Testing Hippocampal Memory in Prodromal Dementia with Lewy Bodies

Bussè, Cinzia; Caffarra, Paolo; Rossi, Alice S.; Zorzi, Giovanni; Fragiacomo, Federica; Camporese, Giulia; Pompanin, Sara; Bernardo, Gian Antonio Di; Cagnin, Annachiara

doi:10.3233/jad-180166

Cited by 9 publications

(7 citation statements)

References 16 publications

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“…Donaghy et al 2018 2015only showed impairment in EF (g = −0.72; Stroop Colour test) and there were no significant differences in Jicha et al 2010after bias correction. MCI-LBs performed significantly better than MCI-AD on verbal memory outcome measures (immediate recall, delayed recall, and recognition) in three studies (Bussè et al, 2018;Cagnin et al, 2015;Yoon et al, 2015) with generally large ES (g = 0.66-3.80, mean g = 1.82).…”

Section: Mci-lb Resultsmentioning

confidence: 90%

“…Twenty-one variables showed poorer performance by MCI-LB relative to MCI-AD in visuospatial, attention, and psychomotor speed. Both Bussè et al (2018) and Cagnin et al (2015) reported poorer performance in MCI-LB in WM, visuospatial and visuoconstructive ability, and EF, with magnitudes ranging from medium (g = −0.56, Object Decision Visuospatial Test, Cagnin et al, 2015) to large (g = −0.95, Digit Span Backwards, Cagnin et al, 2015) and very large (g = −3.45, Pentagon Test number of angles, Busse, Hensel, Gühne, Angermeyer, & Riedel-Heller, 2006). Donaghy et al 2018 2015only showed impairment in EF (g = −0.72; Stroop Colour test) and there were no significant differences in Jicha et al 2010after bias correction.…”

Section: Mci-lb Resultsmentioning

confidence: 99%

“…Only six other studies (Bussè et al, 2018;Cagnin et al, 2015;Donaghy et al, 2018;Jicha et al, 2010;Sadiq et al, 2017;Yoon et al, 2015) resulted from the systematic review and used MCI-AD rather than a control group for comparison. This illustrates both the dearth of neuropsychological research in MCI-LB and the current focus on AD in the field.…”

Section: Mci-lbmentioning

confidence: 99%

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The Neuropsychological Profile of Mild Cognitive Impairment in Lewy Body Dementias

Ciafone

Little

Thomas

et al. 2019

J Int Neuropsychol Soc

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Objectives:Dementia with Lewy bodies (DLB) and Parkinson’s disease dementia (PDD) have substantial clinical and biological overlap, with cognitive deficits typically observed in the executive and visuospatial domains. However, the neuropsychological profiles of mild cognitive impairment (MCI) associated with these disorders are not well understood.Methods:This systematic review examined existing literature on cognition in MCI due to LB disease (MCI-LB) and PD (PD-MCI) using an electronic search of seven databases (Medline, Embase, Psychinfo, PubMed, ProQuest, Scopus, and ScienceDirect). MCI-LB results were reviewed narratively given the small number of resulting papers (n = 7). Outcome variables from PD-MCI studies (n = 13) were extracted for meta-analysis of standardised mean differences (SMD).Results:In MCI-LB, executive dysfunction and slowed processing speed were the most prominent impairments, while visuospatial and working memory (WM) functions were also poor. MCI-LB scored significantly lower on verbal memory tests relative to controls, but significantly higher than patients with MCI due to Alzheimer’s disease. Quantitative analysis of studies in PD-MCI showed a similar profile of impairment, with the largest deficits in visuospatial function (Benton Judgement of Line Orientation, SMD g = −2.09), executive function (Trail Making Test B, SMD g = −1.65), verbal ability (Naming Tests, SMD g = −0.140), and WM (Trail Making Test A, SMD g = −1.20). In both MCI-LB and PD-MCI, verbal and visuospatial memory retrieval was impaired, while encoding and storage appeared relatively intact.Conclusions:The findings of this systematic review indicate similar neuropsychological profiles in the MCI stages of DLB and PDD. Executive impairment may at least partially explain poor performance in other domains.

