Testosterone deficiency and the aging male

Gryzinski, Gustavo M.; Bernie, H.L.

doi:10.1038/s41443-022-00555-7

Cited by 3 publications

(2 citation statements)

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“…Concomitant cardiovascular, such as arterial hypertension and endothelial dysfunction, respiratory, mainly OSAS, and metabolic complications, including abnormalities in glucose and lipid profile leading to insulin resistance, diabetes mellitus and dyslipidemia, may further compromise erectile function and induce a decrease of desire and arousability in acromegaly (21,58,60). On the other hand, testosterone decline is known to occur physiologically in ageing men leading to the so-called late-onset (i.e., functional) hypogonadism (63)(64)(65)(66)(67)(68)(69), and to act either as a cause or consequence of some chronic comorbidities, such as metabolic syndrome, diabetes mellitus, hypertension, and cardiovascular disease, commonly seen also in patients with acromegaly (63,68,70). In the current study, elderly patients reported lower IIEF total and sudomain scores, and the prevalence of erectile dysfunction was higher in patients >64 years as compared to younger patients.…”

Section: Discussionmentioning

confidence: 99%

Global psychological assessment with the evaluation of life and sleep quality and sexual and cognitive function in a large number of patients with acromegaly: a cross-sectional study

Pivonello

Auriemma

Veneri

et al. 2022

European Journal of Endocrinology

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Objective: Acromegaly is associated with somatic disfigurements which impair self-perception of well-being and quality of life. Nowadays limited data are available on the interplay between hormonal excess and psychological discomfort. The study aimed at investigating the psychological profile, sleep quality, sexual function, cognitive functions, and quality of life in acromegaly. Methods: in 223 acromegaly patients from five referral centres global psychological profile, sleep quality, sexual function, cognitive function, and quality of life were investigated. Results: depression was found in 30% of patients, and anxiety in two-thirds, together with severe discomfort in body image mainly in women. Obstructive sleep apnea syndrome (OSAS)risk and sleep disorders were found in >50% of patients, and daily sleepiness in 20%. Sexual dysfunction was reported in most patients, with the most severe impairment in women. Cognitive functions were compromised in 10% of cases. Disease duration, patient age and gender were the main determinants of such psychological effects. Depression (p=0.047), somatic affective mood lowering (p=0.021), state (p<0.001) and trait (p=0.013) anxiety, and body image distortion at Body Uneasiness Test (BUT) A (p<0.001) and B (p=0.006) were significantly worsened in patients <45 years, and slightly worsen in those diagnosed <2 years before. International Index for Erectile Function (IIEF)-15 (p<0.001) and Female Sexual Function Index (FSFI) (p<0.001) scores were significantly worsened in patients >64 years and slightly worsened in those diagnosed >10 years before, particularly in presence of cardiometabolic and respiratory complications. Cognitive symptoms were slightly worsened in older patients and in those with long disease. Conclusions: Acromegaly is associated with a relevant impairment of psychological profile persisting despite remission and long-term medical treatment.

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Section: Discussionmentioning

confidence: 99%

Global psychological assessment with the evaluation of life and sleep quality and sexual and cognitive function in a large number of patients with acromegaly: a cross-sectional study

Pivonello

Auriemma

Veneri

et al. 2022

European Journal of Endocrinology

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“…Around 30% of men between the ages of 40 and 79 are affected by TD [ 2 ]. Besides aging, factors like obesity, dyslipidemia, metabolic syndrome, hypertension, diabetes mellitus, and chronic kidney disease have been linked to decreased TT levels and an elevated risk of developing TD [ 3 – 6 ]. TD can result in muscle atrophy, reduced strength, compromised cognitive function, poorer sleep quality, an increased risk of depression, and reduced life satisfaction in men [ 7 , 8 ].…”

Section: Introductionmentioning

confidence: 99%

Positive association between serum bilirubin within the physiological range and serum testosterone levels

Ling,

Liu,

Yao

et al. 2024

BMC Endocr Disord

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Backgrounds Research has demonstrated that elevated serum total bilirubin (STB) levels have a beneficial impact on various diseases, particularly metabolic syndrome. This study aims to investigate the association between STB levels and serum testosterone (STT) in order to determine if bilirubin plays a protective role in relation to testosterone deficiency (TD) risk. Methods In this study, a total of 6,526 eligible male participants aged 20 years or older were analyzed, all of whom took part in the National Health and Nutrition Examination Survey (NHANES) conducted between 2011 and 2016. To investigate the relationship between STB and STT levels, we employed weighted multivariate regression models along with restricted cubic splines (RCS). Additionally, a subgroup analysis was conducted to explore the heterogeneity of this relationship across different subpopulations. Results Among the participants, 1,832 individuals (28.07%) were identified as having testosterone deficiency (TD), defined as an STT level below 300 ng/dL. A significant positive correlation between STB and STT levels was observed in both crude and adjusted models (all P < 0.0001). The association between STB and STT levels was found to be statistically significant up to a threshold of 17.1 µmol/L, after which it became statistically insignificant(P for non-linearity = 0.0035). Weighted logistic regression analysis indicated that a 1 µmol/L increase in STB was associated with a 4% decrease in the likelihood of TD (odds ratio = 0.96, P < 0.0001). Subgroup analysis showed that the inverse relationship was limited to individuals aged 60 and over, non-smokers/drinkers, and obese individuals. Conclusion STB within the physiological range(17.1 µmol/L) was positively associated with STT in adult males. The potential protective role of bilirubin regarding testosterone levels merits further exploration.

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