Testing the association of serum uric acid levels with behavioral and clinical characteristics in subjects with major affective disorders: A cross-sectional study

Bartoli, Francesco; Crocamo, Cristina; Bava, Mattia; Castagna, Gloria; Brita, Carmen Di; Riboldi, Ilaria; Trotta, Giulia; Verrengia, Enrica; Clerici, Massimo; Carrà, Giuseppe

doi:10.1016/j.psychres.2018.08.039

Cited by 17 publications

(16 citation statements)

References 40 publications

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“…Moreover, several potential confounders, such as variables associated with metabolism and renal function, were taken into account. Our results were in general agreement with previous research that revealed an inverse relationship between UA levels and suicidal ideation severity in patients with major affective disorders (Bartoli et al 2018c; Bartoli et al 2018d). In addition, a decrease in the output of UA was also found in the urine of nonchemical suicide victims, although only 12 patients were included (Lis et al 1975).…”

Section: Discussionsupporting

confidence: 93%

“…It is well known that females are more likely to suffer from depression and to attempt suicide (Bernal et al 2007;Kringlen et al 2001) than males, and sex is one of the most important factors affecting serum UA levels. Previous evidence indicates that UA levels in men are higher than those in women in both the normal population and MDD patients (Bartoli et al 2018c). Moreover, antidepressant treatment may significantly affect serum UA levels (Bartoli et al 2018e).…”

Section: Introductionmentioning

confidence: 94%

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Association of serum uric acid levels with suicide risk in female patients with major depressive disorder: a comparative cross-sectional study

Chen

Feng²,

Zhang

et al. 2020

Preprint

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Background: Individuals with major depressive disorder (MDD) have a high suicide risk. Some evidence suggests that uric acid (UA) may be involved in the pathophysiology of MDD. The purpose of this study was to evaluate whether serum UA levels were associated with suicide risk in MDD patients.Methods: One hundred four female patients with MDD (52 patients with suicide risk and 52 patients without suicide risk) and 52 healthy individuals were included in this study. The suicide risk was evaluated by Mini International Neuropsychiatric Interview (M.I.N.I). Fasting serum levels of UA, as well as glucose, lipid and renal function indicators were measured.Results: Serum UA levels in MDD patients with suicide risk (245.01 ± 55.44 μmol/L) were significantly lower than those in MDD patients without suicide risk (274.17 ± 72.65 μmol/L) (p = 0.017) and healthy controls (271.42 ± 55.25 μmol/L) (p = 0.030). There was no difference in serum UA levels between the MDD patients without suicide risk and healthy controls (p = 0.821). Binary logistic regression analysis revealed a significant relationship between suicide risk and decreased serum UA levels (OR = 0.989, p = 0.010) in MDD patients.Conclusion: Decreased serum UA levels were associated with suicide risk in MDD patients. Purinergic system dysfunction may be involved in the neurobiological basis of suicide risk in these patients.

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Section: Discussionsupporting

confidence: 93%

Section: Introductionmentioning

confidence: 94%

Association of serum uric acid levels with suicide risk in female patients with major depressive disorder: a comparative cross-sectional study

Chen

Feng²,

Zhang

et al. 2020

Preprint

View full text Add to dashboard Cite

show abstract

“…According to the WHO, of all deaths from suicide, 22% can be attributed to the use of alcohol, which means that one in every 5 suicides in the population could be avoided if alcohol had not been consumed [42]. It is estimated that between 34% -56% of suicide bombers abuse or are addicted to alcohol, and the risk of suicide bombers in this group is between 2% -3.4%, which is 6 times higher than in people who are not burdened with this diagnosis [43,44,45,46]. The simultaneous occurrence of affective disorders increases the level of impulsivity and auto-aggression [47].…”

Section: Ethanol Effects On Auto-aggression Behaviourmentioning

confidence: 99%

Ethanol as a stimulus to risky and auto-aggressive behaviour

Lasota¹,

Pawłowski²,

Mirowska‐Guzel³

et al. 2021

Ann Agric Environ Med.

