Testosterone analysis in prostate cancer patients

Multivariate logistic regression analysis of the clinical factors influencing locally advanced prostate cancer

“…The PCa level is closely related to age ( 22 ), levels of androgens ( 23 ), genetics ( 24 ) and obesity ( 25 ). Increasing evidence suggests obesity to be associated with an increased incidence of aggressive PCa ( 9 , 10 , 26 - 30 ) as well as an increased risk of biochemical failure following radical prostatectomy ( 31 ) and external-beam radiotherapy ( 32 ), Such results may be associated with a higher prevalence of complications following androgen-deprivation therapy, increased PCa-specific mortality, and difficulties in the treatment of obese men.…”

“…Increasing evidence suggests obesity to be associated with an increased incidence of aggressive PCa ( 9 , 10 , 26 - 30 ) as well as an increased risk of biochemical failure following radical prostatectomy ( 31 ) and external-beam radiotherapy ( 32 ), Such results may be associated with a higher prevalence of complications following androgen-deprivation therapy, increased PCa-specific mortality, and difficulties in the treatment of obese men. Obesity may have an impact on the development and progression of PCa by influencing levels of adipokines ( 33 ), testosterone ( 23 ), and systemic inflammation ( 34 ). There is also evidence that PLR as an inflammatory index is a robust prognostic marker in nonmetastatic ccRCC (clear cell renal cell carcinoma) that clearly outperforms other inflammatory indexes in those who had undergone nephrectomy.…”

Integrating Single-Cell RNA-seq to construct a Neutrophil prognostic model for predicting immune responses in non-small cell lung cancer

“…Subsequently, we performed targeted drug screening against genes in the prognostic model. As a small molecule compound that can effectively bind to MS4A7 and increase its expression, Testosterone and Estradiol are steroid hormones, Testosterone reduction prevents androgen signal transduction and counteracts prostate cancer by temporarily reducing tumor growth [44], and Estradiol can act as an immunomodulator to play a role in immune and in ammatory processes [45]. In addition, Abrine and Resorcinol showed outstanding performance in increasing the expression of CXCR2.…”

Current Routine Testosterone Immunoassays Are Unsuitable for Lowering the General Castration Cutoff Recommendation to <0.7 nmol/l (20 ng/dl)

“…Castration-resistant PC is defined as progressive disease while having sufficiently low serum testosterone concentrations that reflect adequate castration. The generally recommended testosterone castration cutoff (TCC) of 1.7 nmol/l (50 ng/dl) to define adequate castration treatment was initially based on the lowest possible detection level of historical testosterone measurement systems and has largely remained unchanged in clinical guidelines [1] , [2] , [3] . Recent investigations have shown that lower testosterone castration levels correlate with better survival.…”

“…Our group recently reported a method comparison of the four most widely used immunoassay-based testosterone measurement systems and one liquid chromatography-tandem mass spectrometry (LC-MS/MS) measurement system in a study using sera from 120 castrated patients with PC [7] . LC-MS/MS technology is considered the reference methodology for steroid and testosterone analysis owing to its superior analytical sensitivity and specificity and accuracy, especially for the lower analytical range (<2.0 nmol/l) [1] , [8] . Correlations between measurement systems were determined.…”