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Section: Mci-lb Resultsmentioning

confidence: 90%

Section: Mci-lb Resultsmentioning

confidence: 99%

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The Neuropsychological Profile of Mild Cognitive Impairment in Lewy Body Dementias

Ciafone

Little

Thomas

et al. 2019

J Int Neuropsychol Soc

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“…To investigate the individual contributions of encoding, consolidation, and retrieval mechanisms to the memory deficits of PD patients, we used the Free and Cued Selective Reminding Test (FCSRT; Buschke, Sliwinski, Kuslansky, & Lipton, 1997), a test widely used for the assessment of EM failure in mild cognitive impairment and dementia . This test has demonstrated high sensitivity and specificity to cognitive decline and dementia (Grober, Lipton, Hall, & Crystal, 2000), and is also a good tool to discriminate AD patients from other forms of dementia (Bussè et al, 2018;Lemos, Duro, Simões, & Santana, 2014;Teichmann et al, 2017). The FCSRT combined with the item-specific deficit approach (ISDA) introduced by Wright et al (2009) allows for the precise quantification of encoding, consolidation, and retrieval deficits.…”

Section: Introductionmentioning

confidence: 99%

Episodic Memory Impairment in Parkinson’s Disease: Disentangling the Role of Encoding and Retrieval

Siquier

Andrés

2020

J Int Neuropsychol Soc

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Objective: The source of episodic memory (EM) impairment in Parkinson’s disease (PD) is still unclear. In the present study, we sought to quantify specifically encoding, consolidation, and retrieval process deficits in a list-learning paradigm by a novel method, the item-specific deficit approach (ISDA). Methods: We applied the ISDA method to the Free and Cued Selective Reminding Test (FCSRT) in a sample of 15 PD patients and 15 healthy participants. Results: The results revealed differences in free recall performance between PD patients and controls. These patients, however, benefited from cues as much as controls did, and total recall did not differ between groups. When analyzing the ISDA indices for encoding, consolidation, and retrieval deficits, the results showed a general memory deficit, but with a clear focus on encoding and retrieval, as revealed by the sensitivity values. Moreover, controlling for initial learning did not eliminate group effects in retrieval. Conclusions: Our findings reveal a mixed pattern in PD patients, with deficits in both encoding and retrieval processes in memory. Also, despite the fact that an encoding dysfunction may explain some of the deficits observed at retrieval, it cannot fully account for the differences, highlighting that both encoding and retrieval factors are necessary to understand memory deficits in PD.

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“…Future studies should thus consider sampling similar populations with balanced proportions of male and female participants. Second, our population was mainly defined on the basis of scores obtained in the FCSRT for which a low performance can be related to various neurodegenerative diseases associated to pathological aging such as AD, frontotemporal dementia or Lewy body disease ( Bertoux et al, 2014 ; Lemos et al, 2015 ; Bussè et al, 2018 ). For example, despite the very high sensitivity of FCSRT (e.g., 100% in Teichmann et al, 2017 ) for identifying typical AD patients, abnormal scores in FCSRT do not have an absolute specificity (e.g., 75% in Teichmann et al, 2017 ) for typical AD.…”

Section: Discussionmentioning

confidence: 99%

Decreased Alpha Peak Frequency Is Linked to Episodic Memory Impairment in Pathological Aging

Puttaert

Wens

Fery

et al. 2021

Front. Aging Neurosci.

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The Free and Cued Selective Reminding Test (FCSRT) is a largely validated neuropsychological test for the identification of amnestic syndrome from the early stage of Alzheimer’s disease (AD). Previous electrophysiological data suggested a slowing down of the alpha rhythm in the AD-continuum as well as a key role of this rhythmic brain activity for episodic memory processes. This study therefore investigates the link between alpha brain activity and alterations in episodic memory as assessed by the FCSRT. For that purpose, 37 patients with altered FCSRT performance underwent a comprehensive neuropsychological assessment, supplemented by 18F-fluorodeoxyglucose positron emission tomography/structural magnetic resonance imaging (18FDG-PET/MR), and 10 min of resting-state magnetoencephalography (MEG). The individual alpha peak frequency (APF) in MEG resting-state data was positively correlated with patients’ encoding efficiency as well as with the efficacy of semantic cues in facilitating patients’ retrieval of previous stored word. The APF also correlated positively with patients’ hippocampal volume and their regional glucose consumption in the posterior cingulate cortex. Overall, this study demonstrates that alterations in the ability to learn and store new information for a relatively short-term period are related to a slowing down of alpha rhythmic activity, possibly due to altered interactions in the extended mnemonic system. As such, a decreased APF may be considered as an electrophysiological correlate of short-term episodic memory dysfunction accompanying pathological aging.

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Testing Hippocampal Memory in Prodromal Dementia with Lewy Bodies

Cited by 9 publications

References 16 publications

The Neuropsychological Profile of Mild Cognitive Impairment in Lewy Body Dementias

The Neuropsychological Profile of Mild Cognitive Impairment in Lewy Body Dementias

Episodic Memory Impairment in Parkinson’s Disease: Disentangling the Role of Encoding and Retrieval

Decreased Alpha Peak Frequency Is Linked to Episodic Memory Impairment in Pathological Aging

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