Testicular vein thrombosis: Incidence of recurrent venous thromboembolism and survival

Abstract

Purpose: Testicular vein thrombosis (TVT) etiology, recurrence, and survival were compared with lower extremity deep vein thrombosis (DVT) in order to determine whether treatment guidelines for DVT could be applied to TVT. Patients and Methods:An inception cohort of patients with confirmed TVT (January 1995-October 2015) was compared to a control group of patients with lower extremity DVT matched by age, gender, and diagnosis date.Results: Thirty-nine men with TVT were identified; 15 (38%) with isolated TVT. Left testicular vein was affected in 77% patients; there were no cases of bilateral TVT.Cancer was over twofold more common in TVT patients (59% vs 28%, P = .01). Most cancers (78%) involved organs in proximity to the testicular vein. Although TVT patients were less frequently treated with anticoagulants (49% vs 97%, P = .0001), recurrence rates were similar to DVT group (TVT 4.2 vs DVT 1.1 per 100 patient-years, P = .11). Despite higher cancer prevalence, survival rates were similar between groups (31% vs 28%; P = .34). Major bleeding events were rare (one patient per group). Conclusions:Identifying TVT should prompt a search for a regional malignancy.Despite the high cancer prevalence and low utilization of anticoagulants, recurrent venous thrombosis and mortality rates are similar to DVT patients.

Trombosis de la vena espermática derecha. Primer caso clínico reportado en Colombia

“…Nonetheless, clinical conditions associated with the presentation of this disorder have been described, leading to the development of different theories about its possible origin. Authors such as Esmon (6), Grainge et al Other risk factors for venous thromboembolism such as cancer, hospitalization, recent surgeries, infections, trauma, inflammatory diseases and personal or family history of venous thromboembolism may also influence the development of SVT (11). In the reported case, it is suspected that the thrombus formed as a result of an inflammatory process in the ductus deferens; however, the cause of the deferentitis observed in the ultrasound is unknown.…”

“…In addition, it is important to note that the anatomical connection between the testicular vein and the left renal vein allows kidney disorders, including neoplasms, to spread to the left spermatic vein and cause thrombosis. SVT has also been linked to renal, testicular, adrenal, gastrointestinal, hematologic, and liposarcoma cancers in that order of occurrence (11,17).…”

Testicular vein thrombosis mimicking epididymo-orchitis after suspected Covid-19 infection

“…Interestingly, a study by Lenz and colleagues 1 comparing a series of 39 patients in their institution with reported testicular vein thrombosis between 1995 and 2015 with a selection of patients with deep vein thrombosis (DVT) reported 59% were associated with malignancy. However, in many of these cases, the testicular vein thrombosis was found as an incidental finding during staging of the malignancy, and once in the follow-up of an abdominal aortic aneurysm, and the thrombosis was not the presenting problem.…”

Thrombosis of atypical location: how to treat patients in the era of direct oral anticoagulants?

“…Gonadal vein thrombosis Gonadal vein thrombosis (GVT) consists of 2 sex -dependent diagnoses: ovarian vein thrombosis in women 6 and testicular vein thrombosis in men. 7 GVT is associated with a high prevalence of cancer (over twice as frequent compared with control groups with leg DVT). GVT has also shown similar VTE recurrence and major bleeding rates compared with leg DVT.…”

“…Current clinical practice is that patients with acute GVT are treated with anticoagulation for 3 to 6 months. 6,7,28,29 Information about the use of DOACs for GVT is limited to a few case reports. 27,30 It continues to be the practice of Mayo Thrombophilia Clinic to provide anticoagulant therapy that includes also DO-ACs to patients with GVT in the absence of a direct contraindication, such as major bleeding.…”