Testis-on-chip platform to study ex vivo primate spermatogenesis and endocrine dynamics

Sharma, Swati; Venzac, Bastien; Burgers, Thomas; Schlatt, Stefan; Gac, Séverine Le

doi:10.1016/j.ooc.2022.100023

Cited by 5 publications

(2 citation statements)

References 64 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…22 To date, a variety of human tissue barriers have been emulated, including the BBB, 23 blood–retina barrier, 24,25 pulmonary endothelial barrier, 26–28 and blood–testis barrier. 29,30 These models not only demonstrate similar structures to those in vivo but also possess tissue-barrier specific functions.…”

Section: Introductionmentioning

confidence: 95%

Bioengineering of a human physiologically relevant microfluidic blood–cerebrospinal fluid barrier model

Zhou

Qiao

et al. 2023

Lab Chip

View full text Add to dashboard Cite

show abstract

Section: Introductionmentioning

confidence: 95%

Bioengineering of a human physiologically relevant microfluidic blood–cerebrospinal fluid barrier model

Zhou

Qiao

et al. 2023

Lab Chip

View full text Add to dashboard Cite

show abstract

“…and Young and Huh in 2021, 78 and are expanded recently to the vagina, 79 cervix, 80 and pregnancy‐related models 81 . In contrast, the male reproductive system is less represented in OOC technologies 82 with very few models of prostate gland, 83 epididymis, 84,85 spermatogenesis, 86 and testis 87,88 …”

Section: Engineering Microphysiological Systemsmentioning

confidence: 99%

Organ‐on‐a‐chip technologies for biomedical research and drug development: A focus on the vasculature

2023

View full text Add to dashboard Cite

Current biomedical models fail to replicate the complexity of human biology.Consequently, almost 90% of drug candidates fail during clinical trials after decades of research and billions of investments in drug development. Despite their physiological similarities, animal models often misrepresent human responses, and instead, trigger ethical and societal debates regarding their use. The overall aim across regulatory entities worldwide is to replace, reduce, and refine the use of animal experimentation, a concept known as the Three Rs principle. In response, researchers develop experimental alternatives to improve the biological relevance of in vitro models through interdisciplinary approaches. This article highlights the emerging organ-on-a-chip technologies, also known as microphysiological systems, with a focus on models of the vasculature. The cardiovascular system transports all necessary substances, including drugs, throughout the body while in charge of thermal regulation and communication between other organ systems. In addition, we discuss the benefits, limitations, and challenges in the widespread use of new biomedical models. Coupled with patient-derived induced pluripotent stem cells, organon-a-chip technologies are the future of drug discovery, development, and personalized medicine. K E Y W O R D Sbiomedical, microphysiological systems, models, organ-on-a-chip, vasculatureThis is an open access article under the terms of the Creative Commons Attribution License, which permits use, distribution and reproduction in any medium, provided the original work is properly cited.

show abstract

Global Literature Analysis of Organoid and Organ‐on‐Chip Research

Shoji

Davis

Mummery

et al. 2023

Adv Healthcare Materials

View full text Add to dashboard Cite

Organoids and cells in organ‐on‐chip platforms replicate higher‐level anatomical, physiological, or pathological states of tissues and organs. These technologies are widely regarded by academia, the pharmacological industry and regulators as key biomedical developments. To map advances in this emerging field, a meta‐analysis based on a quality‐controlled text‐mining algorithm is performed. The analysis covers titles, keywords, and abstracts of categorized academic publications in the literature and preprint databases published after 2010. The algorithm identifies and tracks 149 and 107 organs or organ substructures modeled as organoids and organ‐on‐chip, respectively, stem cell sources, as well as 130 diseases, and 16 groups of organisms other than human and mouse in which organoid/organ‐on‐chip technology is applied. The meta‐analysis illustrates changing diversity and focus in organoid/organ‐on‐chip research and captures its geographical distribution. The downloadable dataset provided is a robust framework for researchers to interrogate with their own questions.

show abstract

Testis-on-chip platform to study ex vivo primate spermatogenesis and endocrine dynamics

Cited by 5 publications

References 64 publications

Bioengineering of a human physiologically relevant microfluidic blood–cerebrospinal fluid barrier model

Bioengineering of a human physiologically relevant microfluidic blood–cerebrospinal fluid barrier model

Organ‐on‐a‐chip technologies for biomedical research and drug development: A focus on the vasculature

Global Literature Analysis of Organoid and Organ‐on‐Chip Research

Contact Info

Product

Resources

About