Testicular Tumor Pathology

Wojno, Kirk J.; Bégin, Louis R.

doi:10.1007/978-1-4419-0449-2_4

Cited by 2 publications

(1 citation statement)

References 26 publications

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“…After initial chemotherapy in patients with mixed TGCT with a portion of teratoma, teratoma can be found in the residual mass in 82% of cases . CC metastasises early, therefore a high percentage of mixed tumours show a poor prognosis . For several years, different studies found an amount of >50% EC to confer a higher risk for relapses .…”

Section: Discussionmentioning

confidence: 99%

HMGA2 expression distinguishes between different types of postpubertal testicular germ cell tumour

Kloth

Gottlieb

Helmke

et al. 2015

The Journal of Pathology CR

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The group of postpubertal testicular germ cell tumours encompasses lesions with highly diverse differentiation – seminomas, embryonal carcinomas, yolk sac tumours, teratomas and choriocarcinomas. Heterogeneous differentiation is often present within individual tumours and the correct identification of the components is of clinical relevance. HMGA2 re‐expression has been reported in many tumours, including testicular germ cell tumours. This is the first study investigating HMGA2 expression in a representative group of testicular germ cell tumours with the highly sensitive method of quantitative real‐time PCR as well as with immunohistochemistry. The expression of HMGA2 and HPRT was measured using quantitative real‐time PCR in 59 postpubertal testicular germ cell tumours. Thirty specimens contained only one type of tumour and 29 were mixed neoplasms. With the exception of choriocarcinomas, at least two pure specimens from each subgroup of testicular germ cell tumour were included. In order to validate the quantitative real‐time PCR data and gather information about the localisation of the protein, additional immunohistochemical analysis with an antibody specific for HMGA2 was performed in 23 cases. Expression of HMGA2 in testicular germ cell tumours depended on the histological differentiation. Seminomas and embryonal carcinomas showed no or very little expression, whereas yolk sac tumours strongly expressed HMGA2 at the transcriptome as well as the protein level. In teratomas, the expression varied and in choriocarcinomas the expression was moderate. In part, these results contradict data from previous studies but HMGA2 seems to represent a novel marker to assist pathological subtyping of testicular germ cell tumours. The results indicate a critical role in yolk sac tumours and some forms of teratoma.

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Section: Discussionmentioning

confidence: 99%

HMGA2 expression distinguishes between different types of postpubertal testicular germ cell tumour

Kloth

Gottlieb

Helmke

et al. 2015

The Journal of Pathology CR

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Seminoma Anaplastik Dengan Yolk Sac Tumor Testis (Mixed Germ Cell Tumor Testis)

Loho

2013

JBM

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Testicular cancer is relatively rare, accounting for less than 1% of malignant tumors affecting men. More than 90% of these tumors are of germ cell origin and most of them are found in young men between the ages of 15-34 years. Germ cell tumors are divided into seminoma and nonseminoma tumors. The seminoma makes up 30-40% of all testicular tumors. An anaplastic seminoma is a classic type of seminoma that has three or more mitosis under the high power microscopic field, combined with other morphologic criteria such as nuclear hyperchromasia, greater nucleolar sizes, pleomorphism, and an amount of necrosis. We reported a case of a 38-year-old male that was clinically diagnosed with a left testicular tumor and with an elevated alpha fetoprotein (AFP) and β human chorionic gonadotropin (β HCG) serum. The histopathological diagnosis was an anaplastic seminoma with a yolk sac tumor (YCT), i.e. a mixed germ cell tumor. Keywords: seminoma, testicular tumor, yolk sac tumor. Abstrak: Kanker testis relatif jarang, <1% dari semua kanker ganas pada laki-laki. Lebih dari 90 persen jenis tumor ini berasal dari sel germinal dan umumnya menyerang laki-laki muda berusia 15-34 tahun. Tumor sel germinal dibagi atas dua jenis: seminoma dan non seminoma. Jenis seminoma terdapat pada 30-40% dari seluruh tumor testis. Seminoma anaplastik adalah seminoma dengan ciri klasik mikroskopik berupa adanya tiga atau lebih sel-sel mitosis per lapangan pandang besar, disertai terdapatnya kriteria morfologik lain seperti inti sel hiperkromatik, anak inti berukuran besar, pleomorfik, dan terdapatnya sejumlah nekrosis. Kami melaporkan kasus seorang laki-laki berusia 38 tahun dengan diagnosis klinis tumor testis kiri disertai peningkatan kadar alfa feto protein (AFP) dan β human chorionic gonadotropin (β HCG) serum. Diagnosis histopatologik ialah seminoma anaplastik dengan tumor yolk sac (YCT), yaitu tumor sel germinal campuran. Kata kunci: seminoma, tumor testis, tumor yolk sac.

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Testicular Tumor Pathology

Cited by 2 publications

References 26 publications

HMGA2 expression distinguishes between different types of postpubertal testicular germ cell tumour

HMGA2 expression distinguishes between different types of postpubertal testicular germ cell tumour

Seminoma Anaplastik Dengan Yolk Sac Tumor Testis (Mixed Germ Cell Tumor Testis)

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