Testosterone disruptor effect and gut microbiome perturbation in mice: Early life exposure to doxycycline

Hou, Xiang; Zhu, Lei; Zhang, Xianwei; Zhang, Lili; Bao, Hongduo; Tang, Min-Min; Wei, Ruicheng; Wang, Ran

doi:10.1016/j.chemosphere.2019.01.101

Cited by 28 publications

(13 citation statements)

References 57 publications

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“…22 An animal study showed that antibiotic exposure inhibited mitochondrial dysfunction in a mouse Leydig tumor cell line (MLTC-1), inducing reduced steroidogenesis. 23 Mice exposed to doxycycline subchronically showed a reduction in microbiome diversity and changes in composition. 23 In males, testosterone shows an inhibitory effect on T-cell proliferation.…”

Section: Androgen and Microbiotamentioning

confidence: 99%

“…23 Mice exposed to doxycycline subchronically showed a reduction in microbiome diversity and changes in composition. 23 In males, testosterone shows an inhibitory effect on T-cell proliferation. In contrast to estradiol, testosterone does not alter the intestinal barrier.…”

Section: Androgen and Microbiotamentioning

confidence: 99%

“… 23 Mice exposed to doxycycline subchronically showed a reduction in microbiome diversity and changes in composition. 23 …”

Section: Androgen and Microbiotamentioning

confidence: 99%

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Roles of Sex Hormones and Gender in the Gut Microbiota

Yoon

Kim

2021

J Neurogastroenterol Motil

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Section: Androgen and Microbiotamentioning

confidence: 99%

Section: Androgen and Microbiotamentioning

confidence: 99%

See 1 more Smart Citation

Roles of Sex Hormones and Gender in the Gut Microbiota

Yoon

Kim

2021

J Neurogastroenterol Motil

131

103

View full text Add to dashboard Cite

show abstract

“…Scientific data highlighted how gut microbiota is able to communicate with host distal organs, such as the testis, determining the existence of a gut-microbiota-testis axis [76]. Although the specific mechanisms which regulate this axis have not yet been determined, it was suggest in vivo and in vitro that some endocrine disruptors compounds [77] leads to a reduction of various endocrine and steroidogenic parameters, such as serum testosterone, LH hormone, steroidogenic acute regulatory protein (StAR) expression and alter of the gut male microbiota characteristics [78]. However, more studies are needed to adequately address the matter of how endogenous hormonal influences might regulate microbiota in the male.…”

Section: Role Of Hormone On Male Genital Tracts Microbiotamentioning

confidence: 99%

Human genital tracts microbiota: dysbiosis crucial for infertility

Venneri

Franceschini

Sciarra

et al. 2022

J Endocrinol Invest

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Human body is colonized by trillions of microbes, influenced by several factors, both endogenous, as hormones and circadian regulation, and exogenous as, life-style habits and nutrition. The alteration of such factors can lead to microbial dysbiosis, a phenomenon which, in turn, represents a risk factor in many different pathologies including cancer, diabetes, autoimmune and cardiovascular disease, and infertility. Female microbiota dysbiosis (vaginal, endometrial, placental) and male microbiota dysbiosis (seminal fluid) can influence the fertility, determining a detrimental impact on various conditions, as pre-term birth, neonatal illnesses, and macroscopic sperm parameters impairments. Furthermore, unprotected sexual intercourse creates a bacterial exchange between partners, and, in addition, each partner can influence the microbiota composition of partner’s reproductive tracts. This comprehensive overview of the effects of bacterial dysbiosis in both sexes and how partners might influence each other will allow for better personalization of infertility management.

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“…Postnatal doxycycline exposure of mice disrupted Leydig cells mitochondrial function and decreased quality of sperm as well as caused gut microbiota differences, studied at adult age [26].…”

Section: Facts Animal Experimentsmentioning

confidence: 99%

Dangerous faulty perinatal imprinting by medication: Review and hypothesis

Csaba¹

2019

Clin Obstet Gynecol Reprod Med

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Likewise to the perinatal exposure of endocrine disruptors, some drugs (e.g. painkillers, antibiotics, lipid-soluble vitamins, medicinally used marihuana, vaccine preservative thimerosal, digoxin) are causing faulty imprinting perinatally which could provoke late manifested alterations or diseases. In contrast to the similar perinatal faulty hormonal imprinting, the mechanism of the effect is unknown. The molecules (drugs) which are useful in the perinatal acute situation are originators of late (adult) diseases, which require further medical interventions. These drugs are functional teratogens, and only a selection of a mass of medicaments, which have not been studied from this aspect. As the fetus and infant in the perinatal period are rather sensitive to epigenetically active molecules, it seems important to attend the late sequels of this type of perinatal interventions as well, as oxytocin. Especially important the avoidance and monitoring of lipid-soluble vitamins, which are bound -regardless of their structure-by hormone receptors. The human observations point to the possibility of similar effects by perinatal exposures of any chemical interventions with similar consequences. There is also a possibility of inclination -by imprinting-to diseases, activated by certain effects in adult age. As windows for developmental imprinting are open at puberty, some similar phenomena can be observed also at this period.

show abstract

Testosterone disruptor effect and gut microbiome perturbation in mice: Early life exposure to doxycycline

Cited by 28 publications

References 57 publications

Roles of Sex Hormones and Gender in the Gut Microbiota

Roles of Sex Hormones and Gender in the Gut Microbiota

Human genital tracts microbiota: dysbiosis crucial for infertility

Dangerous faulty perinatal imprinting by medication: Review and hypothesis

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