Testosterone for peri and postmenopausal women

Abstract

: Only a limited number of studies could be pooled in the meta-analyses. This limited the power of the meta-analysis to provide conclusions about efficacy and safety. However, there is evidence that adding testosterone to HT has a beneficial effect on sexual function in postmenopausal women. There was a reduction in HDL cholesterol associated with the addition of testosterone to the HT regimens. The meta-analysis combined studies using different testosterone regimens. It is, therefore, difficult to estimate the effect of testosterone on sexual function in association with any individual hormone treatment regimen.

A systematic review of randomized controlled trials investigating the efficacy and safety of testosterone therapy for female sexual dysfunction in postmenopausal women

“…Collectively, these multiple randomized placebo‐controlled studies suggest that testosterone therapy significantly improves symptoms of sexual dysfunction in women with natural or surgical menopause. These conclusions are in keeping with two recent systematic reviews of the literature . However, it is important to consider that symptoms of sexual dysfunction do not have a clear relationship with low level of circulating testosterone.…”

A systematic review of randomized controlled trials investigating the efficacy and safety of testosterone therapy for female sexual dysfunction in postmenopausal women

“…Collectively, these multiple randomized placebo‐controlled studies suggest that testosterone therapy significantly improves symptoms of sexual dysfunction in women with natural or surgical menopause. These conclusions are in keeping with two recent systematic reviews of the literature . However, it is important to consider that symptoms of sexual dysfunction do not have a clear relationship with low level of circulating testosterone.…”

Testosterone-induced increase in libido in a patient with a loss-of-function mutation in the AR gene

“…Combined, these results suggest the involvement of central aromatization of testosterone to estradiol in libido. In addition, placebo-controlled and meta-analysis studies confirmed the beneficial effect of testosterone on sexual desire and function in females (19,20,21). Further studies evaluating the response to testosterone therapy in the presence of an aromatase inhibitor will help clarify the direct effect of testosterone and/or its aromatization to estradiol in stimulating sexual desire in females.…”

Testosterone Therapy for Postmenopausal Women: Efficacy and Safety

“…HT, hormone therapy; T, testosterone. (From Somboonporn et al 47 ) difference between treatments was significant for lean body mass (p < 0.05) and percentage of fat tissue (p < 0.05), but not for fat tissue (p < 0.05). 39 Although the two studies cited were of good quality and the results were consistent, the limited number of participants limits the validity of population-wide generalizations.…”

A systematic review of randomized controlled trials investigating the efficacy and safety of testosterone therapy for female sexual dysfunction in postmenopausal women

“…Collectively, these multiple randomized placebo‐controlled studies suggest that testosterone therapy significantly improves symptoms of sexual dysfunction in women with natural or surgical menopause. These conclusions are in keeping with two recent systematic reviews of the literature . However, it is important to consider that symptoms of sexual dysfunction do not have a clear relationship with low level of circulating testosterone.…”

Testosterone-induced increase in libido in a patient with a loss-of-function mutation in the AR gene

“…Combined, these results suggest the involvement of central aromatization of testosterone to estradiol in libido. In addition, placebo-controlled and meta-analysis studies confirmed the beneficial effect of testosterone on sexual desire and function in females (19,20,21). Further studies evaluating the response to testosterone therapy in the presence of an aromatase inhibitor will help clarify the direct effect of testosterone and/or its aromatization to estradiol in stimulating sexual desire in females.…”

Testosterone Therapy for Postmenopausal Women: Efficacy and Safety

“…HT, hormone therapy; T, testosterone. (From Somboonporn et al 47 ) difference between treatments was significant for lean body mass (p < 0.05) and percentage of fat tissue (p < 0.05), but not for fat tissue (p < 0.05). 39 Although the two studies cited were of good quality and the results were consistent, the limited number of participants limits the validity of population-wide generalizations.…”

A systematic review of randomized controlled trials investigating the efficacy and safety of testosterone therapy for female sexual dysfunction in postmenopausal women

“…Collectively, these multiple randomized placebo‐controlled studies suggest that testosterone therapy significantly improves symptoms of sexual dysfunction in women with natural or surgical menopause. These conclusions are in keeping with two recent systematic reviews of the literature . However, it is important to consider that symptoms of sexual dysfunction do not have a clear relationship with low level of circulating testosterone.…”

Testosterone-induced increase in libido in a patient with a loss-of-function mutation in the AR gene

“…Combined, these results suggest the involvement of central aromatization of testosterone to estradiol in libido. In addition, placebo-controlled and meta-analysis studies confirmed the beneficial effect of testosterone on sexual desire and function in females (19,20,21). Further studies evaluating the response to testosterone therapy in the presence of an aromatase inhibitor will help clarify the direct effect of testosterone and/or its aromatization to estradiol in stimulating sexual desire in females.…”

Testosterone Therapy for Postmenopausal Women: Efficacy and Safety

“…HT, hormone therapy; T, testosterone. (From Somboonporn et al 47 ) difference between treatments was significant for lean body mass (p < 0.05) and percentage of fat tissue (p < 0.05), but not for fat tissue (p < 0.05). 39 Although the two studies cited were of good quality and the results were consistent, the limited number of participants limits the validity of population-wide generalizations.…”