Testing pitfalls and summary of guidance in lipid management

Smellie, W Stuart A

doi:10.1136/bmj.333.7558.83

Cited by 14 publications

(8 citation statements)

References 12 publications

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“…An audit was done to assess the proportion of abnormal results that were followed up correctly compared with the audit standard of a 100% correct follow-up rate. Correct follow-up was defined by guidelines that were taken from national guidelines, literature reviews or studies [6][7][8][9][10][11][12][13] and advice from experts in the relevant fields. The guidelines (see an online supplement to this paper) aim to ensure that patients get the correct follow-up by ensuring that appropriate blood tests and other investigations are done at the appropriate time and then referred, as required, to the correct service.…”

Section: Description Of Original Servicementioning

confidence: 99%

“…DS4) was devised in discussion with a biochemist specialising in lipid management at the University Hospital of North Durham and with reference to the literature. 10,13 Whether a patient gets lipid-lowering treatment depends on the 10-year cardiovascular risk calculations, and so information obtained on this through monitoring is forwarded to the GP with the referral.…”

Section: Guidelines For Follow-up Of Patients On Clozapinementioning

confidence: 99%

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Improving physical health monitoring in secondary care for patients on clozapine

Bolton

2011

Psychiatrist

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Aims and methodTo assess how well psychiatric teams follow up abnormal results from physical health monitoring of patients in a secondary care clozapine clinic compared with follow-up in a specialist secondary care physical health clinic, using an audit/re-audit method of comparison. Prevalence data for cardiovascular risk factors within the clinic population were also obtained.ResultsSubstantial and statistically significant (P < 0.01) improvements in follow-up of abnormal results were made following the introduction of a specialist clinic compared with treatment as usual. Prevalence of all cardiovascular risk factors among the patients on clozapine was very high compared with the general population.Clinical implicationsPatients on clozapine have significant and multiple cardiovascular risk factors, which may be best managed within a specialist secondary care physical health clinic that can follow up abnormal results and coordinate care across primary and secondary care.

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Section: Description Of Original Servicementioning

confidence: 99%

Section: Guidelines For Follow-up Of Patients On Clozapinementioning

confidence: 99%

Improving physical health monitoring in secondary care for patients on clozapine

Bolton

2011

Psychiatrist

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“…This guidance should be read in conjunction with reviews 1 and 3 of this series, which consider monitoring other aspects of cholesterol and triglyceride measurement, 20 21 which are accompanied by a further discussion in a case study on lipids in a series of articles in the BMJ. 22 When and how often should HDL-C be measured together with total cholesterol and LDL-C? We recommend that when assessing cardiovascular risk:…”

Section: High-density Lipoprotein Measurement and Treatmentmentioning

confidence: 99%

Best practice in primary care pathology: review 7

Smellie

Forth²,

Smart³

et al. 2006

J Clin Pathol

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This seventh best-practice review examines four series of common primary care questions in laboratory medicine: (1) blood count abnormalities 2; (2) cardiac troponins; (3) high-density lipoprotein cholesterol; and (4) viral diseases 2. The review is presented in a question-answer format, with authorship attributed for each question series. The recommendations are a précis of guidance found using a standardised literature search of national and international guidance notes, consensus statements, health policy documents and evidence-based medicine reviews, supplemented by Medline Embase searches to identify relevant primary research documents. The recommendations are not standards, but form a guide to be set in the clinical context. Most are consensus based rather than evidence based. They will be updated periodically to take account of new information.

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“…Individuals with neurodevelopmental disorders, including autism spectrum disorders (ASD), often display a wide range of symptom presentations, cognitive abilities, and behavioral profiles (Seelaar, Rohrer, Pijnenburg, Fox, & van Swieten, 2011; Smellie, 2006; Zetusky, Jankovic, & Pirozzolo, 1985). Characterizing these heterogeneous patterns represents a crucial question: Identification of distinct subgroups may provide important theoretical information regarding how underlying clinical impairments relate to prominent manifestations of disorders and may also provide critical information to facilitate targeted remediation of clinical symptoms within a specific subgroup.…”

mentioning

confidence: 99%

Quantitative Analysis of Heterogeneity in Academic Achievement of Children With Autism

Chen

Abrams

Rosenberg‐Lee

et al. 2018

Clinical Psychological Science

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Autism spectrum disorders (ASD) represent a quintessential example of a clinical population with diverse symptom presentations and marked variation in cognitive abilities. However, the extent literature lacks rigorous quantitative procedures for characterizing heterogeneity of cognitive abilities in these individuals. Here we employ novel clustering and cross-validation procedures to investigate the stability of heterogeneous patterns of cognitive abilities in reading and math in a relatively large sample (N=114) of children with ASD and matched controls (N=96). Our analysis revealed a unique profile of heterogeneity in ASD, consisting of a low-achieving subgroup with poor math skills compared to reading, and a high-achieving subgroup who showed superior math skills compared to reading. Verbal and central executive working memory skills further differentiated these subgroups. Findings provide insights into distinct profiles of academic achievement in children with ASD, with implications for educational practice and intervention, and provide a novel framework for quantifying heterogeneity in the disorder.

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Testing pitfalls and summary of guidance in lipid management

Cited by 14 publications

References 12 publications

Improving physical health monitoring in secondary care for patients on clozapine

Improving physical health monitoring in secondary care for patients on clozapine

Best practice in primary care pathology: review 7

Quantitative Analysis of Heterogeneity in Academic Achievement of Children With Autism

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