Testicular seminoma presenting with gastric metastasis

Pollheimer, Verena S.; Gurakuqi, Gerald; Pollheimer, Marion J.; Beham‐Schmid, Christine; Langner, Cord

doi:10.1016/j.gie.2007.10.046

Cited by 4 publications

(4 citation statements)

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“…Eight previous reports comprising 14 patients describe gastrointestinal metastases as the presenting complaint of testicular malignancy, 1,4–10 typically involving the stomach, duodenum and jejunum—this case appears to be the first involving the ileum. Presenting symptoms were generally gastrointestinal bleeding, either major haemorrhage or occult chronic blood loss, as in this case.…”

Section: Figurementioning

confidence: 78%

Testicular seminoma metastases presenting as gastrointestinal malignancy: A case report and review of the literature

Thomson

Keong

Longano

et al. 2021

ANZ Journal of Surgery

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Section: Figurementioning

confidence: 78%

Testicular seminoma metastases presenting as gastrointestinal malignancy: A case report and review of the literature

Thomson

Keong

Longano

et al. 2021

ANZ Journal of Surgery

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“…Contrary to our case, most germ cell tumors with gastric metastasis have a nonseminoma component [ 6 ]. There are few reported cases of pure seminoma presenting at diagnosis with gastric metastases, both with and without macroscopic retroperitoneal ganglia involvement [ 7 , 8 , 9 ]. Most of these cases report a single gastric metastasis and some are associated with other visceral organ metastases, unlike our patient.…”

Section: Discussion/conclusionmentioning

confidence: 99%

Testicular Seminoma Presenting as Gastrointestinal Bleeding: A Rare Cause of Metastatic Disease in the Stomach

Silva

Leal

Ruge

et al. 2022

GE Port J Gastroenterol

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Introduction: Gastric metastases are quite infrequent. When arising from testicular germ cell tumors, gastric metastases are usually associated with nonseminomas. Case Report: A 45-year-old man presented with upper gastrointestinal bleeding, severe anemia, and elevated lactate dehydrogenase. Endoscopy revealed three atypical-looking gastric ulcers. Abdominal computed tomography showed an extensive heterogeneous retroperitoneal mass and a smaller one in the pelvis. Biopsies of both the ulcers and the retroperitoneal mass revealed a highly proliferative neoplasia of unknown origin. While the diagnostic work up was taking place, the patient complained of a testicular mass which was resected, after suspicious findings in the ultrasound. Histopathologic findings revealed a testicular seminoma. Revision of previous biopsies was compatible with metastatic seminoma to the stomach and the retroperitoneum. Discussion/Conclusion: Gastric metastasis arising from testicular seminoma is quite infrequent and usually diagnosed after the primary tumor is known. We report a rare case of a testicular seminoma presenting as upper gastrointestinal bleeding due to gastric metastases. This case highlights the importance of detailed anamnesis and physical examination in the differential diagnosis of atypical gastric ulcers with initial inconclusive work up and emphasizes an unusual manifestation of a germ cell malignancy.

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“…The most commonly reported cancers associated with gastric metastasis are breast, lung, renal and melanoma. 3 Published findings of gastric metastases arising from GCTs tend to be limited to single case reports (Table 1), [4][5][6][7][8][9][10] with some additional case reports of GCT metastasis to other areas of the GI tract. 18 Most reported cases of gastric metastases from GCTs are NSGCTs (Table 1), occur in the age range 15-35 (where incidence is highest), have retro-peritoneal lymph node involvement and visceral metastatic involvement of sites other than the gastric mucosa (often representing advanced disease).…”

Section: Discussionmentioning

confidence: 99%

“…2 Gastric metastases are a rare presentation of any solid malignancy 3 and have only been rarely reported in the setting of a germ cell primary (Table 1). [4][5][6][7][8][9][10] We present a case of a 67-year-old man, with a background of myelofibrosis, who was diagnosed with metastatic seminoma following an endoscopy for dyspepsia. Further investigation revealed isolated gastric mucosal disease as his sole extra-testicular site of disease.…”

Section: Introductionmentioning

confidence: 99%

Metastatic seminoma with isolated gastric metastases: a case report

et al. 2019

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Gastric metastases are a rare occurrence in patients with malignancy. In case reports of these arising from germ cell tumours, the majority were non-seminomatous germ cell tumours and had evidence of retroperitoneal involvement. We present a unique case of a 67-year-old man with metastatic testicular pure seminoma. He presented with dyspepsia and investigation found isolated metastases to the gastric mucosa and sub-mucosa from a right testicular primary. No lymph node involvement was identified. The patient was managed with curative intent with total gastrectomy and inguinal orchidectomy. To date, there is no evidence of disease recurrence.

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Testicular seminoma presenting with gastric metastasis

Cited by 4 publications

References 0 publications

Testicular seminoma metastases presenting as gastrointestinal malignancy: A case report and review of the literature

Testicular seminoma metastases presenting as gastrointestinal malignancy: A case report and review of the literature

Testicular Seminoma Presenting as Gastrointestinal Bleeding: A Rare Cause of Metastatic Disease in the Stomach

Metastatic seminoma with isolated gastric metastases: a case report

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