Abstract:Using intracellular recording, we studied electrical activity of unidentified neurons of the Helix visceral ganglion under conditions of application of Viagra (sildenafil citrate). Neurotropic effects of Viagra were clearly pronounced at concentrations of 10 -5 and 10 -4 M; they were excitatory and reversible. In the case where the concentration was 10 -3 M, the effect of Viagra was converted into an inhibitory one; some hyperpolarization of the neuronal membrane, a decrease in the amplitude of action potentia… Show more
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