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According to the World Health Organization (WHO), ethyl alcohol occupies the third place among health risks for the general population, causing damage to health as well as social damage. Ethanol is also considered the greatest risk factor in injuries. Both alcohol and its main metabolite, acetaldehyde, are directly toxic to tissues and lead to several systemic pathologies. Alcohol abuse may also lead to mental health disorders. Although one-in-eight adult Poles abstains from drinking alkohol, 10-20% of adult Poles drink alcohol regularly. It is estimated that this group includes about 900,000 addicts, and over 2,000,000 people who drink alcohol at a risky or harmful level. It affects their occurrence and their consequences Drinkdriving is one of the problems most often raised, although alcohol is a documented risk factor in pedestrian accidents. It is also an important risk factor for suicidal behaviour with people under the influence of alcohol choosing more radical and effective methods of committing suicide, such as hanging or 'throwing themselves under a moving vehicle.' Only properly selected and consistently taken preventive actions can improve the tragic statistics related to ethanol stimulating risky and auto-aggressive behaviours. It is also necessary to improve the system for reporting such events because only reliable statistics enable proper assessment of the scale of the problem, and the effectiveness of these activities.

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“…It is well known that females are more likely to suffer from depression and to attempt suicide (27,28) than males, and sex is one of the most important factors affecting serum UA levels. Previous evidence indicates that UA levels in men are higher than those in women in both the normal population and MDD patients (26). Moreover, antidepressant treatment may signi cantly affect serum UA levels (29).…”

mentioning

confidence: 96%

“…To date, few studies have been designed to explore the association between UA and suicide. Recently, promising ndings from Bartoli and his team have shown an inverse relationship between UA levels and severity of suicidal ideation in individuals with major affective disorders (25,26) . However, some confounding factors such as glucose and lipid metabolism, renal function and prescribed medications were not controlled in these studies.…”

mentioning

confidence: 99%

Association of serum uric acid levels with suicide risk in female patients with major depressive disorder: a comparative cross-sectional study

Chen

Feng²,

Zhang

et al. 2020

Preprint

View full text Add to dashboard Cite

Background: Individuals with major depressive disorder (MDD) have a high suicide risk. Some evidence suggests that uric acid (UA) may be involved in the pathophysiology of MDD. The purpose of this study was to evaluate whether serum UA levels were associated with suicide risk in MDD patients.Methods: One hundred four female patients with MDD (52 patients with suicide risk and 52 patients without suicide risk) and 52 healthy individuals were included in this study. The suicide risk was evaluated by Mini International Neuropsychiatric Interview (M.I.N.I.). Fasting serum levels of UA, as well as glucose, lipid and renal function indicators were measured.Results: Serum UA levels in MDD patients with suicide risk (245.01 ± 55.44 μmol/L) were significantly lower than those in MDD patients without suicide risk (274.17 ± 72.65 μmol/L) (p = 0.017) and healthy controls (271.42 ± 55.25 μmol/L) (p = 0.030). There was no difference in serum UA levels between the MDD patients without suicide risk and healthy controls (p = 0.821). Binary logistic regression analysis revealed a significant relationship between suicide risk and decreased serum UA levels (OR = 0.989, p = 0.010) in MDD patients.Conclusion: Decreased serum UA levels were associated with suicide risk in MDD patients. Purinergic system dysfunction may be involved in the neurobiological basis of suicide risk in these patients.

show abstract

Testing the association of serum uric acid levels with behavioral and clinical characteristics in subjects with major affective disorders: A cross-sectional study

Cited by 17 publications

References 40 publications

Association of serum uric acid levels with suicide risk in female patients with major depressive disorder: a comparative cross-sectional study

Association of serum uric acid levels with suicide risk in female patients with major depressive disorder: a comparative cross-sectional study

Ethanol as a stimulus to risky and auto-aggressive behaviour

Association of serum uric acid levels with suicide risk in female patients with major depressive disorder: a comparative cross-sectional study

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