Testing Umbilical Cords for Funisitis due to Treponema pallidum Infection, Bolivia

Guarner, Jeannette; Southwick, K; Greer, Patricia W.; Bartlett, Jeanine; Santander, Ana Fernández; Blanco, S.; Pope, Victoria; Levine, William C.; Zaki, SR

doi:10.3201/eid0605.000507

Cited by 21 publications

(20 citation statements)

References 4 publications

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“…Detection of bacterial antigens using IHC assays has been observed in other bacterial infections such as anthrax, leptospirosis, and syphilis [12,13,17,18]. In some of these infections, particularly if antibiotic therapy has been given, bacterial antigens can be more abundant than intact bacteria, and in some cases, antigens can be the only evidence of the causative infectious agent [17].…”

Section: Discussionmentioning

confidence: 96%

Immunohistochemical evidence of Clostridium sp, Staphylococcus aureus, and group A Streptococcus in severe soft tissue infections related to injection drug use

Guarner¹,

Bartlett²,

Reagan³

et al. 2006

Human Pathology

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Section: Discussionmentioning

confidence: 96%

Immunohistochemical evidence of Clostridium sp, Staphylococcus aureus, and group A Streptococcus in severe soft tissue infections related to injection drug use

Guarner¹,

Bartlett²,

Reagan³

et al. 2006

Human Pathology

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“…The umbilical cord, as a part of fetal tissues, is convenient for collection without endangering the fetus [20]. It can provide direct evidence of fetal exposure to toxins in the mother's body [21,22]. Quantitative and real-time PCR is a highly sensitive, reproducible and fast method for measuring gene expression [23].…”

Section: Discussionmentioning

confidence: 99%

Analyses of levels of thyroid hormones and its receptor expression in puerperants and newborns from an e-waste dismantling site

Cui

et al. 2008

Front. Med. China

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In this study, the serum levels, including thyroid hormones free triiodothyronine (FT 3 ), free thyroxine (FT 4 ),thyroid stimulating hormone(TSH)among the subjects from the exposed group (n 5 48) and the control group (n 5 45) were detected by immuno radiometric assay (IRMA). The expression levels of TRa1, TRb1, TSHR mRNA in placentas and umbilical cords were detected by fluorescent quantitative real-time PCR (FQ-PCR). The correlations between the thyroid hormone levels in maternal serum and umbilical serum, and between the expression levels of its receptors mRNA in placentas and umbilical cords were determined. We found that the FT 4 levels of both maternal serum and umbilical cord serum in the exposed group were lower than those in the control (P , 0.05). However, the increased TSH levels in the exposed group had statistically significance compared to those in the control group (P , 0.05). The TRa1 and TRb1 mRNA levels both in placentas and umbilical cords in the exposed group were lower than those in the control group (P , 0.05 and 0.01). However, the TSHR mRNA levels in the exposed group were significantly different compared to those in the control group (P , 0.01). The serum FT4 and TSH levels of parturient women were positively correlated with those of the newborns in both groups (P , 0.05 and 0.01). The mRNA levels of TRa1, TRb1 and TSHR in the placentas were positively correlated with those in umbilical cords in both groups (P , 0.01). The findings suggest that some environmental pollutants existing in the electronic waste (ewaste) dismantling region may affect the health of local parturient women and newborns, representing changes both in serum levels of thyroid hormones and in mRNA expression of its receptors.

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“…A necrotizing funisitis may be observed (F|gure 19) that is considered highly suggestive of syphilis [66,67]. However, it also can be observed in ascending infections [68,69].…”

Section: Syphilismentioning

confidence: 94%

The Placenta in Hematogenous Infections

Bittencourt

Garcia

2002

Pediatric Pathology & Molecular Medicine

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Although congenital infections have been known since ancient times, at present they constitute an evolution due to the broadening of diagnostic methods. Also, the histopathological examination of selected placentas has increased in perinatal pathology. All placentas should be examined grossly by the obstetrician or the neonatologist who must select the specimens to be sent for pathologic examination. The indications for selection at delivery to detect hematogenous infection are listed in Table 1. The placentas that do not meet guidelines for pathologic examination must be kept stored at 40 degrees C for at least 72 h. This routine ensures that the placentas of asymptomatic newborns who might present early manifestations suggestive of infection would be submittedfor pathologic examination.

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Testing Umbilical Cords for Funisitis due to Treponema pallidum Infection, Bolivia

Cited by 21 publications

References 4 publications

Immunohistochemical evidence of Clostridium sp, Staphylococcus aureus, and group A Streptococcus in severe soft tissue infections related to injection drug use

Immunohistochemical evidence of Clostridium sp, Staphylococcus aureus, and group A Streptococcus in severe soft tissue infections related to injection drug use

Analyses of levels of thyroid hormones and its receptor expression in puerperants and newborns from an e-waste dismantling site

The Placenta in Hematogenous Infections

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