Testis-Specific Genes Deregulation in the Testis of COVID-19 Patients: A Potential Driver of Spermatogenesis Disruption?

Pivonello, Rosario; Angelis, Cristina de; Menafra, Davide; Colao, Annamaria

doi:10.1210/clinem/dgac730

Cited by 1 publication

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References 9 publications

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“…FSH did not reveal a significant difference between the three groups. The polymorphism of the androgen receptor has been studied as another possible cause of a serious COVID-19 infection, as well [27].…”

Section: Discussionmentioning

confidence: 99%

Effects of COVID-19 Infection on Spermatogenesis, Oxidative Stress and Erectile Function

Törzsök,

Oswald,

Steiner

et al. 2023

JCM

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Background: Our aim was to evaluate the effect of COVID-19 infection on male fertility and sexual function. Methods: Thirty-one patients were investigated over a mean follow-up of 90 days (22–527) after a COVID-19 infection. Erectile dysfunction (ED), blood tests for sexual hormones, semen analysis including analysis of oxidative stress (OS), as well as COVID-19 antibody titer and the nasal COVID-19 PCR test were evaluated pre- and post-infection. Results: Five patients reported a mild de novo ED (16.13%). One patient had a de novo positive mixed antiglobulin reaction test after the infection. We found no significant difference between pre-COVID-19 and post-COVID-19 spermiogram parameters (p = 0.815). OS showed no significant association with COVID-19 infection, but with pathological spermiogram categories, sperm concentration, total sperm count, testis volume, FSH and testosterone. Conclusion: COVID-19 infection does not appear to affect sperm quality and OS negatively in the intermediate term. Further investigations will be needed to assess the potential long-term effects of the infection and vaccination on male sexual function and fertility.

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Section: Discussionmentioning

confidence: 99%