Testing the Underlying Chemical Principles of the Biotic Ligand Model (BLM) to Marine Copper Systems: Measuring Copper Speciation Using Fluorescence Quenching

Tait, Tara; McGeer, James C.; Smith, D. Scott

doi:10.1007/s00128-017-2262-8

Cited by 9 publications

(3 citation statements)

References 21 publications

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“…Finally, to characterize potential differences in the Ni-binding properties of the dissolved organic matter (DOM) in UBC and UM waters, Fluorescence Excitation Emission Matrices (FEEMs) were measured using a spectrofluorometer (Varian ECLIPSE Cary fluorescence spectrophotometer [Varian Inc., Old Oak, NJ]) and a 1 cm quartz cuvette (Starna Cells Inc., Atascadero, CA) (Tait et al 2018). For scans, the excitation monochrometer was varied from 200 to 450 nm in 10 nm increments, and for each excitation wavelength the sample emission was recorded at 250 to 600 nm in 1 nm increments.…”

Section: Physicochemical Analyses and Free Ni 2+ Measurementsmentioning

confidence: 99%

A Mystery Tale: Nickel Is Fickle When Snails Fail—Investigating the Variability in Ni Toxicity to the Great Pond Snail

Crémazy

Brix

Smith

et al. 2020

Integr Envir Assess & Manag

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Dissolved Ni concentrations inhibiting the growth of juvenile great pond snails (Lymnaea stagnalis) have been documented to vary from about 1 to 200 µg L −1 Ni. This variability makes L. stagnalis either a moderately sensitive or the most sensitive freshwater species to chronic Ni exposure tested to date. Given the role of sensitive species in environmental risk assessment frameworks, it is particularly important to understand this variability, i.e., to characterize the factors that modulate Ni toxicity and that may confound toxicity test outcomes when uncontrolled. In the present study, we tested if this variability was due to analytical (growth calculation: biomass versus growth rate), environmental (water quality), lab-specific practices, and/or snail population differences among earlier studies. Specifically, we reanalyzed previously published Ni toxicity data and conducted additional measurements of Ni aqueous speciation, short-term Ni uptake, and chronic Ni toxicity with test waters and snail cultures used in previous studies. Corrections for Ni bioavailability and growth calculations explained a large degree of variability in the published literature. However, a residual 16-fold difference remained puzzling between 2 studies: Niyogi et al. (2014) (low ECxs) and Cré mazy et al. (2018) (high ECxs). Indeed, differences in metal bioavailability due to water chemistry, lab-specific practices, and snail population sensitivity could not explain the large variation in Ni toxicity in these 2 very similar studies. Other potentially important toxicity-modifying factors were not directly evaluated in the present work: test duration, diet, snail holding conditions, and snail age at onset of testing. The present analysis highlights the need for further studies to elucidate 1) the mechanisms of growth inhibition in Ni-exposed L. stagnalis and 2) the important abiotic and biotic factors affecting this biological response. Until these processes are understood, substantial uncertainties will remain about inclusion of this species in Ni environmental risk assessment. Integr Environ Assess Manag 2020;16: 983-997.

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Section: Physicochemical Analyses and Free Ni 2+ Measurementsmentioning

confidence: 99%

A Mystery Tale: Nickel Is Fickle When Snails Fail—Investigating the Variability in Ni Toxicity to the Great Pond Snail

Crémazy

Brix

Smith

et al. 2020

Integr Envir Assess & Manag

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“…Additional C DGT Cu EC50s, determined using seawater samples covering the tested DOC range, as well as determination of an M. edulis SMAV are recommended for model validation and verification that an adequate protection level is provided by the C DGT CMC, respectively. The highest priority next step, in a pragmatic regulatory aspect, is validation of the model through laboratory screening of seawater samples sourced to be representative of the DOC range in the current model, with the addition of fluorescence quenching or analogous comeasurements to characterize binding strength and ligand density advised for DGT performance confirmation (Tait et al 2018).…”

