Testing for anabolic steroids in hair from two bodybuilders

Kintz, Pascal; Cirimele, Vincent; Sachs, Hans; Jeanneau, T.; Ludes, Bertrand

doi:10.1016/s0379-0738(99)00024-9

Cited by 65 publications

(59 citation statements)

References 12 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…59 Saçta testosteron konsantrasyon bulgularının yorumlanması idrardakinin aksine zor olabilmektedir. Çünkü, testosteronun fizyolojik konsantrasyonları ile istismar eden kişiler arasında bulunan konsantrasyonunun oldukça yakın olduğu bildirilmiştir.…”

Section: Dopi̇ng Uygulamalarinin Doğrulanmasiunclassified

Incorporation of Drug and Substances in Hair

Mutlu¹,

Aşıcıoğlu²

2018

Turkiye Klinikleri J Foren Sci Leg Med

View full text Add to dashboard Cite

aç, homojen bir yapıya sahip gibi görünse de aslında oldukça karmaşık olan biyolojisi kısmen anlaşılmıştır.1 Memelilerde saç; protein (%65-95), su (%15-35), lipit (%1-9) ve minerallerden (<%1) oluşan deri eklerinden biridir. Saç şaftında korteksi çevreleyen bir kütikül bulunduğu gibi, bazı saç tiplerinde santral medullayı çevreleyen ilave bir kütikülde bulunmaktadır.2 Saç apokrin, sebase ve ter bezleriyle yakın ilişkide olan cildin A An na ah h t ta ar r K Ke e l li i m me e l le er r: : Saç; ilaç; birikim; kötüye kullanım A AB BS S T TR RA AC CT T In recent years hair has become a fundamental biological specimen, alternative to the usual samples blood and urine, for drug testing in the fields of forensic toxicology, clinical toxicology and clinical chemistry. Analytical results of drugs of abuse in hair provide useful information on chronic drug use. They are valuable to presume the history and severity of individual drug abuse and to provide supplementary information on drug use to facilitate interpretation of urine drug analysis. Hair testing has larger detection window. The sample collection is non-invasive. Another advantage of hair samples is that it can be stored at room temperature and do not need to be analyzed quickly after they are collected. Hair analysis is also used for detection of gestational drug exposure, doping control and detection of alcohol abuse. It has been reported that drugs are incorporated into hair by binding to such intracellular components as melanins, lipids, and proteins. It has been proposed that drugs and substances can enter into hair during at least 3 stages: from the blood during hair formation, from sweat and sebum, and from external environment. The aim of this review is to document and discuss the mechanisms of drug or substance accumulation in hair and its influencing factors, application of hair analysis.

show abstract

Section: Dopi̇ng Uygulamalarinin Doğrulanmasiunclassified

Incorporation of Drug and Substances in Hair

Mutlu¹,

Aşıcıoğlu²

2018

Turkiye Klinikleri J Foren Sci Leg Med

View full text Add to dashboard Cite

show abstract

“…Les travaux les plus récents ont essentiellement portés sur la caractérisation des anabolisants (15)(16)(17)(18)(19)(20)(21)(22)(23)(24), des B-adrénergiques (25-28), des dérivés de l'éphedri-ne (29) et des corticostéroïdes (30,31). Toutes les procédures font appel à la spectrométrie de masse, avec filtrage par simple ou triple quadripole, ou encore par haute résolution.…”

Section: Prélèvement Et Analyseunclassified

Quelle place pour les cheveux dans la lutte contre le dopage ?

Kintz¹

2000

Ann Toxicol Anal

View full text Add to dashboard Cite

show abstract

“…Dans le cas d'un bodybuilder de 32 ans mort d'une crise cardiaque, il a été identifié dans ses cheveux de la méthandiénone, de l'épiméthandiénone, de la 6-B-hydroxy-méthandiénone, de l'énantate de méthénolone, du décanoate de nandrolone, ainsi que différents esters de testosterone (propionate, isocaproate, phénylpropionate, énantate et décanoate) par CPG-SMHR-SM (30). Kintz et al rapportent la détection, par CPG-SM, de stanozolol, de nandrolone et de testosterone dans les cheveux de deux bodybuilders à des taux très élevés (31).…”

Section: Analyses Réalisées Pour Les Humainsunclassified