Testosterone Attenuates Age-Related Fall in Aerobic Function in Mobility Limited Older Men With Low Testosterone

Storer, Thomas W.; Bhasin, Shalender; Travison, Thomas G.; Pencina, Karol M.; Miciek, Renee; McKinnon, Jennifer; Basaria, Shehzad

doi:10.1210/jc.2015-4333

Cited by 29 publications

(19 citation statements)

References 40 publications

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“…The present results reinforce the idea that SHBG 3 and TESTO (Storer et al 2016) are weakly correlated with baseline fitness. In the CARDIA Male Hormone Study (391 blacks and 604 whites, aged 24-32 years), SHBG was significantly (p = 0.05) associated with estimated CRF among white men, with quartiles four and two having the highest (33.5 nmol/L) and lowest (27.8 nmol/L) SHBG concentrations, respectively (Wolin et al 2007).…”

Section: Discussionsupporting

confidence: 89%

“…In the CARDIA Male Hormone Study (391 blacks and 604 whites, aged 24-32 years), SHBG was significantly (p = 0.05) associated with estimated CRF among white men, with quartiles four and two having the highest (33.5 nmol/L) and lowest (27.8 nmol/L) SHBG concentrations, respectively (Wolin et al 2007). TESTO supplementation in mobility-limited older men (n = 64) increased hemoglobin and attenuated the age-related declines in VO 2 peak (Storer et al 2016). However, our results also contradict those of other reports.…”

Section: Discussionmentioning

confidence: 96%

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Plasma Steroids and Cardiorespiratory Fitness Response to Regular Exercise

Rankinen

Leon

et al. 2017

Research and Perspectives in Endocrine Interactions

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The aim of this report is to evaluate the relationships between baseline levels of adrenal, gonadal and conjugated steroids and baseline cardiorespiratory fitness, as assessed by maximal oxygen uptake (VO 2 max), as well as its response to a standardized exercise program. To address this aim we used a subset of the HERITAGE Family Study (N = 448). In men, significant positive associations were found between baseline VO 2 max/kg weight and plasma levels of androsterone glucuronide (ADTG), dihydrotesterone (DHT), 17 hydroxy progesterone (OHPROG), sex hormone binding globulin (SHBG), and testosterone (TESTO), and negative association with aldosterone (ALDO). In women, only the free androgen index (FAI) was negatively associated with baseline VO 2 max/kg weight. Neither baseline plasma steroid levels nor SHBG concentrations were associated with the gains in VO 2 max resulting from exposure to the 20-week aerobic exercise program after adjustment for baseline values, age and ethnicity (white or black). We conclude that baseline plasma steroid levels are only weakly associated with individual differences in cardiorespiratory fitness in the sedentary state in men but not in women, whereas no association could be detected with trainability, as defined by the change in VO 2 max with the exercise program.

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Section: Discussionsupporting

confidence: 89%

Section: Discussionmentioning

confidence: 96%

Plasma Steroids and Cardiorespiratory Fitness Response to Regular Exercise

Rankinen

Leon

et al. 2017

Research and Perspectives in Endocrine Interactions

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show abstract

“…Collectively, testosterone stimulates cellular metabolism and survival pathways, inhibiting the cell death pathway. According to Sinha-Hikim et al [22] and Storer et al [23], outcomes associated with the effect of anabolic steroids on hypertrophy, muscle strength, and functional parameters are dosedependent. Being elderly as responsive to graded doses of exogenous testosterone as young people [24].…”

Section: Discussionmentioning

confidence: 99%

Total training load may explain similar strength gains and muscle hypertrophy seen in aged rats submitted to resistance training and anabolic steroids

et al. 2017

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This study aimed to quantify training parameters and analyze the morphological response of aged muscles submitted to resistance training and anabolic steroids. Aged Wistar rats were divided into groups: C - initial control; CF - final control; CAS - control with anabolic steroid, RT - resistance training, and RTA - resistance training with anabolic steroid. Maximum carried load, absolute and relative loads increased significantly in RT and RTA. RTA demonstrated greater relative load than RT. Average total volume, total climbing volume, relative total volume, relative total climbing volume, and mean climbing volume were similar between groups RT and RTA. For soleus, CAS, RT, and RTA enlarged cross-sectional area of type I fibers and nuclear ratio. As for type II fibers, RTA was higher than C and CF. For plantaris, RT and RTA showed significant increases in myofibers type I compared to C and CF. For type II fibers, RTA showed a significant increase compared to C and CF. Regarding the nuclear ratio, RT and RTA showed a higher ratio than C, CF, and CAS. Our results demonstrated that both RT and RTA were not different among the analyzed morphological parameters. This fact can be explained by the absence of differences found in the training variables analyzed.

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“… 37 Similarly, in a subset analysis of 64 mobility-limited older participants in the Testosterone in Older Men with Mobility Limitation (TOM) Trial, daily application of testosterone gel for 6 months attenuated the age-related decline in aerobic function. 38 …”

Section: Small Mechanistic Studies Showing Potential Cardiovascular Bmentioning

confidence: 99%

Trials of testosterone replacement reporting cardiovascular adverse events

Gagliano‐Jucá

Basaria

2018

Asian J Androl

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The numbers of testosterone prescriptions written have increased several-fold worldwide, but the incidence of pathological hypogonadism due to hypothalamic, pituitary, and testicular disease has remained unchanged. Most of these prescriptions are being dispensed to middle-aged and older men who have experienced age-related decline in serum testosterone levels; a subset of the population in which benefits of testosterone replacement is at best, modest. Recently, some randomized controlled trials have reported increased cardiovascular events in men (mainly older men and those with prevalent cardiovascular disease) with testosterone use, and a few recent meta-analyses have confirmed these findings. In this review, we discuss trials of testosterone therapy that have reported higher cardiovascular events, relevant trials that have not reported increased cardiovascular events and large trials that have focused on cardiovascular risk (mainly atherosclerosis progression) as their main outcome. We also review findings from meta-analyses that have evaluated cardiovascular events in various testosterone trials. Finally, we discuss some potential mechanisms by which testosterone use might result in an increased cardiovascular risk. As none of the trials conducted to date were adequately powered to evaluate cardiovascular events, no firm conclusions can be drawn regarding the cardiovascular safety of testosterone therapy at this time. In the interim, we hope that this review will help practitioners make informed decisions regarding the care of their patients.

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Testosterone Attenuates Age-Related Fall in Aerobic Function in Mobility Limited Older Men With Low Testosterone

Abstract: Testosterone supplementation in mobility-limited older men increased hemoglobin and attenuated the age-related declines in V̇O2peak and V̇O2θ. Long-term intervention studies are needed to determine the durability of this effect.

Cited by 29 publications

References 40 publications

Plasma Steroids and Cardiorespiratory Fitness Response to Regular Exercise

Plasma Steroids and Cardiorespiratory Fitness Response to Regular Exercise

Total training load may explain similar strength gains and muscle hypertrophy seen in aged rats submitted to resistance training and anabolic steroids

Trials of testosterone replacement reporting cardiovascular adverse events

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