal longevity pathways may offer key new drug targets in the fight against ageing, and will argue against applying the conventional endocrine maxim of ‘block and replace' to hormonal changes seen during ageing.

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“…Meta-analyses have suggested that testosterone therapy may cause dyslipidaemias, such as a reduction in high-density lipoprotein cholesterol and an increase in low-density lipoprotein cholesterol 15,24. However, in the long-term follow-up study there was no significant increase in haematocrit or adverse changes in glycaemic markers or lipid profile 19…”

Section: Testosterone and Its Role In Sexual Functionmentioning

confidence: 99%

Testosterone therapy for menopausal women

2017

DTB

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It has been suggested that there is a link between low circulating concentrations of testosterone and reduced sexual functioning in postmenopausal women, and it has been more than 60 years since the effects of testosterone therapy for the management of menopausal symptoms were first reported. Since then, testosterone supplementation has received growing attention for its potential role in maintaining sexual function in menopausal women. The National Institute for Health and Care Excellence guideline on the diagnosis and management of menopause recommends considering testosterone supplementation for women with low sexual desire if hormone replacement therapy (HRT) alone has been ineffective. However, in the UK no testosterone products are licensed for such use. A testosterone patch authorised by the European Medicines Agency in 2006 for use in women with surgical menopause was withdrawn from the market in 2012 for commercial reasons. Here, we provide an update on the evidence of the effectiveness and safety of testosterone supplementation in menopausal women.

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Testosterone for peri and postmenopausal women

Cited by 134 publications

References 85 publications

Review Article: Sexuality and Risk-Reducing Salpingo-oophorectomy

Review Article: Sexuality and Risk-Reducing Salpingo-oophorectomy

The Endocrinology of Ageing: A Mini-Review

Testosterone therapy for menopausal women

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