Testing the diathesis‐stress model: 5‐HTTLPR, childhood emotional maltreatment, and vulnerability to social anxiety disorder

Reinelt, Eva; Stopsack, Malte; Aldinger, Maren; John, Ulrich; Grabe, Hans J.; Barnow, Sven

doi:10.1002/ajmg.b.32142

Cited by 24 publications

(15 citation statements)

References 40 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…The triallelic 5‐HTTLPR genotype proportions (L A L A , n = 1881; L A L G , n = 480; SL A , n = 2962; L G L G , n = 58; SL G , n = 394; SS, n = 1262) were not in Hardy–Weinberg equilibrium ( P = 0.001). However, the proportion of L A (51%), L G (7%), and S (42%) alleles were similar to the proportions found in a previous Danish study (Rasmussen, Bagger, Tanko, Christiansen, & Werge, ) and the distribution according to transcriptional activity (high: 27%, intermediate: 49%, low: 24%) resembles previous observations in Northern European populations (Araya et al., ; Bukh et al., ; Reinelt et al., ).…”

Section: Methodssupporting

confidence: 90%

Genetic variants in5-HTTLPR,BDNF,HTR1A,COMT, andFKBP5and risk for treated depression after cancer diagnosis

et al. 2017

View full text Add to dashboard Cite

Background The role of gene–environment interactions in the pathogenesis of depression is unclear. Previous studies addressed vulnerability for depression after childhood adversity and stressful life events among carriers of numerous specific genetic variants; however, the importance of individual genetic variants, the environmental exposures with which they interact, and the magnitude of the risk conveyed by these interactions remain elusive. Methods We included 7,320 people with a first primary cancer identified in the prospective Diet, Cancer and Health study in an exposed-only cohort study. The mean age of the individuals was 68 years (5th, 95th percentiles: 58, 78) at cancer diagnosis. Using Cox regression models and cumulative incidence plots, we analyzed the associations between genetic variants in 5-HTTLPR, BDNF, HTR1A, COMT, and FKBP5 and use of antidepressants as well as hospital contact for depression after diagnosis of cancer. Results Overall, we observed no statistically significant associations, with nonsignificant hazard ratio estimates for use of antidepressants of 0.95–1.07. Conclusions This study of elderly people indicates that it is unlikely that the investigated genetic variants are clinically relevantly associated with depression after diagnosis of cancer. The mechanisms for gene–environment interactions in younger individuals are probably different, and we advise caution in extrapolating our results to early life stress. However, conclusion from the present study might be generalizable to elderly persons exposed to other stressful life events.

show abstract

Section: Methodssupporting

confidence: 90%

Genetic variants in5-HTTLPR,BDNF,HTR1A,COMT, andFKBP5and risk for treated depression after cancer diagnosis

et al. 2017

View full text Add to dashboard Cite

show abstract

“…Similarly, for participants with SAD, most of the evaluated studies ( n = 5 [3,7,21,43,61]) indicated a higher prevalence of EETs in the SAD group compared with the control group. An exception was one study [43], which found no differences between the groups with respect to physical and sexual traumas.…”

Section: Resultsmentioning

confidence: 99%

“…To conduct a meta-analysis of emotional trauma and ADs, six studies [3,21,43,61,67,71] were analyzed and no evidence of publication bias was found among these studies (P > 0.05).…”

Section: Emotional Traumamentioning

confidence: 99%

Are There Associations Between Early Emotional Trauma and Anxiety Disorders? Evidence from a Systematic Literature Review and Meta-Analysis

Fernandes

Osório

2015

Eur. psychiatr.

View full text Add to dashboard Cite

EET is a risk factor for ADs, underscoring the importance of preventive measures to combat the development of these disorders. Moreover, the identification of EETs among patients with ADs is essential for implementing remedial measures to minimize the impact and damage arising from this association by decreasing the risk and severity of symptoms and to improve the response rate to treatment of ADs.

show abstract

“…31 Anxiety spectrum disorders are triggered by stressors related with life events that cause fear of loss of control and seem to be associated with childhood trauma, particularly emotional abuse and parental rejection. 32,33 Quality stress factors that predispose to anxiety disorders in young population appear to be more related to fear of loss of health or destabilization in the parental environment (health problems, financial hardship, parental hostility). 34 History of child abuse is considered a risk factor for the appearance of both anxiety disorders and depression 32 for individuals who are exposed to the stressful military environment.…”

Section: Discussionmentioning

confidence: 99%

“…32,33 Quality stress factors that predispose to anxiety disorders in young population appear to be more related to fear of loss of health or destabilization in the parental environment (health problems, financial hardship, parental hostility). 34 History of child abuse is considered a risk factor for the appearance of both anxiety disorders and depression 32 for individuals who are exposed to the stressful military environment. The onset of depressive symptomatology is associated with life events related to the loss of an important person or change in life role.…”

Section: Discussionmentioning

confidence: 99%

The diathesis-stress model in the emergence of major psychiatric disorders during military service

Chasiropoulou¹,

Siouti²,

Mougiakos³

et al. 2020

Psychiatriki

View full text Add to dashboard Cite

E xisting evidence and the diathesis-stress model hypothesis suggest that stress as an environmental factor may trigger the onset of psychiatric disorders, such as psychosis spectrum disorders, mood disorders, anxiety disorders, in people with an underlying vulnerability. The purpose of this study was to determine the period of time during military service at which symptomatology of clinical significance is more often developed, considering that stress of service and adaptation to its requirements is common to all army recruits. A retrospective file study for the years 2017-2018 was conducted in order to identify male soldiers who were hospitalized in the psychiatric clinic of 414 Athens Military hospital and diagnosed as F20-29, F30-39 and F40-48 according to ICD-10. The number of hospitalizations per clinical diagnosis and the time of onset relatively to the month of military service were examined. A total of 139 cases were screened, 119 of which had disorders falling into the diagnostic categories F20-29, F30-39 and F40-48. 53% of total hospitalizations took place within the first two months of a nine-month military service. It was found that the risk of disorder onset within the first two months of military service was statistically higher (OR=0.210, p=0.001) for a schizophrenic spectrum disorder (F20-29) compared to F30-39 and F40-48 disorders. After adjusting for potential confounders, such as heritability for psychiatric disorders, urbanicity, history of substance use or age, the risk for hospitalization within the first two months continued to be significantly predicted by F20-29 disorder (OR=0.255, p=0.022) compared to other diagnoses. Individuals vulnerable in developing a psychotic disorder appear to have lower stress tolerance and may manifest an earlier disease onset, when exposed to the stress of military service compared to subjects predisposed to develop mood or anxiety disorders. Stress during military service is of major importance for the emergence of the whole psychopathology spectrum, particularly in vulnerable individuals. The development of prevention and early intervention strate

show abstract

Testing the diathesis‐stress model: 5‐HTTLPR, childhood emotional maltreatment, and vulnerability to social anxiety disorder

Cited by 24 publications

References 40 publications

Genetic variants in5-HTTLPR,BDNF,HTR1A,COMT, andFKBP5and risk for treated depression after cancer diagnosis

Genetic variants in5-HTTLPR,BDNF,HTR1A,COMT, andFKBP5and risk for treated depression after cancer diagnosis

Are There Associations Between Early Emotional Trauma and Anxiety Disorders? Evidence from a Systematic Literature Review and Meta-Analysis

The diathesis-stress model in the emergence of major psychiatric disorders during military service

Contact Info

Product

Resources

About