Testicular oxidative damage and role of combined antioxidant supplementation in experimental diabetic rats

Mohasseb, Magda; Ebied, Samia; Yehia, Mohamed; Hussein, Naglaa

doi:10.1007/s13105-010-0062-2

Cited by 62 publications

(48 citation statements)

References 37 publications

(33 reference statements)

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“…These observations led us to assume that a potent antioxidant is crucial in reducing the damage caused by oxidative stress. Some experimental, epidemiological and clinical studies also emphasize that antioxidants might be helpful for treating diabetes and its complication [10][11][12][13][14].…”

Section: Introductionmentioning

confidence: 99%

Effects of Pyrroloquinoline Quinone and Vitamin C on Diabetes Associated Testicular Dysfunction and Oxidative Damages in Testis of Streptozotocin-Induced Diabetic Mice: Histopathological Study

Kumar¹,

Kar²

2017

SOJPPS

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The aim of this study was to investigate the hitherto unknown potential of Pyrroloquinoline Quinone (PQQ) in regulating diabetes associated testicular dysfunctions and oxidative damages in testis of adult mice. Seven groups such as normoglycemic and PQQ treated controls; STZ-treated and STZ + PQQ treated (5, 10 and 20 mg/ kg/day, separately) and STZ + Vit.C (50 mg/kg) were established. After 18 days of experimentation, alterations in the markers of oxidative stress, various antioxidants, lipid profile, serum insulin, testosterone and testicular histology were evaluated. Administration of single dose of STZ (150 mg/kg b.wt) enhanced not only testicular lipid peroxidation and lipid hydroperoxides levels; but also serum concentration of glucose, cholesterol, triglyceride, low density lipid and very low density lipid; with a parallel decrease in serum insulin, testosterone, and different antioxidants in diabetic mice. However, on simultaneous administration of PQQ, particularly at a dose of 20 mg/kg, most of these adverse effects were ameliorated. While the PQQ (20 mg/kg) decreased the serum glucose by 50%, it increased insulin and testosterone levels by 59% and 169% respectively in STZinduced animals, these results suggest that PQQ may have potential to ameliorates diabetes-induced testicular dysfunction.

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Section: Introductionmentioning

confidence: 99%

Effects of Pyrroloquinoline Quinone and Vitamin C on Diabetes Associated Testicular Dysfunction and Oxidative Damages in Testis of Streptozotocin-Induced Diabetic Mice: Histopathological Study

Kumar¹,

Kar²

2017

SOJPPS

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“…[192021] Several studies have shown that antioxidant treatment improves glycemic index, reduces diabetic complications, and protects components from oxidative damage. [2223]…”

Section: Introductionmentioning

confidence: 99%

Modulation of diabetes-mellitus-induced male reproductive dysfunctions in experimental animal models with medicinal plants

Jain¹,

Jangir²

2014

Phcog Rev

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Today diabetes mellitus has emerged as a major healthcare problem throughout the world. It has recently broken the age barrier and has been diagnosed in younger people also. Sustained hyperglycemia is associated with many complications including male reproductive dysfunctions and infertility. Numerous medicinal plants have been used for the management of the diabetes mellitus in various traditional system of medicine and in folklore worldwide as they are a rich source of bioactive phytoconstituents, which lower blood glucose level and/or also act as antioxidants resulting in the amelioration of oxidative-stress-induced diabetic complications. The present review describes the ameliorative effects of medicinal plants or their products, especially on male reproductive dysfunctions, in experimental diabetic animal models.

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“…Suppressed testosterone secretion as a result of diminished Leydig cell function (Pitteloud et al, 2005) has been reported in T2DM. Decreased serum concentrations of reproductive hormones (testosterone, FSH and LH) have also been reported in DM animal models induced by STZ (Mohasseb et al, 2011;Kanter et al, 2013), alloxan (Hafez, 2010;Ghlissi et al, 2012) and nicotinamide+STZ (Ahangarpour et al, 2015), and in BB rats (Cameron et al, 1990). These studies show a unified pattern of events irrespective of the diabetic model used.…”

Section: Pre-testicular Effects Of Diabetes Mellitus (Hypothalamicpitmentioning

confidence: 78%

“…Studies with both T1 and T2 diabetic animal models have shown significant decreases in antioxidant enzymes and a significant increase in lipid peroxidation in the testis. Reports from studies using STZ-induced T1DM rats have shown significant decreases in testicular superoxide dismutase (SOD), catalase (CAT) and glutathione peroxidase (GPx) activities, and a significant increase in malondialdehyde (MDA) level (Mohasseb et al, 2011;Kanter et al, 2013).…”

Section: Testicular Oxidative Stressmentioning

confidence: 99%

“…Mohasseb et al (2011) have reported an increased activity of the executioner caspase (caspase-3) in the testis of STZ-induced diabetic rats. Upregulation of the pro-apoptotic protein (Bax) and down-regulation of the anti-apoptotic protein (Bcl-2) have been reported in T1 (Ghosh et al, 2014) and T2 (Long et al, 2015) diabetic rats, with an increase in expression of caspases 8 and 3 (Jiang et al, 2013) in T1 diabetic rats.…”

Section: Testicular Histology and Germ Cell Apoptosis In Diabetes Melmentioning

confidence: 99%

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Diabetes mellitus-induced male reproductive impairment: The role of natural products: A review

2017

J App Pharm Sci

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Diabetes mellitus (DM) is a metabolic disorder characterized by persistent hyperglycaemia, with multi-organ complications. DM is known to trigger oxidative stress in virtually all tissues of the body including male reproductive organs. Several experimental and clinical studies have reported varying degrees of male reproductive impairment in DM. Disruption in the hypothalamic-pituitary-gonadal axis, abnormal testicular energy metabolism, testicular and epididymal oxidative stress and oxidative stress-induced germ cell apoptosis have been reported in DM. The use of natural products in the treatment of various diseases is gaining more attention in experimental and clinical studies for the management and/or treatment of various diseases. In this review, the effects of DM on male reproductive system at pre-testicular, testicular and post-testicular levels are discussed. The role of various natural products including whole plant extracts and some pure compounds isolated from plants, with their suggested mechanism of actions is also reviewed.

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Testicular oxidative damage and role of combined antioxidant supplementation in experimental diabetic rats

Cited by 62 publications

References 37 publications

Effects of Pyrroloquinoline Quinone and Vitamin C on Diabetes Associated Testicular Dysfunction and Oxidative Damages in Testis of Streptozotocin-Induced Diabetic Mice: Histopathological Study

Effects of Pyrroloquinoline Quinone and Vitamin C on Diabetes Associated Testicular Dysfunction and Oxidative Damages in Testis of Streptozotocin-Induced Diabetic Mice: Histopathological Study

Modulation of diabetes-mellitus-induced male reproductive dysfunctions in experimental animal models with medicinal plants

Diabetes mellitus-induced male reproductive impairment: The role of natural products: A review

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