Testing Hypotheses and Estimating Parameters in Human Genetics if the Age of Onset is Random

Batschelet, Edward

doi:10.2307/2333898

Biometrika

1963

DOI: 10.2307/2333898

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Testing Hypotheses and Estimating Parameters in Human Genetics if the Age of Onset is Random

Edward Batschelet¹

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1966

1986

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“…The fact that the demographic structure of a particular sample has a strong effect on the age of onset distribution has been recognized by Batschelet (1963); Crowe and Smouse (1977); Heimbuch, Matthysse, and Kidd (1980);and Wendt, Landzettel, and Unterreiner (1959). Batschelet (1963) and Wendt et al (1959) suggested solving this problem by either restricting oneself to older individuals (who are presumably beyond the age at risk) or increasing the proportion of older individuals in the sample. Unfortunately, restricting oneself to older individuals is neither practical nor theoretically defensible because such populations may be biased by differential mortality.…”

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“…Thus, for example, studies that have reported relatively early onset age values may have obtained such results because there were few older individuals in the sample rather than because late onset depression is rare. The fact that the demographic structure of a particular sample has a strong effect on the age of onset distribution has been recognized by Batschelet (1963); Crowe and Smouse (1977); Heimbuch, Matthysse, and Kidd (1980); and Wendt, Landzettel, and Unterreiner (1959). Batschelet (1963) and Wendt et al.…”

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See 1 more Smart Citation

Age at first onset for nonbipolar depression.

Lewinsohn¹,

Duncan²,

Stanton³

et al. 1986

Journal of Abnormal Psychology

103

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The purpose of this study was to describe the onset age distribution for first episodes of unipolar depression for men and women. From a total of 6,742 participants ranging in age from 18 to 88 years, 2,046 were selected for a diagnostic interview on the basis of elevated scores on a self-report depression inventory and were diagnosed as per the Schedule for Affective Disorders and Schizophrenia and Research Diagnostic Criteria procedures. Of those interviewed, 1,012 were diagnosed as having suffered from a previous episode of depression. The Life Table method was used to describe the risks associated with different ages for developing an initial episode of depression. The results indicate that the hazard rates are very low through age 14 years, increase during adolescence (15-19 years) and young adulthood (20-24 years), peak between 45 and 55 years, and then decrease with increasing age, becoming zero at 80 years or older. The hazard rates for men and women differed, with women between the ages of 9 and 69 years having higher hazard rates than men between the same ages. The average age at onset for first episodes of depression for men and women did not differ.The age at which disorders have their initial onset is important epidemiological information. The potential importance of age at onset is recognized by the Diagnostic and Statistical Manual of Mental Disorders (DSM-III; American Psychiatric Association, 1980), which devotes a section to this aspect for each disorder even though in most instances relatively few empirical data are available for estimating the age of first onset distributions for the various disorders.Many theoretical and practical issues can be addressed if the age at onset distribution for a disorder is known. Such knowledge would have important public policy and planning implications for directing services toward the vulnerable age groups. In addition, there is evidence that the age at first onset for a disorder can have etiological implications. For example, with affective disorders there appears to be a stronger genetic component in those individuals who develop the disorder earlier in life relative to those who develop the disorder later in life (Gershon,

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confidence: 99%

mentioning

confidence: 99%

Age at first onset for nonbipolar depression.

Lewinsohn¹,

Duncan²,

Stanton³

et al. 1986

Journal of Abnormal Psychology

103

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Some Advances in the Statistical Analysis of Human Variation*

Vandenberg

1966

Annals of the New York Academy of Sciences

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Testing Hypotheses and Estimating Parameters in Human Genetics if the Age of Onset is Random

Cited by 2 publications

References 4 publications

Age at first onset for nonbipolar depression.

Age at first onset for nonbipolar depression.

Some Advances in the Statistical Analysis of Human Variation*

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