Section: Toxic Effects As C Dgt Cumentioning

confidence: 99%

Effects of Dissolved Organic Carbon on Copper Toxicity to Embryos of Mytilus galloprovincialis as Measured by Diffusive Gradient in Thin Films

Strivens

Hayman

Johnston

et al. 2019

Enviro Toxic and Chemistry

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Diffusive gradient in thin films (DGT) potentially better quantifies bioavailable copper (Cu) in seawater. Laboratory exposure of DGTs and Mytilus galloprovincialis embryos at varying concentrations of dissolved organic carbon and Cu were performed to resolve the degree to which mimicry of toxicity buffering occurs in passive sampler quantification. The results provide preliminary median effect concentrations (EC50s) ranging from 4.8 to 11.5 µg/L as CDGT Cu over the span of 0.896 to 8.36 mg/L DOC. Environ Toxicol Chem 2019;00:1‐6. Published 2019 Wiley Periodicals, Inc. on behalf of SETAC. This article is a US government work and, as such, is in the public domain in the United States of America.

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“…In water bodies, the speciation of copper strongly affects the ability of copper to create toxicity [ 30 , 31 ]. Copper is a transition metal with three oxidation states, namely Cu(0) (solid metal state), Cu(I) (cuprous ion), and Cu(II) (cupric ion).…”

Section: Introductionmentioning

confidence: 99%

Review of Copper and Copper Nanoparticle Toxicity in Fish

et al. 2020

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This review summarizes the present knowledge on the toxicity of copper and copper nanoparticles (CuNPs) to various fish species. In previous decades, the excessive usage of metal and metallic nanoparticles has increased significantly, increasing the probability of the accumulation and discharge of metals in various trophic levels of the environment. Due to these concerns, it is important to understand the toxicity mechanisms of metals and metallic nanoparticles before they lead to unhealthy effects on human health. In this review paper, we specifically focus on the effect of metal copper and CuNPs on different fish organs under different physiochemical parameters of various water bodies. Nowadays, different forms of copper have distinctive and specific usages, e.g., copper sulfate is a well-established pesticide which is used to control the growth of algae in lakes and ponds. Deactivating the fungi enzymes prevents fungal spores from germinating. This process of deactivation is achieved via the free cupric ions, which are established as the most toxic forms of copper. Complexes of copper with other ligands may or may not be bioavailable for use in aquatic organisms. On the other hand, CuNPs have shown cost-effectiveness and numerous promising uses, but the toxicity and availability of copper in a nanoparticle form is largely unknown, Additionally, physiochemical factors such as the hardness of the water, alkalinity, presence of inorganic and organic ligands, levels of pH, and temperature in various different water bodies affect the toxicity caused by copper and CuNPs. However, comprehensive knowledge and data regarding the pattern of toxicity for copper metal ions and CuNPs in marine organisms is still limited. In this review, we carry out a critical analysis of the availability of the toxicological profiles of copper metal ions and CuNPs for different fishes in order to understand the toxicity mechanisms of copper and CuNPs. We believe that this review will provide valuable information on the toxicological profile of copper, which will further help in devising safe guidelines for the usage of copper and CuNPs in a sustainable manner.

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Testing the Underlying Chemical Principles of the Biotic Ligand Model (BLM) to Marine Copper Systems: Measuring Copper Speciation Using Fluorescence Quenching

Cited by 9 publications

References 21 publications

A Mystery Tale: Nickel Is Fickle When Snails Fail—Investigating the Variability in Ni Toxicity to the Great Pond Snail

A Mystery Tale: Nickel Is Fickle When Snails Fail—Investigating the Variability in Ni Toxicity to the Great Pond Snail

Effects of Dissolved Organic Carbon on Copper Toxicity to Embryos of Mytilus galloprovincialis as Measured by Diffusive Gradient in Thin Films

Review of Copper and Copper Nanoparticle Toxicity in Fish

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