Testikulärer Keimzelltumor und Sarkoidose

May, Marc-Antoine; Gunia, Sven; Siegsmund, M.; Kaufmann, O.; Helke, C.; Hoschke, B.; Wille, Andreas

doi:10.1007/s00120-006-1052-4

Cited by 6 publications

(3 citation statements)

References 12 publications

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“…[74] Rayson et al . [75] reported that the sarcoidosis incidence among patients with testicular cancer was >6/10,000 or approximately 100 times the baseline incidence expected for young white males.…”

Section: Scrotum Testicular and Paratesticular Structuresmentioning

confidence: 99%

Genitourinary sarcoidosis: An essential review for the practicing clinician

Block

Kava

2017

Indian J Urol

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Introduction:Sarcoidosis is a multisystem disease that commonly involves the lungs, but may also present with extrapulmonary manifestations. Genitourinary (GU) tract involvement has been traditionally thought to be rare, but that view may underestimate the true prevalence of the disease due to the often, silent presentation thereof.Methods:The literature pertaining to sarcoidosis from the general systemic point of view, etiology and therapy and with regard to specific organs was reviewed by identifying key words in a PubMed search. That material with special relevance to the Indian experience was emphasized.Results:There are a number of isolated case reports in the literature describing symptomatic and asymptomatic GU tract sarcoidosis. The world literature associated with the generalized syndrome was reviewed and summarized. Specific aspects of GU involvement are presented for each organ of the GU tract.Conclusions:It is critical for the practicing clinician to have a working knowledge of the clinical manifestations of this disease as it involves the GU tract, as well as to be able to distinguish it from tuberculosis and the various malignancies that affect this organ system.

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Section: Scrotum Testicular and Paratesticular Structuresmentioning

confidence: 99%

Genitourinary sarcoidosis: An essential review for the practicing clinician

Block

Kava

2017

Indian J Urol

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“…When we search through the sarcoidosis-malignancy association in the literature, sarcoidosis plays the most frequent association with HL among haematopoietic malignancies and with germ cell tumours among non-haematopoietic malignancies [5,6]. This predilection endows a critical role to specific tumour antigens in the pathogenesis of sarcoidosis, suggesting that HL and seminoma antigens are more 'sarcoidogenic' than others.…”

Section: Discussionmentioning

confidence: 99%

Sarcoidosis mimicking lymphoma on positron emission tomography-computed tomography in two patients treated for lymphoma: two case reports

Ozer¹,

Eşkazan

et al. 2009

J Med Case Rep

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IntroductionSarcoidosis is a granulomatous disease that mostly involves the lungs. Its association with malignancies has been well documented. Several mechanisms have been proposed that may underlie this concurrence including triggering tumour antigens and defective cellular immunity.Case presentationsWe briefly review the literature on malignancy associated sarcoidosis and report two female lymphoma patients of 49 and 56 years of age who, during their course of disease, developed sarcoidosis that was misinterpreted as a lymphoma relapse on positron emission tomography-computed tomography.ConclusionWe hypothesise that T cell dysfunction and exposure to tumour associated antigens might be the underlying mechanisms of development of sarcoidosis in patients with lymphoma. Positron emission tomography-positive lesions do not always indicate malignancy and therefore a tissue biopsy is always mandatory to confirm the diagnosis.

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“…Later on, in 1986 Brinker described the sarcoidlymphoma syndrome, which is defined as a lymphoma appearing at least 1 or 2 years after a diagnosis of sarcoidosis [3]. Then, he studied more specifically the association between granulomatous reactions and cancers [2].It seems that these reactions are found in 5% of neoplastic diseases [4], and the association is particularly strong with germinal testicular cancer [5], Hodgkin disease and certain T-cell lymphomas [6].…”

Section: Introductionmentioning

confidence: 99%

Systemic Granulomatosis in the Context of Solid Tumors: A Study of 10 Cases

Fares

Benzakour

Al-Azhari

et al. 2022

JCTI

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Introduction: The association between solid cancers and sarcoidosis is well-known, however,we shouldn’t quickly link a granulomatous lesion to sarcoidosis in a patient suffering from a solid tumor, hence, a granuloma in the context of a solid cancer presents a diagnostic and a therapeutic challenge. Methods: It’s a retrospective monocentric study of 10 cases, suffering from solid tumors, with granulomatous lesions. The type of cancer, the temporal relation between the granulomatous lesion and the cancer, the associated symptoms, the final diagnosis and the disease progression are reported. The patients were separated into three sub groups based on the time of appearance of the granulomatous lesions in relation to the solid tumor. Results: Discovery of granulomatous lesions preceded the diagnosis of cancer in 1 case, discovered concomitantly with cancer in 5 cases and finally after the cancer in 4 cases. The main solid cancer in our study was breast invasive ductal carcinoma (40%), the other cancers were: squamous cell carcinoma of the breast, colorectal adenocarcinoma, ovarian epithelial cancer, esophageal squamous cell carcinoma, thyroid papillary carcinoma and uterine sarcoma. Conclusion: A granuloma in the course of solid cancers maybe associated with multiple etiologies. Therefore, the clinician may face many difficulties, ranging from failing to diagnose a cancer to a wrong conclusion of treatment failure or a relapse. The biopsy is still the only guiding element.

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Testikulärer Keimzelltumor und Sarkoidose

Cited by 6 publications

References 12 publications

Genitourinary sarcoidosis: An essential review for the practicing clinician

Genitourinary sarcoidosis: An essential review for the practicing clinician

Sarcoidosis mimicking lymphoma on positron emission tomography-computed tomography in two patients treated for lymphoma: two case reports

Systemic Granulomatosis in the Context of Solid Tumors: A Study of 10 Cases

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