Testing for thyroid hormone disruptors, a review of non-mammalian in vivo models

Couderq, Stephan; Leemans, Michelle; Fini, Jean-Baptiste

doi:10.1016/j.mce.2020.110779

Cited by 34 publications

(14 citation statements)

References 125 publications

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“…The use of non-mammalian alternative models may be an ideal strategy to overcome the ethical concerns related to the traditional animal models in the safety assessment of NPs. To assess the hazards of engineered NPs, non-mammalian models such as [109] Caenorhabditis elegans (C. elegans) [110], Drosophila (Drosophila melanogaster) [111], African clawed frog (Xenopus laevis) [112], chicken chorioallantoic membrane (Gallus gallus) [113], and zebrafish (Danio rerio) [114] could be considered as reliable approaches to improve the reliability of assessments of the toxicity of NPs.…”

Section: Challenges Of Alternative Testing Strategymentioning

confidence: 99%

Current Strategies in Assessment of Nanotoxicity: Alternatives to In Vivo Animal Testing

Huang

Lee

Hsu

et al. 2021

IJMS

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Millions of experimental animals are widely used in the assessment of toxicological or biological effects of manufactured nanomaterials in medical technology. However, the animal consciousness has increased and become an issue for debate in recent years. Currently, the principle of the 3Rs (i.e., reduction, refinement, and replacement) is applied to ensure the more ethical application of humane animal research. In order to avoid unethical procedures, the strategy of alternatives to animal testing has been employed to overcome the drawbacks of animal experiments. This article provides current alternative strategies to replace or reduce the use of experimental animals in the assessment of nanotoxicity. The currently available alternative methods include in vitro and in silico approaches, which can be used as cost-effective approaches to meet the principle of the 3Rs. These methods are regarded as non-animal approaches and have been implemented in many countries for scientific purposes. The in vitro experiments related to nanotoxicity assays involve cell culture testing and tissue engineering, while the in silico methods refer to prediction using molecular docking, molecular dynamics simulations, and quantitative structure–activity relationship (QSAR) modeling. The commonly used novel cell-based methods and computational approaches have the potential to help minimize the use of experimental animals for nanomaterial toxicity assessments.

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Section: Challenges Of Alternative Testing Strategymentioning

confidence: 99%

Current Strategies in Assessment of Nanotoxicity: Alternatives to In Vivo Animal Testing

Huang

Lee

Hsu

et al. 2021

IJMS

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“…The development of specific chemical safety testing is required (Browne et al, 2020) with special attention to neurological development (Gilbert et al, 2020;Kortenkamp et al, 2020;O'Shaughnessy and Gilbert, 2020). Attention is also paid to break down the wall between mammalian and non-mammalian vertebrate regulatory testing (Couderq et al, 2020;Holbech et al, 2020). In addition to phenotypic or histological end-points, the use of molecular assays (transcripts, proteins or metabolites) will be more sensitive and most of all will allow detection before adverse effects occur (Fini et al, 2007;Kulkarni and Buchholz, 2013).…”

Section: Thyroid Function Disruptionmentioning

confidence: 99%

Interdependence of Thyroid and Corticosteroid Signaling in Vertebrate Developmental Transitions

2021

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Post-embryonic acute developmental processes mainly allow the transition from one life stage in a specific ecological niche to the next life stage in a different ecological niche. Metamorphosis, an emblematic type of these post-embryonic developmental processes, has occurred repeatedly and independently in various phylogenetic groups throughout metazoan evolution, such as in cnidarian, insects, molluscs, tunicates, or vertebrates. This review will focus on metamorphoses and developmental transitions in vertebrates, including typical larval metamorphosis in anuran amphibians, larval and secondary metamorphoses in teleost fishes, egg hatching in sauropsids and birth in mammals. Two neuroendocrine axes, the hypothalamic-pituitary-thyroid and the hypothalamic-pituitary-adrenal/interrenal axes, are central players in the regulation of these life transitions. The review will address the molecular and functional evolution of these axes and their interactions. Mechanisms of integration of internal and environmental cues, and activation of these neuroendocrine axes represent key questions in an “eco-evo-devo” perspective of metamorphosis. The roles played by developmental transitions in the innovation, adaptation, and plasticity of life cycles throughout vertebrates will be discussed. In the current context of global climate change and habitat destruction, the review will also address the impact of environmental factors, such as global warming and endocrine disruptors on hypothalamic-pituitary-thyroid and hypothalamic-pituitary-adrenal/interrenal axes, and regulation of developmental transitions.

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“…Behavioral assessment, regarded as a functional endpoint, is an integrative signal representing nervous system status or fitness [ 12 , 13 , 14 ]. Not only are larval zebrafish able to exhibit many different behaviors [ 15 , 16 ] but, analogous to mammalian neurodevelopment, the development of the zebrafish nervous system is guided and influenced by the interplay among brain development and endocrine systems such as the hypothalamus-pituitary-thyroid (HPT) axis [ 17 , 18 , 19 ] and the hypothalamo-pituitary-adrenal (inter-renal in zebrafish) (HPA/HPI) axis (reviewed in [ 20 ]). Moreover, zebrafish at all developmental stages metabolize toxic chemicals using pathways similar to mammals [ 21 , 22 ].…”

Section: Introductionmentioning

confidence: 99%

Developmental Neurotoxicity and Behavioral Screening in Larval Zebrafish with a Comparison to Other Published Results

Jarema

Hunter

Hill

et al. 2022

Toxics

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With the abundance of chemicals in the environment that could potentially cause neurodevelopmental deficits, there is a need for rapid testing and chemical screening assays. This study evaluated the developmental toxicity and behavioral effects of 61 chemicals in zebrafish (Danio rerio) larvae using a behavioral Light/Dark assay. Larvae (n = 16–24 per concentration) were exposed to each chemical (0.0001–120 μM) during development and locomotor activity was assessed. Approximately half of the chemicals (n = 30) did not show any gross developmental toxicity (i.e., mortality, dysmorphology or non-hatching) at the highest concentration tested. Twelve of the 31 chemicals that did elicit developmental toxicity were toxic at the highest concentration only, and thirteen chemicals were developmentally toxic at concentrations of 10 µM or lower. Eleven chemicals caused behavioral effects; four chemicals (6-aminonicotinamide, cyclophosphamide, paraquat, phenobarbital) altered behavior in the absence of developmental toxicity. In addition to screening a library of chemicals for developmental neurotoxicity, we also compared our findings with previously published results for those chemicals. Our comparison revealed a general lack of standardized reporting of experimental details, and it also helped identify some chemicals that appear to be consistent positives and negatives across multiple laboratories.

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Testing for thyroid hormone disruptors, a review of non-mammalian in vivo models

Cited by 34 publications

References 125 publications

Current Strategies in Assessment of Nanotoxicity: Alternatives to In Vivo Animal Testing

Current Strategies in Assessment of Nanotoxicity: Alternatives to In Vivo Animal Testing

Interdependence of Thyroid and Corticosteroid Signaling in Vertebrate Developmental Transitions

Developmental Neurotoxicity and Behavioral Screening in Larval Zebrafish with a Comparison to Other Published Results

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