Testing the daily stress stimulus theory of bone adaptation with natural and experimentally controlled strain histories

Adams, Douglas; Spirt, Adrienne A.; Brown, Thomas; Fritton, Susannah P.; Rubin, Clinton T.; Brand, Richard A.

doi:10.1016/s0021-9290(97)00004-3

Cited by 59 publications

(44 citation statements)

References 30 publications

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“…Reducing m from 4.5, a value suggested for low-frequency loading, (Beaupre et al, 1990), to m ¼ 1, a value suggested for high-frequency loading (Qin et al, 1998), the strength of the 90 Hz stimulus would still have been 43% greater than the 45 Hz stimulus and m would have to drop below 0.66 before the relation reverses and the 90 Hz stimulus becomes more osteogenic. Whether a dynamically adaptive index m can be realized biologically or whether our results add to the experimental inconsistencies that cannot be explained with the daily stress stimulus hypothesis (Adams et al, 1997;Gross et al, 2004) remains to be determined.…”

Section: Discussionmentioning

confidence: 96%

Low-magnitude mechanical signals that stimulate bone formation in the ovariectomized rat are dependent on the applied frequency but not on the strain magnitude

Judex

Lei

Han

et al. 2007

Journal of Biomechanics

251

226

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Section: Discussionmentioning

confidence: 96%

Low-magnitude mechanical signals that stimulate bone formation in the ovariectomized rat are dependent on the applied frequency but not on the strain magnitude

Judex

Lei

Han

et al. 2007

Journal of Biomechanics

251

226

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“…It is generally accepted that this relationship between bone morphology (density/micro-architecture) and loading is the result of a local load-adaptive bone remodeling process regulated and carried out by bone cells in such a way that bone tissue is added to high-load locations and removed from low-load locations ('Wolff's law') (Schulte et al 2011;Adams et al 1997;Forwood and Turner 1995;Goldstein et al 1991;Rubin and Lanyon 1987;Frost 1987;Wolff 1892). This implies that, eventually, all bone tissue should be loaded uniform, thus producing a bone morphology that is optimized for the external loading history that it is subjected to.…”

Section: Introductionmentioning

confidence: 99%

Bone morphology allows estimation of loading history in a murine model of bone adaptation

Christen

Rietbergen

Lambers

et al. 2011

Biomech Model Mechanobiol

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Bone adapts its morphology (density/microarchitecture) in response to the local loading conditions in such a way that a uniform tissue loading is achieved ('Wolff's law'). This paradigm has been used as a basis for bone remodeling simulations to predict the formation and adaptation of trabecular bone. However, in order to predict bone architectural changes in patients, the physiological external loading conditions, to which the bone was adapted, need to be determined. In the present study, we developed a novel bone loading estimation method to predict such external loading conditions by calculating the loading history that produces the most uniform bone tissue loading. We applied this method to murine caudal vertebrae of two groups that were in vivo loaded by either 0 or 8 N, respectively. Plausible load cases were sequentially applied to micro-finite element models of the mice vertebrae, and scaling factors were calculated for each load case to derive the most uniform tissue strainenergy density when all scaled load cases are applied simultaneously. The bone loading estimation method was able to predict the difference in loading history of the two groups and the correct load magnitude for the loaded group. This result suggests that the bone loading history can be estimated from its morphology and that such a method could be useful for predicting the loading history for bone remodeling studies or at sites where measurements are difficult, as in bone in vivo or fossil bones.

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“…The value m¼4 has typically been used in previous studies (Beaupré et al, 1990;Carpenter and Carter, 2008;Mikić and Carter, 1995). The daily effective stress stimulus has been evaluated for some experimental animal data (Adams et al, 1997;Konieczynski et al, 1998). Osteogenic index (OI) was presented by Turner (1998) and Turner and Robling (2003).…”

Section: Introductionmentioning

confidence: 99%

Daily impact score in long-term acceleration measurements of exercise

Ahola

Korpelainen

Vainionpää

et al. 2010

Journal of Biomechanics

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Testing the daily stress stimulus theory of bone adaptation with natural and experimentally controlled strain histories

Cited by 59 publications

References 30 publications

Low-magnitude mechanical signals that stimulate bone formation in the ovariectomized rat are dependent on the applied frequency but not on the strain magnitude

Low-magnitude mechanical signals that stimulate bone formation in the ovariectomized rat are dependent on the applied frequency but not on the strain magnitude

Bone morphology allows estimation of loading history in a murine model of bone adaptation

Daily impact score in long-term acceleration measurements of exercise

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