Testing on the Effectiveness and Biological Safety of New Granules Based on Oxyclozanide and Albendazole (Oxyclozal) in Mixed Invasion of Fascioliasis and Gastrointestinal Nematodes of Sheep

Abstract

In different regions of the Russian Federation, fasciolesis and strongilatoses of the gastrointestinal tract of young of sheep in the form of mono- and mixtinvasions are widespread endoparasitoses and are associated from fluctuations in the extensive index (EI) of 37.6-100%. The goal is to study the quantitative occurrence in young of sheep and to test the effectiveness of the granules based on oxyclozanide and albendazole (Oxyclosal) in mixed invasion of trematodes and strongilatoses of the gastrointestinal tract. Studies have shown that Fasciola and intestinal of strongilates of 14 species in young of sheep in the form of monoand mixed invasions are widespread with EI 27.5-64.3%. In young of sheep, mixtinvasion of fasciol and intestinal strongilatoses manifested itself with EI = 44.0% with an invasion (II) intensity, respectively, of 16,8±1,4 and 390,8 ± 16.2 ind./head. In the group of young sheep infected with mixtinvasion of fasciol and intestinal strongilates, the granules based on oxyclozanide and albendazole (Oxyclosal) at a dose of 15 mg / kg body weight had EE and IE of 100%. On the 5th day after a single deworming of eggs, fasciolesis and larvae of intestinal strongilatoses were not detected in feces. A dosage of 15 mg / kg body weight of the granules Oxyclosal should be recognized as an effective therapeutic dose.