Testing an Intervention for Preventing Osteoporosis in Postmenopausal Breast Cancer Survivors

Waltman, Nancy; Twiss, Janice J.; C, Ott; Gross, Gloria J.; Lindsey, Ada M.; Moore, Timothy E.; Berg, Kris

doi:10.1111/j.1547-5069.2003.00333.x

Cited by 47 publications

(52 citation statements)

References 29 publications

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“…22,[42][43][44][45][46] One study examining the effects of resistance exercise in preventing skeletal muscle atrophy of bone marrow transplant recipients receiving total parenteral nutrition found that exercise induced a muscle protein-sparing effect. 22 Study results may have been confounded by variations in baseline arm muscle area and nutrition protocols.…”

Section: Resistance Exercisementioning

confidence: 99%

“…Waltman et al 46 tested a 12-month multicomponent intervention for preventing or treating osteoporosis in 21 postmenopausal breast cancer survivors. The intervention consisted of home-based strength and weight training exercises, 5 or 10 mg alendronate per day, 1500 mg calcium per day, 400 IU vitamin D per day, education on osteoporosis, and facilitative strategies to promote adherence to the intervention.…”

Section: Resistance Exercisementioning

confidence: 99%

“…Resistance exercise appears not to induce or worsen lymphedema associated with surgical dissection of lymph nodes. 46 As such, resistance exercise needs further exploration as a means of increasing muscle strength and assisting with the development of lean body mass for women with breast cancer.…”

Section: Resistance Exercisementioning

confidence: 99%

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Muscle Strength, Body Composition, and Physical Activity in Women Receiving Chemotherapy for Breast Cancer

Visovsky

2006

Integr Cancer Ther

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There is evidence to suggest that treatment of breast cancer with chemotherapy can induce metabolic changes in skeletal muscle. Women undergoing treatment for breast cancer with certain chemotherapeutic agents can experience declines in lean body mass and muscle strength and a subsequent increase in body weight. These alterations not only can lead to declines in physical function but also predispose women to weight-related chronic illness. Excess body weight may also play a role in the development or recurrence of breast cancer. There is evidence that physical exercise may improve body composition and enhance muscular endurance, flexibility, and quality of life (QOL) in women with breast cancer. While studies of aerobic, resistance, and combinations of aerobic and resistance exercise for women with breast cancer have been conducted, most studies employed supervised aerobic exercise sessions. Few studies have examined the role of resistance exercise or the combination of resistance and aerobic exercise in maintaining or increasing muscle strength while preserving lean body mass in this population. The relatively small sample sizes and short duration of physical activity interventions in previous studies make it difficult to detect dose responses to exercise training. Physical activity interventions with larger sample sizes and of longer duration are necessary to achieve longterm health outcomes. Physical activity interventions that include the older or more obese women with breast cancer are also needed, as this population may be most at risk of functional decline and the development of chronic illness. Interventions appropriate for women treated for breast cancer who have comorbid disease are also needed. Newer, more intense chemotherapy regimens may induce a differential effect on muscle strength and body composition. However, the role of physical activity during dose-dense chemotherapy protocols has not been established. Keywords: breast cancer; muscle strength; body composition; physical activityThe role of exercise and physical activity in cancer prevention, recovery, and rehabilitation has been the focus of much recent literature. In terms of cancer prevention, physical activity and exercise have been touted as part of a healthy lifestyle that can reduce the incidence of obesity-related chronic illnesses, cancer, and cancer recurrence. However, the mechanism by which physical activity or exercise exerts its effect and the amount of activity necessary remains unknown. There is evidence that physical exercise may improve body composition and enhance muscular endurance, flexibility, and quality of life (QOL) in women with breast cancer. However, most studies of exercise and cancer survivorship have been limited by small sample sizes, similar cancer disease stages, the use of single-modality exercise regimens, and limited duration of follow-up. Investigations of breast cancer disease and treatment side effects on muscle strength and body composition have been limited. The purpose of this article is to examine t...

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Section: Resistance Exercisementioning

confidence: 99%

Section: Resistance Exercisementioning

confidence: 99%

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Muscle Strength, Body Composition, and Physical Activity in Women Receiving Chemotherapy for Breast Cancer

Visovsky

2006

Integr Cancer Ther

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“…1). Of the 36 full papers reviewed, 25 were excluded because no bone outcome was included in the trial, leaving 11 papers that met our inclusion criteria [23][24][25][26][27][28][29][30][31][32][33]. Two trials that reported BMD assessment in the methods were excluded because BMD results were not reported [32,33].…”

Section: Resultsmentioning

confidence: 99%

A review of exercise interventions to improve bone health in adult cancer survivors

2010

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“…More than 70 controlled trials have examined exercise in breast cancer patients and survivors; however, only seven have examined bone health outcomes [71][72][73][74][75][76][77]. Studies assessing bone health in breast cancer patients have typically included women who are peri-or postmenopausal [71][72][73][74][75][76]78], are at least 6 months post primary chemotherapy or radiation therapy [71,72,[75][76][77] and receiving adjuvant selective estrogen receptor modulators or aromatase inhibitors [71][72][73][74][75][76][77]. Three RCTs showed that exercise may prevent the typical loss of BMD experienced in patients that are not exercising [71,77,78].…”

Section: Exercise and Cancer-related Bone Loss In Women With Breast Cmentioning

confidence: 99%

Physical Exercise for Secondary Osteoporosis

Mina

Alibhai²,

Matthew³

et al. 2012

TOBONEJ

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Bone loss caused by an underlying medical illness or associated treatment is often termed secondary osteoporosis and is a growing concern for a variety of patients. Exercise has demonstrated efficacy in maintaining bone health for individuals with age-related osteoporosis and its application to other clinical populations with specific interest in preserving bones is being increasingly explored. While there are many causes of secondary osteoporosis, only a few clinical populations have been studied for the role of exercise as a non-pharmacologic approach to bone preservation. This article briefly reviews secondary osteoporosis and the effect of exercise on bone health, while highlighting the current exercise intervention literature on bone outcomes for several clinical populations.

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Testing an Intervention for Preventing Osteoporosis in Postmenopausal Breast Cancer Survivors

Cited by 47 publications

References 29 publications

Muscle Strength, Body Composition, and Physical Activity in Women Receiving Chemotherapy for Breast Cancer

Muscle Strength, Body Composition, and Physical Activity in Women Receiving Chemotherapy for Breast Cancer

A review of exercise interventions to improve bone health in adult cancer survivors

Physical Exercise for Secondary Osteoporosis

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