Testing Stenting and Flow Diversion Using a Surgical Elastase-Induced Complex Fusiform Aneurysm Model

Abstract

Challenging fusiform aneurysms can be created in rabbits by using a surgical modification of the elastase method.

Transient in-stent stenosis at mid-term angiographic follow-up in patients treated with SILK flow diverter stents: incidence, clinical significance and long-term follow-up

“…A few studies on FD stents have demonstrated similar histological findings 4. In a recent animal study, neointimal thickness was found to be more extensive in FDs compared with high-porosity stents 19. As ISS is reported in the different FD stent devices, we believe that ISS is inherent to all FD stents likely due to increased strut density.…”

Preclinical extracranial aneurysm models for the study and treatment of brain aneurysms: A systematic review

“…Similarly, Fahed et al. 81 created a complex fusiform rabbit aneurysm model that permitted more comprehensive testing for flow diverters (Figure 5, E6; Supplementary Figure E6). Avery et al.…”

“…With the emergence of novel endovascular technologies that extended the indications for treatment to a broader range of intracranial aneurysm (IA) morphologies, new preclinical models were needed. More recently fusiform 81 and curved sidewall 82 aneurysm models were designed in rabbits and dogs. Darsaut et al.…”

“…With the emergence of novel endovascular technologies that extended the indications for treatment to a broader range of intracranial aneurysm (IA) morphologies, new preclinical models were needed. More recently fusiform 81 and curved sidewall 82 aneurysm models were designed in rabbits and dogs. Darsaut et al 83 introduced a giant fusiform model that used a rhomboid venous patch sutured to the anterior aspect of the lingual artery that allowed testing of flow diverters (Figure 5, E5; Supplementary Figure E5A).…”

“…To test flow diverter treatment of aneurysms with side branches, Darsaut et al 85 created complex terminal aneurysms that featured a side branch originating from the aneurysm sac (Figure 5, E8; Supplementary Figure E8). Similarly, Fahed et al 81 created a complex fusiform rabbit aneurysm model that permitted more comprehensive testing for flow diverters (Figure 5, E6; Supplementary Figure E6). Avery et al 86 presented a refined fusiform aneurysm model by periarterial application of combined elastase and CaCl 2 in a rabbit CCA.…”