Testicular structure and sperm production in flounders from a polluted estuary: a preliminary study

Gill, M.E.; Spiropoulos, John; Moss, C

doi:10.1016/s0022-0981(02)00396-9

Cited by 19 publications

(13 citation statements)

References 16 publications

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“…Bearing in mind that in no case is there necessarily a causal link, high plasma concentration of VTG in flounder have so far been associated with higher incidences of testicular malformation (Gill et al 2002; Lye et al 1997, 1998), higher amounts of oocyte malformation (Lye et al 1998), more sperm abnormalities (Gill et al 2002), more pathological lesions in the liver and kidney (Simpson et al 2000), higher sperm motility (Kleinkauf et al 2004b), lower gonadosomatic index (Kleinkauf et al 2004a), and lower sex steroid concentrations (this study). However, there has been no clear link with degree of intersex (Allen et al 1999a; Kirby et al 2004a; Simpson et al 2000), estrogen receptor concentrations in the liver (Kleinkauf et al 2004b), hepatocyte proliferation markers (Kleinkauf et al 2004b), ethoxyresorufin O -deethylase induction (Kirby et al 2004b), or even with VTG mRNA (Craft et al 2004; George et al 2004).…”

Section: Discussionmentioning

confidence: 99%

“…The closest we can get to answering the question about population effects in flounder is to examine whether overtly important reproductive parameters, such as fecundity and fertility, are related to the presence of EDCs in estuaries. Few such studies have been carried out in the rivers Tyne, Dee, and Mersey in the United Kingdom (Gill et al 2002; Kleinkauf et al 2004a, 2004b; Lye et al 1997, 1998; Simpson et al 2000). They all show that flounder from contaminated estuaries (i.e., where fish have consistently high VTG concentrations) also exhibit more signs of disrupted gonadal development (listed in “Discussion”) than flounder from uncontaminated estuaries.…”

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confidence: 99%

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Relationship between Sex Steroid and Vitellogenin Concentrations in Flounder ( Platichthys flesus ) Sampled from an Estuary Contaminated with Estrogenic Endocrine-Disrupting Compounds

Scott

Katsiadaki

Kirby

et al. 2006

Environ Health Perspect

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High concentrations of vitellogenin (VTG; egg yolk protein) have previously been found in male flounder (Platichthys flesus) from several UK estuaries; these levels have been ascribed to the presence of estrogenic endocrine-disrupting compounds (EDCs). Gonadal abnormalities, including intersex, have also been recorded in these estuaries. However, there is no firm evidence to date that these two findings are causally linked or that the presence of estrogenic EDCs has any adverse population effects. In the present study, we examined the relationship between concentrations of VTG and sex steroids (11-oxotestosterone in males and 17β-estradiol in females) in specimens of flounder captured from the estuary of the River Mersey. We first questioned whether the high concentrations of VTG in male and immature female flounder were indeed caused by a direct effect of exogenous EDCs and not indirectly via the endogenous secretion of 17β-estradiol. The data favored the direct involvement of estrogenic EDCs. We then questioned whether the presence of estrogenic EDCs not only stimulated inappropriate VTG synthesis but whether it might also have had a negative effect on endogenous steroid secretion. It should be noted that the predicted consequences of a drop in steroid secretion include smaller gonads, smaller oocytes, fewer numbers of sperm, and depressed spawning behavior. This question was more difficult to answer because of the strong effect of the seasonal reproductive cycle and stage of maturation on steroid concentrations. However, matched by month of capture and stage of maturation, both 17β-estradiol in females and 11-keto-testosterone in males were in most cases significantly lower in those years when VTG concentrations were higher.

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Section: Discussionmentioning

confidence: 99%

mentioning

confidence: 99%

Relationship between Sex Steroid and Vitellogenin Concentrations in Flounder ( Platichthys flesus ) Sampled from an Estuary Contaminated with Estrogenic Endocrine-Disrupting Compounds

Scott

Katsiadaki

Kirby

et al. 2006

Environ Health Perspect

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“…Abnormal production of VTG by male and immature fishes has been used as a bioindication of xenoestrogenic impact [3,4]. For example, total or partial feminisation, or demasculinisation have been described in different studies [5][6][7][8][9][10][11][12]. Male and immature fishes possess the VTG gene, but normally do not synthesise enough estrogen to induce its expression [4].…”

Section: Introductionmentioning

confidence: 99%

One-step, non-denaturing purification method of carp (Cyprinus carpio) vitellogenin

Magalhães

Ledrich

Pihan

et al. 2004

Journal of Chromatography B

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“…These contaminants act as xenoestrogens, causing feminization in male fish, or rather a decrease in their reproductive functionality, including changes in motility, morphology and fertility (Kime & Nash, 1999;Gill et al, 2002;Jobling et al, 2002). These contaminants act as xenoestrogens, causing feminization in male fish, or rather a decrease in their reproductive functionality, including changes in motility, morphology and fertility (Kime & Nash, 1999;Gill et al, 2002;Jobling et al, 2002).…”

Section: Contamination With Exogenous Hormonesmentioning

confidence: 99%

Gamete quality in fish: evaluation parameters and determining factors

Valdebenito

Gallegos

Effer

2013

Zygote

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The quality of fish gametes, both male and female, are determined by several factors (age, management, feeding, chemical and physical factors, water quality, etc.) that have an impact on the survivability of embryos, larvae and/or fry in the short or long term. One of the most important factors is gamete ageing, especially for those species that are unable to spawn naturally in hatcheries. The chemical and physical factors in hatcheries and the nutrition that they provide can significantly alter harvest quality, especially from females; as a rule, males are more tolerant of stress conditions produced by inadequate feeding, management and/or poor water conditions. The stress produced on broodstock by inadequate conditions in hatcheries can produce adverse effects on gamete quality, survival rates, and the embryonic eggs after hatching.

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Testicular structure and sperm production in flounders from a polluted estuary: a preliminary study

Cited by 19 publications

References 16 publications

Relationship between Sex Steroid and Vitellogenin Concentrations in Flounder ( Platichthys flesus ) Sampled from an Estuary Contaminated with Estrogenic Endocrine-Disrupting Compounds

Relationship between Sex Steroid and Vitellogenin Concentrations in Flounder ( Platichthys flesus ) Sampled from an Estuary Contaminated with Estrogenic Endocrine-Disrupting Compounds

One-step, non-denaturing purification method of carp (Cyprinus carpio) vitellogenin

Gamete quality in fish: evaluation parameters and determining factors

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