In recent years, due to factors such as increases in greenhouse gas (GHG) and carbon dioxide (CO 2) emissions, global warming and climate changes has become a major threat for all countries. However, contrary to the deep-seated belief that human impact on the environment is negative and progressive, recent empirical research shows that certain types of pollutants follow an inverted-U shape or Environmental Kuznets curve (EKC), as income grows. The EKC hypothesis postulates that environmental degradation (pollution) increases up to a certain level, as income goes up; after that, it decreases. Thus, using the EKC hypothesis as a theoretical framework and applying Pooled Mean Group (PMG) approach, this paper examines the nexus between CO 2 emissions, economic growth, Foreign Direct Investment (FDI) and total population. The study uses panel data of 12 East African countries over the period 1981-2016. Our empirical result shows that there exists a monotonically increasing relationship between CO 2 emissions and economic growth both in the short-run and long-run, contrary to what is claimed by the EKC hypothesis. Moreover, per capita CO 2 emissions increase positively with respect to FDI and total population in the long-run. The result of the study also reports the existence of unidirectional causalities running from per capita GDP, FDI and total population to per capita CO 2 emissions in the long-run, while unidirectional short-run causalities was observed from GDP and FDI to CO 2 emissions, without any feedback effects. Therefore, these unidirectional causalities imply that CO 2 emission reduction or abatement measures can be implemented without having any adverse effect on the real output growth or economic growth, in East Africa.