Testicular sperm extraction (TESE) and ICSI in patients with permanent azoospermia after chemotherapy

Meseguer, Marcos; Garrido, Nicolás; Remohı́, José; Pellicer, A.; Simón, Carlos; Martínez-Jabaloyas, José María; Gil-Salom, Manuel

doi:10.1093/humrep/deg260

Cited by 147 publications

(83 citation statements)

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“…There are many studies investigating SRR and results of ICSI in patients with NOA (Kahraman et al, 1996b;Meseguer et al, 2003). Parameters affecting spermatozoa retrieval and success of surgical technique have also been examined (Turunc et al, 2010;Ghalayini et al, 2011).…”

Section: Discussionmentioning

confidence: 99%

Sperm retrieval and live birth rates in presumed Sertoli‐cell‐only syndrome in testis biopsy: a single centre experience

et al. 2012

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SUMMARYWe aimed to investigate sperm retrieval rates (SRR) by testicular sperm extraction (TESE), factors affecting SRR, and fertilization rate (FR), implantation rate (IR), clinical pregnancy rate (CPR) and live birth rate (LBR) in patients with presumed Sertoli-cell-only syndrome in testis biopsy (SCOS). We retrospectively evaluated files of 134 patients with SCOS who underwent TESE. Group I were patients in whom spermatozoa were retrieved and Group II were patients in whom no spermatozoa could be retrieved. SRR, Follicle stimulating hormone (FSH), Luteinizing hormone (LH), and testosterone levels, and the volume of testicles were compared between groups. In addition, FR, IR, CPR and LBR were determined. Sperm retrieval was achieved in 37 (27.6%) patients (Group I), and the remaining 97 (72.4%) patients made Group II. There were no significant differences in age, infertility time, testicular volume, serum FSH, LH and testosterone levels between Groups I and II (p > 0.05). Intracytoplasmic sperm injection (ICSI) was performed in 36 patients. FR, IR, and CPR were 60.86 ± 23.03, 36.53 ± 41.78 and 51.3% respectively. Cycle and patient based LBRs were 37.8 and 45.1% respectively. SRR in SCOS is lower than patients with non-obstructive azoospermia (NOA) in general. No parameters to predict spermatozoa retrieval were determined. In patients with SCOS, ICSI achieves similar live birth rate to other patients with NOA.

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Section: Discussionmentioning

confidence: 99%

Sperm retrieval and live birth rates in presumed Sertoli‐cell‐only syndrome in testis biopsy: a single centre experience

et al. 2012

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“…In humans and primates where spermatozoa may be isolated in testicular biopsies, it has been shown that recovery after severe damage occurs only focally in a few seminiferous tubules. Patients will be permanently infertile if tubules become fully hyalinized or a complete Sertoli cell only pattern is established (32,33). The spermatogenic stem cells are susceptible to this type of damaging insult at all ages, but the full impact on spermatogenesis manifests itself during onset of puberty (34).…”

Section: Differences In Germline Stem Cell Biology In Females and Malmentioning

confidence: 99%

“…All pubertal boys with testis volumes above 10 -12 mL are encouraged to donate a semen sample before cancer therapy (43,44). Alternatively, electro-ejaculation or testicular sperm extraction from a biopsy can be used as a source to retrieve spermatozoa for boys unable to ejaculate (33). Expediency in fertility preservation due to urgency for immediate cancer therapy poses a unique issue in these young patients (see discussion on ethical aspects below).…”

Section: Cryopreservation Of Gametesmentioning

confidence: 99%

Clinical Potential and Putative Risks of Fertility Preservation in Children Utilizing Gonadal Tissue or Germline Stem Cells

et al. 2006

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“…Fertilitenin geri dönebilmesi için bu hücrelerin belirli bir süre sonra yeniden A (koyu) tip hücrelerden oluşması gerekmektedir. Daha yüksek dozlarda A (koyu) spermatogonia hücreleri de hasar görüp hastada kalıcı azoospermiye ve seminifer tubuller içerisinde sadece Sertoli hücrelerinin bulunduğu yapının oluşmasına neden olabilir (26,27). Uygulanan doz dışında fertilitenin korunmasında kullanılan kemoterapötik ajan, radyasyon uygulamalarında uygulanan bölge, uygulama sıklığı da rol oynamaktadır (28).…”

Section: Radyoterapi Ve Kemoterapinin Fertilite üZerinde Etkisiunclassified

Testis Kanserli Hastalarda Sperm Dondurma ve İnfertilite

Bakircioglu¹,

Alıcı²

2014

uob

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Güncel kanser tedavileri ile genç erkeklerin yaşam süreleri uzamasına karşın kullanılan kemoterapi ve radyoterapi infertiliteye neden olabilmektedir. Bu derlemede amacımız testis kanserli erkeklerde fertilite potansiyelinin tedavi öncesinde ve sonrasında korunması hakkında literatür bilgilerini incelemektir. Testis kanserli erkeklerde sperm konsantrasyonları diğer kanser tiplerine göre daha düşük olduğu tespit edilmiştir. Tedavi için kullanılan kemoterapi ve radyoterapi spermatogenezi negatif olarak etkilemektedir. Buna rağmen kemoterapi gören erkeklerin sperm parametreleri 1 yıl sonra, radyoterapi görenlerde ise 2 yıl sonra tedavi öncesi değerlere geri dönebilir. Erkeklerde tedavi öncesinde azoospermi görüldüğü durumlarda orşiektomi ile eş zamanlı testisten sperm elde ederek (TESE) sperm saklama uygulanabilir. Sperm dondurma kanser hastalarında fertilite potansiyelinin korunması için hala altın standarttır. Bu nedenle testis kanseri teşhis edilen erkeklerin tedavilerine başlamadan önce mevcut potansiyellerinin anlaşılması ve sperm dondurma işlemi için infertilite merkezlerine başvurmaları desteklenmelidir. (Üroonkoloji Bülteni 2014;13:176-181) Anah tar Ke li me ler: Testis kanseri, sperm dondurma, infertilite Modern cancer therapies have greatly improved survival rates in men of reproductive age and younger; however, surgery, chemotherapy and radiation therapy may lead to male infertility. In this review, we would like to investigate fertility status of men with testicular cancer and sperm preservation options before and after cancer treatment. Sperm concentration of patients diagnosed with testicular cancer is lower than other cancer patients. In addition to that chemotherapy and radiotherapy negatively affect spermatogenesis. Radiotherapy have a much more deleterious effect on fertility compared with chemotherapy alone. However, after one year of chemotherapy or two years of radiotherapy, semen parameters may return to basal levels before cancer therapy. If the patient is azoospermic before any cancer specific treatment, testicular sperm extraction (TESE) for cryopreservation is an option at the time with orchiectomy operation. Sperm cryopreservation is still a gold standard to preserve fertility potential for cancer patients before the cancer specific treatments. Therefore, men diagnosed with testicular cancer should be encouraged to contact with infertility clinics to understand their fertility potentials and for sperm cryopreservation. (Bulletin of Urooncology 2014;13:176-181)

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Testicular sperm extraction (TESE) and ICSI in patients with permanent azoospermia after chemotherapy

Cited by 147 publications

References 50 publications

Sperm retrieval and live birth rates in presumed Sertoli‐cell‐only syndrome in testis biopsy: a single centre experience

Sperm retrieval and live birth rates in presumed Sertoli‐cell‐only syndrome in testis biopsy: a single centre experience

Clinical Potential and Putative Risks of Fertility Preservation in Children Utilizing Gonadal Tissue or Germline Stem Cells

Testis Kanserli Hastalarda Sperm Dondurma ve İnfertilite

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