Testing Procedures and the Interpretation of Behavioral Data

Norrsell, Ulf

doi:10.1007/978-1-4615-7723-2_9

Cited by 4 publications

(2 citation statements)

References 11 publications

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“…The combined practice effects of rehabilitation and the transient effects of the lesion allowed the monkeys to perform slightly better than when they ended preinfarct training. Extensive pre-infarct training, as experienced by the monkeys in this study, may have contributed to a pre-operative "overtraining" effect which has been shown to facilitate recovery of function compared to naive animals (Norrsell 1978;Schulkin 1989). Intensive training was used in the present study and in the Nudo et al (1996b) study to maximize the initial effects of the lesion by reducing baseline variance, and to insure that the monkeys would be adequately adapted to their restraint jackets during post-infarct Klüver board training.…”

Section: Behavioral Recovery After Delayed Trainingmentioning

confidence: 90%

Behavioral and neurophysiological effects of delayed training following a small ischemic infarct in primary motor cortex of squirrel monkeys

et al. 2005

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A focal injury within the cerebral cortex results in functional reorganization within the spared cortex through time-dependent metabolic and physiological reactions. Physiological changes are also associated with specific post-injury behavioral experiences. Knowing how these factors interact can be beneficial in planning rehabilitative intervention after a stroke. The purpose of this study was to assess the functional impact of delaying the rehabilitative behavioral experience upon movement representations within the primary motor cortex (M1) in an established nonhuman primate, ischemic infarct model. Five adult squirrel monkeys were trained on a motor-skill task prior to and 1 month after an experimental ischemic infarct was induced in M1. Movement representations of the hand were derived within M1 using standard electrophysiological procedures prior to the infarct and again one and two months after the infarct. The results of this study show that even though recovery of motor skills was similar to that of a previous study in squirrel monkeys after early training, unlike early training, delayed training did not result in maintenance of the spared hand representation within the M1 peri-infarct hand area. Instead, delaying training resulted in a large decrease in spared hand representation during the spontaneous recovery period that persisted following the delayed training. In addition, delayed training resulted in an increase of simultaneously evoked movements that are typically independent. These results indicate that post-injury behavioral experience, such as motor skill training, may modulate peri-infarct cortical plasticity in different ways in the acute versus chronic stages following stroke.

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Section: Behavioral Recovery After Delayed Trainingmentioning

confidence: 90%

Behavioral and neurophysiological effects of delayed training following a small ischemic infarct in primary motor cortex of squirrel monkeys

et al. 2005

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“…The increased likelihood of behavioral recovery is due to two possibilities. First, animals (including humans) can often learn to use cues or strategies other than those the experimenter believes they are using (Norsell, 1978) in the performance of behavioral tasks used to assess the effects of a brain lesion, drug effect, or even a critical period manipulation. For example, a monocularly deprived animal might be tested for recovery of vision in the deprived eye with a pattern discrimination task.…”

Section: Continuation Versus Noncontinuation Of Plasticitymentioning

confidence: 99%

The critical period concept: Research, methodology, and theoretical issues.

Colombo

1982

Psychological Bulletin

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The concept of "critical periods" in postnatal behavioral development is reviewed. Evidence on the criteria and characteristics of critical period phenomena is considered with respect to endogenous and exogenous influences; methodology of critical period research is described and evaluated; and conceptual issues and problems are discussed in light of past attempts at subclassification of the field and recovery of function as a refutation of the critical period hypothesis. It is concluded that the critical period concept is viable if certain limitations are observed.

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Plasticity and Functional Mutability of Somatosensory Pathways

Norrsell¹

1991

Information Processing in the Somatosensory System

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Testing Procedures and the Interpretation of Behavioral Data

Cited by 4 publications

References 11 publications

Behavioral and neurophysiological effects of delayed training following a small ischemic infarct in primary motor cortex of squirrel monkeys

Behavioral and neurophysiological effects of delayed training following a small ischemic infarct in primary motor cortex of squirrel monkeys

The critical period concept: Research, methodology, and theoretical issues.

Plasticity and Functional Mutability of Somatosensory Pathways

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