Testing Blood Donors for Non-A, Non-B Hepatitis: Irrational, Perhaps, but Inescapable

McClelland, D. B. L.; Cash, J. D.; Mitchell, R.; Urbaniak, S. J.; Brookes, E.; Whitrow, W.; Perry, Rachel

doi:10.1016/s0140-6736(87)93065-0

Cited by 8 publications

(1 citation statement)

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“…ALT elevation, unless perhaps extreme, re mains difficult to interpret, especially when limited to a single abnormal value at the time of donation. Official policies for blood banks are urgently needed [27], How ever, those which would recommend elimination of all units of blood with increased ALT level would exceed their pur pose. PTH prevention should be optimized by either more precise markers or more accurate methods of ALT inter pretation including serial, longitudinal assays.…”

Section: Resultsmentioning

confidence: 99%

An Epidemiological and Clinical Study of Transaminase Levels and Hepatitis B Antibodies in 1,100 Blood Donors

Driss¹,

Boboc²,

Zarski³

et al. 1989

Vox Sanguinis

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In order to provide epidemiological and clinical information on surrogate testing of blood donations, the respective prevalences of serum hepatitis B virus (HBV) markers and elevated transaminase levels were studied in 1,100 blood donors according to their geographic origin and socioeconomic level. The frequency of serum HBV markers varied as a function of HBV endemicity in the country of origin; however, it was inversely correlated (p<0.05) to the socioeconomic level of the donors, even in those originating from countries of low HBV endemicity. There was no association between serum HBV markers and the increased transaminase level which was observed in 48 (4.3%) donors. Twenty-five of these accepted further clinical evaluation. A diagnosis appeared probable in 12 of the 25; alcohol in 5; drugs in 6; non-A, non-B hepatitis in 1. Seven of the remaining 13 subjects were more than 25% above ideal body weight. Transaminase activities determined at the time of clinical assessment were normal in 14. In addition, serum HBV DNA was found in 5 of 247 donors, even in the absence of any usual HBV marker and/or hypertransaminasemia. This could account for the few cases of B and B-like posttransfusion hepatitis which are known to still occur despite careful HBsAg screening of blood donors.

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Section: Resultsmentioning

confidence: 99%

An Epidemiological and Clinical Study of Transaminase Levels and Hepatitis B Antibodies in 1,100 Blood Donors

Driss¹,

Boboc²,

Zarski³

et al. 1989

Vox Sanguinis

View full text Add to dashboard Cite

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Incidence and significance of hepatitis B core antibody in a healthy blood donor population

Kitchen

Harrison

Meacock

et al. 1988

Journal of Medical Virology

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To determine the current incidence of hepatitis B core antibody (anti-HBc) in a healthy blood donor population, 1,893 donors were screened for anti-HBc. Forty-one (2.16%) were found to be initially positive and 35 (1.85%) repeatably positive. Sera from the repeatably positive donors were further screened for hepatitis B surface antibody (anti-HBs), and hepatitis B virus DNA (HBV DNA) by dot hybridisation. The repeatably positive donors were subsequently recalled for further investigation, and their peripheral blood lymphocytes were also screened for HBV DNA by dot hybridisation. Eighteen (51.4%) of the anti-HBc-positive donors were also anti-HBs-positive. HBV DNA was not detected in the serum or the lymphocytes of any of the anti-HBc-positive donors.

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Hepatitis transmission by blood products

Yap

1988

Journal of Hospital Infection

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Testing Blood Donors for Non-A, Non-B Hepatitis: Irrational, Perhaps, but Inescapable

Cited by 8 publications

References 0 publications

An Epidemiological and Clinical Study of Transaminase Levels and Hepatitis B Antibodies in 1,100 Blood Donors

An Epidemiological and Clinical Study of Transaminase Levels and Hepatitis B Antibodies in 1,100 Blood Donors

Incidence and significance of hepatitis B core antibody in a healthy blood donor population

Hepatitis transmission by blood products

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