Testosterone for Low Libido in Postmenopausal Women Not Taking Estrogen

Davis, Susan Ruth; Moreau, M.; Kroll, Robin; Bouchard, Céline; Panay, Nick; Gass, Margery; Braunstein, Glenn D.; Hirschberg, Angelica Lindén; Rodenberg, Cynthia; Pack, Simon; Koch, Helga; Moufarege, Alain; Studd, John

doi:10.1056/nejmoa0707302

Cited by 409 publications

(289 citation statements)

References 39 publications

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“…Without estrogen/progesterone replacement therapy Davis et al 140 Natural/surgical T Transdermal (patch) 150/300 mg per day 52 weeksAbbreviations: CRP, C-reactive protein; HDL-C, high-density lipoprotein-cholesterol; MT, methyltestosterone, T, testosterone; TU, testosterone undecanoate; m, positive association; k, negative association.…”

Section: Discussionmentioning

confidence: 99%

“…Studies monitoring the effects of testosterone therapy only provide a better model for studying these effects. Only recently, the effect of testosterone only was investigated in a 52-week double-blind placebo-controlled trial 140 in which postmenopausal women received a patch delivering 150 or 300 mg of testosterone per day or placebo. In this study, circulating levels of TT, FT and BT showed a dose-related increase with testosterone treatment, but no difference in lipid profile and glucose metabolism was observed between women treated with testosterone compared with placebo.…”

Section: Postmenopausal Testosterone Therapymentioning

confidence: 99%

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Testosterone, SHBG and cardiovascular health in postmenopausal women

Brand

Schouw

2010

Int J Impot Res

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Cardiovascular disease (CVD) affects men and women differently with women having a lower incidence and later onset of disease. Research has recently refocused interest on the cardiovascular role of androgens. The purpose of this review is to summarize the evidence available on the association between testosterone and cardiovascular health in postmenopausal women. Published studies relating testosterone and sex hormone-binding globulin (SHBG) to CVD and its risk factors were reviewed. Studies included in this review suggest that increased androgenicity, characterized by high testosterone and low SHBG levels, is associated with an adverse CVD risk factor profile in postmenopausal women. However, evidence for an association with cardiovascular events is lacking and it is uncertain whether the observed associations with endogenous testosterone have clinical implications regarding the use of postmenopausal testosterone therapy. Large-scale, longitudinal studies relating testosterone and SHBG levels to cardiovascular risk factors and endpoints are needed to determine the temporal relationship between androgenicity and cardiovascular risk and to ascertain the long-term efficacy and safety of testosterone therapy in postmenopausal women.

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Section: Discussionmentioning

confidence: 99%

Section: Postmenopausal Testosterone Therapymentioning

confidence: 99%

Testosterone, SHBG and cardiovascular health in postmenopausal women

Brand

Schouw

2010

Int J Impot Res

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“…The current recommendation for testosterone treatment is that therapy should be restricted to short-term therapy until long-term safety issues have been resolved. The number of adverse events associated with testosterone replacement treatment in women has been limited when protocols of treatment are optimized to achieve physiologic levels of circulating testosterone (67).…”

Section: Supplementation Of Testosterone and Dhea-s In Womenmentioning

confidence: 99%

Androgen in postmenopausal women

et al. 2012

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Dynamic changes in circulating estradiol level, including increase at menarche and decrease at menopause, occur in a woman's lifetime. Circulating estradiol levels decrease drastically during the menopausal transition, though the levels differ among races. It has been reported that estradiol levels in both Japanese and Chinese women were lower than those in Caucasians, Hispanic and AfricanAmericans (1).Based on data obtained in a previous study (2), we re-analyzed data for 169 healthy men and 252 healthy women aged from 40 to 85 years in the population-based study with addition of data for premenopausal women. Change in circulating estradiol in women from the menopausal transition to postmenopause is characterized as follows : high estradiol level in premenopausal women is drastically decreased and estradiol level in postmenopausal women is significantly lower than that in agematched men. Mean estradiol levels were shown to be 20.1 pg/ml in men and 6.1 pg/ml in postmenopausal women (Figure 1). This dynamic decrease in REVIEW Androgen in postmenopausal women

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“…Hormones affect the brain by binding to specific receptors, and previous work suggests that differences in the organization of brain areas in males and females depend on hormones (14-16). Hormones may affect cognition, mood, well-being, sexuality, and social behavior (16)(17)(18)(19).However, the existing evidence on the relationship between sex hormones and economic behavior is merely correlative. It does not admit causal inference.…”

mentioning

confidence: 99%

A randomized trial of the effect of estrogen and testosterone on economic behavior

Zethraeus

Kocoska-Maras²,

Ellingsen³

et al. 2009

Proc. Natl. Acad. Sci. U.S.A.

175

145

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Existing correlative evidence suggests that sex hormones may affect economic behavior such as risk taking and reciprocal fairness. To test this hypothesis we conducted a double-blind randomized study. Two-hundred healthy postmenopausal women aged 50 -65 years were randomly allocated to 4 weeks of treatment with estrogen, testosterone, or placebo. At the end of the treatment period, the subjects participated in a series of economic experiments that measure altruism, reciprocal fairness, trust, trustworthiness, and risk attitudes. There was no significant effect of estrogen or testosterone on any of the studied behaviors.sex hormones ͉ trust game ͉ ultimatum game ͉ risk aversion H umans display sizeable individual variation in economic behaviors. Heterogeneity is large both in the domain of personal decision making and in the domain of social interaction. Some individuals willingly take risks that others pay to avoid (1), and in situations where some individuals are altruistic and trusting, others are selfish and distrustful (2).Relatively little is known about the sources of such preference heterogeneity, but two recent findings suggest that biological factors are important. First, comparisons of the behavior of identical and fraternal twins indicate that genetics explains a sizeable part of the variation in preferences across a wide range of economic domains (3-5). Second, a controlled increase in the level of the mammalian hormone oxytocin causes more trusting behavior (6).Several studies also report that behavior is correlated with the level of sex hormones. Burnham (7) finds that subjects with a higher testosterone level are more likely to reject unfair offers in the ultimatum game, and Apicella et al. (8) find a correlation between testosterone levels and financial risk-taking behavior. Two studies report that risk-taking behavior varies over the menstrual cycle; women are more risk averse during the ovulatory phase-that is, when the estrogen level is high (9, 10). Because hormone levels in general are under strong genetic influences (11,12), these relationships between hormone levels and behavior suggest one possible channel for the intergenerational transmission of behavior.Because men and women have sharply different levels of sex hormones, it is natural to think that hormones are implied in the differences between male and female behavior. Experimental evidence shows that, on average, women tend to be more risk averse, less competitive, and more prosocial than men (13). Hormones affect the brain by binding to specific receptors, and previous work suggests that differences in the organization of brain areas in males and females depend on hormones (14-16). Hormones may affect cognition, mood, well-being, sexuality, and social behavior (16)(17)(18)(19).However, the existing evidence on the relationship between sex hormones and economic behavior is merely correlative. It does not admit causal inference. To investigate whether there is a causal link, we conducted a double-blind randomized trial, with subjects...

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Testosterone for Low Libido in Postmenopausal Women Not Taking Estrogen

Cited by 409 publications

References 39 publications

Testosterone, SHBG and cardiovascular health in postmenopausal women

Testosterone, SHBG and cardiovascular health in postmenopausal women

Androgen in postmenopausal women

A randomized trial of the effect of estrogen and testosterone on economic behavior

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