In this paper, novel carbon nanotube (CNT) based operational transconductance amplifiers (OTAs) have been designed and simulated. Three types of CNT-based OTAs have been designed at 45 nm technology node and have been compared with the conventional CMOS-based OTA. The comparative analysis of the key characteristics of all the devices has revealed that a significant improvement in performance is observed in the CNT-based OTAs, particularly in a pure CNT-OTA. In the pure CNT-OTA, DC gain has increased by 218%, slew rate has increased by 22.58%, the output resistance has increased by 55.2% and the power consumption is ∼ 193 times less in comparison to the conventional CMOS-OTA. Further, common mode rejection ratio (CMRR) and power supply rejection ratio positive (PSRR+) has increased by 31.87% and 136.3%, respectively in pure CNT-OTA. The performance of CNT-based OTAs has also been studied thoroughly by varying the number of CNTs (N), CNT pitch (S) and the diameter of CNTs (D CNT ) at 0.9 V. It has been observed that their performance can be improved further by using optimized values of CNT number; inter CNT-pitch and diameter. The stability analysis has shown that the pure CNT-OTA is highly stable. A 16.7% and 4% increase in phase and gain margins is achieved in the pure CNT-OTA in comparison to the bulk CMOS OTA. Finally, band and high pass filters have been realized by using the proposed CNT-based OTAs.