Testicular tumors in undescended testes

Omar, Sherif; Eissa, Saad; Elsaid, Ahmed; Mebed, Hassan; Elbadawi, Salah

doi:10.3109/01485017908985050

Cited by 5 publications

(3 citation statements)

References 6 publications

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“…46 As well, BM's defect could result in altered parameters of the seminiferous tubules and widening of the intertubular spaces. 47 Interestingly, the present data revealed a significant correlation between the spermatogenic score count and the measured thickness of the PS in the control as well as the experimental groups. This supported our suggestion that the deteriorating effect of ribavirin on the structure and function of the seminiferous tubules could exist through the impairment of the components of the peritubular tissues, namely, BM, myoid cells, and ECM.…”

Section: Discussionsupporting

confidence: 51%

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Structural evaluation of the peritubular sheath of rat’s testes after administration of ribavirin: A possible impact on the testicular function

Almasry

Hassan

Elsaed

et al. 2017

Int J Immunopathol Pharmacol

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Effects of ribavirin on the structure of peritubular sheath (PS) of seminiferous tubules and on testicular functions were studied. We found that ribavirin at a dose of 4 mg/kg/day for 4 weeks produced a significant reduction in testosterone level (6.3 ± 0.2; P < 0.001) and in spermatogenic score count (3.8 ± 0.2; P < 0.001) compared to control values. The thickness of PS (17.8 ± 1.13) and tubular lumen perimeter (1024.7 ± 67) was significantly increased compared to controls (10.7 ± 0.70; P < 0.001 and 808 ± 25; P = 0.004, respectively). The length of germinal epithelium (411.8 ± 39) and tubular external diameters (1661.8 ± 115) was significantly reduced compared to control values (708.4 ± 40; P < 0.001 and 2358.8 ± 169; P < 0.001, respectively). The basement membranes (BMs) were thickened with great deposition of collagen. Myoid cells showed altered structure and extracellular matrix revealed disorganization by excessive collagen I and IV accumulation. Testicular damage was established histologically. Evidence of apoptosis was detected in germ cells. There was a significant increase in integrated density of Casp-3 expression (38,121,743 ± 1,763,420; P < 0.001) in seminiferous tubules compared to control (24,788,409 ± 1,900,140). It is concluded that ribavirin can cause alterations of the testicular function and structure with increased apoptosis in the tissues after 4 weeks of administration. The damaging effect could be persuaded by destruction of the peritubular sheath.

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Section: Discussionsupporting

confidence: 51%

“… 46 As well, BM’s defect could result in altered parameters of the seminiferous tubules and widening of the intertubular spaces. 47 …”

Section: Discussionmentioning

confidence: 99%

Structural evaluation of the peritubular sheath of rat’s testes after administration of ribavirin: A possible impact on the testicular function

Almasry

Hassan

Elsaed

et al. 2017

Int J Immunopathol Pharmacol

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“…One of these patients had enlarged inguinal lymph nodes and had a left orchiectomy, hemiscrotectomy, and inguinal block dissection performed in addition to his RBD. Two patients had tumors in undescended testes (reported previously [7]) and orchiectomy was performed transabdominally. The other ten cases were diagnosed on high radical orchiectomy .…”

Section: Methodsmentioning

confidence: 99%

Retroperitoneal Block Dissection in the Treatment of Nonseminomatous Tumors of the Testis

Omar

Eissa

Nasser

et al. 1980

Archives of Andrology

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Fifteen patients with nonseminomatous tumors of the testis, stages I and II, underwent a retroperitoneal block dissection as part of their treatment regimen. Nonseminomatous germ cell and paratesticular tumours were reported. The preoperative measures and operative technique of the anterior transabdominal approach are described. There were no deaths or major postoperative complications encountered, in spite of the magnitude of the surgery involved. In two patients the tumor had occurred in an undescended testis. No patient had normal ejaculatory function after the operation. Special attention is drawn to the proper management of patients having undergone a transscrotal biopsy or orchiectomy. Five patients with a relatively long-term follow-up, are free of disease and doing well.

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Clinical Disparities for Minorities and Foreign-Born Men With Undescended Versus Descended Testicular Germ Cell Tumors

Klaassen

Reinstatler

Wilson

et al. 2016

Clinical Genitourinary Cancer

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Testicular tumors in undescended testes

Cited by 5 publications

References 6 publications

Structural evaluation of the peritubular sheath of rat’s testes after administration of ribavirin: A possible impact on the testicular function

Structural evaluation of the peritubular sheath of rat’s testes after administration of ribavirin: A possible impact on the testicular function

Retroperitoneal Block Dissection in the Treatment of Nonseminomatous Tumors of the Testis

Clinical Disparities for Minorities and Foreign-Born Men With Undescended Versus Descended Testicular Germ Cell Tumors

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