Testosterone and Gonadotropins in Infertile Men with Sertoli Cell Only Syndrome from Gaza Strip

Abstract

Abstract Abstract Abstract Aim: Aim: Aim: Aim: Aim: To assess serum testosterone and gonadotropins in Sertoli cell only syndrome patients from Gaza Strip.Methods: Methods: Methods: Methods: Methods: Based on testicular biopsy, a cross section of 74 Sertoli cell only syndrome patients were enrolled in the study. Age matched 44 fertile men were served as controls. Patients and controls were questioned for their medical history. Blood samples were drawn and serum testosterone, luteinizing hormone (LH), and follicle stimulating hormone (FSH) were determined by enzyme-linked immunosorbent assay. Data were computer analyzed using SPSS/PC, version 18.0. Results:Results: Results: Results: Results: Varicocele and hormonal problems were significantly more frequent among patients than controls (P<0.05). Serum testosterone was significantly lower in patients compared to controls (1.7±1.3 versus 5.0±2.2 ng/ml, P=0.000). In contrast, LH and FSH were significantly higher in patients than controls (12.8±9.7 and 20.8±14.8 mlU/ml versus 6.3±3.1 and 7.7±3.9 mlU/ml, P=0.000, respectively). Hypergonadotrophic hypogonadism and hypogonadotrophic hypogonadism patients showed lower levels of testosterone compared to the normal reference value (0.9±0.5 and 0.5±0.4 ng/ml versus 2.0-7.0 ng/ml). Higher levels of LH and FSH were recorded in hypergonadotrophic hypogonadism (24.5±2.6 and 37.4±6.7 mlU/ml) compared to the reference values of 2.0-13.0 and 2.5-10.0 mlU/ml, respectively whereas LH and FSH levels were lower in hypogonadotrophic hypogonadism (0.6±0.4 and 0.6±0.5 mlU/ml, respectively). In this context, all hypergonadotrophic hypogonadism and hypogonadotrophic hypogonadism patients showed abnormal levels of testosterone, LH and FSH. Conclusions:Conclusions: Conclusions: Conclusions: Conclusions: Abnormal levels of serum testosterone, LH and FSH, particularly in hypergonadotrophic hypogonadism and hypogonadotrophic hypogonadism were identified in infertile men with Sertoli cell only syndrome from Gaza Strip. K K K K Ke e e e eyw yw yw yw ywor or or

Glucose and lipid profiles in men with non-obstructive azoospermia

“…In this study, patients with SCO had the lowest testosterone and highest FSH concentrations. This was in accordance with a previous study by Yassin et al [27],…”

“…In this study, patients with SCO had the lowest testosterone and highest FSH concentrations. This was in accordance with a previous study by Yassin et al [27], wherein lower testosterone (1.7 ± 1.3 vs. 5.0 ± 2.2 ng/mL; P <0.001) and higher FSH (20.8 ± 14.8 vs 7.7 ± 3.9 mIU/mL; P <0.001) concentrations were found in patients with SCO syndrome (SCOS) than in fertile men. Another study of 134 patients with SCOS also revealed low testosterone (4.4 ± 1.6 ng/mL) and high FSH (18.9 ± 9.0 mIU/mL) concentrations [28].…”

Alterations in DNA methylation patterns and gene expression in spermatozoa of subfertile males

“…Infertility is a complex problem and associated with several factors such as hormonal, biological, genetic and lifestyle factors (Krausz & Chianese, 2014;Yassin, Lubbad, Taha, Laqqan, & Jamiea, 2017). About 15% of couples worldwide suffer from infertility problem (Inhorn & Patrizio, 2015), in addition, male infertility problems considered as a major cause of infertility in human couples (Anawalt, 2013).…”

Aberrations in sperm DNA methylation patterns of males suffering from reduced fecundity

“…Infertility has been generally defined as an inability to achieve pregnancy after 12 months of regular unprotected intercourse (Poongothai, Gopenath, & Manonayaki, ), and infertility is a complex disorder that may be a result of genetic, hormonal and environmental factors (Anawalt, ; Barazani, Katz, Nagler, & Stember, ; Ferlin & Foresta, ; Yassin, Lubbad, Taha, Laqqan, & Jamiea, ). Semen analysis is routine analysis, that is used to evaluate the male partner of the infertile couple (Boivin, Bunting, Collins, & Nygren, ; Tadeu Andrade‐Rocha, ) and 15% of couples around worldwide suffered from infertility problems (Kumar & Singh, ; Rives, ).…”