Testing the role of the backbone length using bidentate and tridentate ligands in manganese-catalyzed asymmetric hydrogenation

Császár, Zsófia; Kovács, Regina; Fonyó, Máté; Simon, József; Bényei, Attila; Lendvay, György; Bakos, József; Farkas, Gergely

doi:10.1016/j.mcat.2022.112531

Cited by 2 publications

(1 citation statement)

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“…Zhong et al highlighted the importance of steric characteristics of the terminal ligand substituents. In 2022, Farkas [48] et al developed some simple alkane‐diyl based P,N and P,N,N‐ligands and applied them in the Mn‐catalyzed asymmetric hydrogenation of ketones 1 . The results showed that the length of the N‐(CH 2 )n‐N backbone of P,N,N ligands strongly influences the coordination mode and catalytic reactivity.…”

Section: Asymmetric Hydrogenation Of C=o Bondsmentioning

confidence: 99%

Chiral P,N,N‐Ligands for Asymmetric Hydrogenation

Liang,

Hou,

et al. 2024

Adv Synth Catal

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The chiral P,N,N‐ligands represented a new type of tridentate ligand developed in recent years and displayed wide utilities in asymmetric catalysis. In the past decades, numerous chiral P,N,N‐ligands with ferrocene, phenethylamine and spiro backbones were synthesized by addition of an aminopyridine, imidazole or diamines coordinating group. These chiral tridentate P,N,N‐ligands showed excellent performance in the ruthenium, iridium, manganese, or cobalt‐catalyzed asymmetric hydrogenations. A wide range of substrates, including simple ketones, α‐halogenated ketones, α‐hydroxy ketones, α‐ or β‐amino ketones, α‐, γ‐, or δ‐keto acids, α‐ or β‐keto amides, β‐ or δ‐keto esters, α‐ or β‐enones, olefins, imines, quinolines and indoles, could be hydrogenated to afford the corresponding chiral products with high yields and enantioselectivities. In this review, progress on the asymmetric hydrogenation of C=O, C=N, C=C bonds with chiral tridentate P,N,N‐ligands was summarized.

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Section: Asymmetric Hydrogenation Of C=o Bondsmentioning

confidence: 99%