Testosterone and Adult Neurogenesis

Spritzer, Mark D.; Roy, Ethan

doi:10.3390/biom10020225

Cited by 39 publications

(26 citation statements)

References 218 publications

(331 reference statements)

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“…38 The higher terminal body mass observed in males in comparison to females could be due to the greater trophic effects of testosterone and growth hormone in males compared to females. 39,40 An increase in body mass is associated with visceral obesity that is known to result in poor cardio-metabolic health. 41…”

Section: Discussionmentioning

confidence: 99%

Neonatal zingerone protects against the development of high-fructose diet-induced metabolic syndrome in adult Sprague-Dawley rats

Muhammad

Lembede

Erlwanger

2020

J Dev Orig Health Dis

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During the early postnatal period, dietary manipulations can alter the developmental trajectory of the growing offspring, causing beneficial or adverse health outcomes later in adult life. We investigated the potential preventive effects of neonatal zingerone intake on the development of fructose-induced metabolic derangements in rats. Four-day old male and female Sprague-Dawley rat pups (n = 79) were randomly grouped and administered: 10 ml/kg body weight (bwt) of distilled water (W), 10 ml/kg bwt 20% fructose solution (FS), 10 ml/kg bwt fructose solution + 40 mg/kg bwt of zingerone in distilled water (ZF) or 40 mg/kg bwt of zingerone in distilled water (ZW) pre-weaning. After weaning, W and ZW continued on unlimited tap water, while FS and ZF continued on unlimited fructose solution for 10 weeks. Body mass and food and fluid intake were evaluated, plasma was collected for metabolic assays and visceral fat was quantified. Food intake was decreased, fructose and overall caloric intake were increased due to fructose feeding in both sexes (P < 0.05). When compared with the controls, the high-fructose diet significantly raised the terminal body masses of females (P < 0.0001), concentrations of triglycerides, total cholesterol, LDL-c, TG:HDL-c ratio and visceral fat mass relative to bwt in both sexes (P < 0.05). Zingerone prevented (P < 0.05) the fructose-induced increase in body mass (females) and hypercholesterolemia (both sexes). Levels of HDL-c, glycaemic parameters and adiponectin were not affected by the interventions (P > 0.05). Sex-related differences were observed in food, fluid and caloric intake, terminal mass, cholesterol subtypes and visceral fat percentage (P < 0.05). Zingerone could be used strategically in the neonatal phase as a prophylatic management of high-fructose diet-induced metabolic syndrome.

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Section: Discussionmentioning

confidence: 99%

Neonatal zingerone protects against the development of high-fructose diet-induced metabolic syndrome in adult Sprague-Dawley rats

Muhammad

Lembede

Erlwanger

2020

J Dev Orig Health Dis

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“…For this review, we will focus on a subset of steroid hormones synthesized primarily in the adrenal cortex and gonads, namely the stress and sex hormones. Stress hormones such as glucocorticoids, and sex hormones such as estradiol, progesterone, and testosterone, impact neurogenesis and gliogenesis in the CNS, as well as OL survival and remyelination in multiple sclerosis and other myelin-related diseases [ 25 , 31 , 176 , 177 ]. As we will discuss below, steroid hormones influence OL development and myelination in both development and adulthood.…”

Section: Steroid Hormonesmentioning

confidence: 99%

Hormonal Regulation of Oligodendrogenesis I: Effects across the Lifespan

et al. 2021

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The brain’s capacity to respond to changing environments via hormonal signaling is critical to fine-tuned function. An emerging body of literature highlights a role for myelin plasticity as a prominent type of experience-dependent plasticity in the adult brain. Myelin plasticity is driven by oligodendrocytes (OLs) and their precursor cells (OPCs). OPC differentiation regulates the trajectory of myelin production throughout development, and importantly, OPCs maintain the ability to proliferate and generate new OLs throughout adulthood. The process of oligodendrogenesis, the creation of new OLs, can be dramatically influenced during early development and in adulthood by internal and environmental conditions such as hormones. Here, we review the current literature describing hormonal regulation of oligodendrogenesis within physiological conditions, focusing on several classes of hormones: steroid, peptide, and thyroid hormones. We discuss hormonal regulation at each stage of oligodendrogenesis and describe mechanisms of action, where known. Overall, the majority of hormones enhance oligodendrogenesis, increasing OPC differentiation and inducing maturation and myelin production in OLs. The mechanisms underlying these processes vary for each hormone but may ultimately converge upon common signaling pathways, mediated by specific receptors expressed across the OL lineage. However, not all of the mechanisms have been fully elucidated, and here, we note the remaining gaps in the literature, including the complex interactions between hormonal systems and with the immune system. In the companion manuscript in this issue, we discuss the implications of hormonal regulation of oligodendrogenesis for neurological and psychiatric disorders characterized by white matter loss. Ultimately, a better understanding of the fundamental mechanisms of hormonal regulation of oligodendrogenesis across the entire lifespan, especially in vivo, will progress both basic and translational research.

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“…Steroid hormones, including testosterone and aromatization of testosterone to estrogen, is essential in regulating many key neural functions. [105][106][107][108] Reductions in these steroid hormones, especially estrogen, is linked to later neurobehavioral disorders, such as Alzheimer's Disease. 105,106 Biosynthesis of unsaturated fatty acids is another pathway likely reduced in response to increases in Prevotella spp.…”

Section: Discussionmentioning

confidence: 99%

Developmental Exposure to Silver Nanoparticles Leads to Long Term Gut Dysbiosis and Neurobehavioral Alterations

Lyu

Ghoshdastidar

Rekha

et al. 2020

Preprint

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Due to their antimicrobial properties, silver nanoparticles (NPs) are used in a wide range of consumer products that includes topical wound dressings, coatings for biomedical devices, and food-packaging to extend the shelf-life. Despite their beneficial antimicrobial effects, developmental exposure to such NPs may lead to gut dysbiosis and long-term health consequences in exposed offspring. Silver NPs can cross the placenta and blood-brain-barrier to translocate in the brain of offspring. The underlying hypothesis tested in the current study was that developmental exposure of male and female mice to silver NPs disrupts the microbiome-gut-brain axis. To examine for such effects, C57BL6 female mice were exposed orally to silver NPs at a dose of 3 mg/kg BW or vehicle control two weeks prior to breeding and throughout gestation. Male and female offspring were tested in various mazes that measure different behavioral domains, and the gut microbial profiles were surveyed from 30 through 120 days of age. Our study results suggest that developmental exposure results in increased likelihood of engaging in repetitive behaviors and reductions in resident microglial cells. Echo-MRI results indicate increased body fat in offspring exposed to NP exhibit. Coprobacillus spp., Mucispirillum spp., and Bifidobacterium spp. were reduced, while Prevotella spp., Bacillus spp., Planococcaceae, Staphylococcus spp., Enterococcus spp., and Ruminococcus spp. were increased in those developmentally exposed to NPs. These bacterial changes were linked to behavioral and metabolic alterations. In conclusion, developmental exposure of silver NPs results in long term gut dysbiosis, body fat increase and neurobehavioral alterations in offspring.

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Testosterone and Adult Neurogenesis

Cited by 39 publications

References 218 publications

Neonatal zingerone protects against the development of high-fructose diet-induced metabolic syndrome in adult Sprague-Dawley rats

Neonatal zingerone protects against the development of high-fructose diet-induced metabolic syndrome in adult Sprague-Dawley rats

Hormonal Regulation of Oligodendrogenesis I: Effects across the Lifespan

Developmental Exposure to Silver Nanoparticles Leads to Long Term Gut Dysbiosis and Neurobehavioral Alterations

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