Testicular Metastasis in a Case of Squamous Cell Carcinoma of the Lung

Buck, Dennis Andrew; Byrd, Robert H.; Holmes, Cynthia L.; Pollock, Theodore

doi:10.1159/000380814

Cited by 15 publications

(11 citation statements)

References 8 publications

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“…Testicular neoplasms account for only 1% of all malignancies, and the majority of testicular neoplasms are primary tumors. 8 There are no specific characteristics of metastatic testicular tumors on imaging data. Metastatic tumors usually present as solitary, unilateral nodules and may mimic primary neoplasms of the testis.…”

Section: Discussionmentioning

confidence: 99%

“…11 Various metastatic routes, including direct invasion, retrograde venous embolism, arterial embolization, retrograde lymphatic extension from para-aortic lymph nodes, transperitoneal seeding and retrograde extension from the vas deferens, have been described as leading to the development of testicular metastasis. 8 The most common mechanism of tumor spread in urothelial carcinoma (UC) is the lymphovascular system. 1 However, the molecular mechanisms of the blood-testis and blood-epididymis barriers for preventing metastatic spread to the testis and how metastases overcome these protective mechanisms remain unclear.…”

Section: Discussionmentioning

confidence: 99%

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<p>Testicular Metastasis from Urothelial Carcinoma of the Renal Pelvis: A Rare Case and Review of the Literature</p>

Zhang

et al. 2020

OTT

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This paper presents an extremely rare case of testicular metastasis arising from renal pelvis carcinoma. The testicle is a rare site of clinically detectable tumor metastasis, originating rarely from upper tract urothelial carcinoma (UTUC). There are only two cases concerning UTUC metastasis to the testis available in the literature. In this report, we presented a patient who developed serial testicle, lung, liver and retroperitoneal lymph node metastasis from primary urothelial carcinoma of the renal pelvis within one year after surgery and chemotherapy. In conclusion, for patients with a history of UTUC who present with testicular symptoms, clinicians should be highly alert for the possibility of malignant involvement at this site.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

<p>Testicular Metastasis from Urothelial Carcinoma of the Renal Pelvis: A Rare Case and Review of the Literature</p>

Zhang

et al. 2020

OTT

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“…These functions may make invasion and proliferation of metastatic tumor cells difficult. Furthermore, there are two case reports of testicular metastasis of SCC from the lung [8, 9]. Hence, it is important to determine whether the tumor is a primary tumor and other neoplasms should be excluded.…”

Section: Discussionmentioning

confidence: 99%

Squamous Cell Carcinoma Developing from a Testicular Epidermal Cyst: A Case Report and Literature Review

Kasahara

Tajiri

Kobayashi

et al. 2019

Case Reports in Urology

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A 50-year-old Japanese man with a two-year history of a painless right scrotal mass visited our hospital. Considering laboratory findings and computed tomography, the patient was diagnosed with an uncharacteristic testicular tumor. No metastases were present on radiographic study at the first visit. Emergent high radical orchiectomy was performed, and the tumor was identified as a squamous cell carcinoma (SCC) of a testicular epidermal cyst. He is alive without recurrence or metastasis six months after surgery. Testicular SCC is an extremely rare tumor. This is the third case of testicular SCC associated with an epidermal cyst in English literature.

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“…Both adenocarcinoma and squamous cell carcinoma of the lung have been reported metastatic to the testis. [24][25][26][27] On gross examination, the tumors are usually solitary gray-tan intraparenchymal masses. On microscopic examination, adenocarcinoma involves the intertubular spaces of the testis, with papillary, micropapillary, acinar, mucinous or poorly differentiated patterns.…”

Section: Metastatic Lung Carcinomamentioning

confidence: 99%

Metastatic Carcinoma to the Testis - A Mini Review

Wang¹

2019

J Rare Dis Res Treat

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Metastatic carcinomas to the testis are extremely rare and have been reported only in autopsy series or case reports. However, when they occur, the metastatic tumors in the testis are usually unilateral and solitary, may have overlap growth patterns and cytological features with primary testicular tumors, including those of rete/epididymis origin, mesothelial origin and Sertoli cell tumor. It will make the diagnosis very challenging, especially when there is no known history of a primary tumor in other sites. Metastatic prostatic adenocarcinoma counts nearly half of the overall metastatic carcinoma in the testis, followed by colorectal carcinoma and renal cell carcinoma. Here, we review our experience and summarize the reported cases from the literature, to emphasize some of the unusual aspects of metastatic carcinoma to the testis, and discuss the main differential diagnoses for this rare condition. Awareness of the features of these tumors, consideration of the possibility of metastasis and appropriate ancillary studies are the keys to the accurate diagnosis of these cases.

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Testicular Metastasis in a Case of Squamous Cell Carcinoma of the Lung

Cited by 15 publications

References 8 publications

<p>Testicular Metastasis from Urothelial Carcinoma of the Renal Pelvis: A Rare Case and Review of the Literature</p>

<p>Testicular Metastasis from Urothelial Carcinoma of the Renal Pelvis: A Rare Case and Review of the Literature</p>

Squamous Cell Carcinoma Developing from a Testicular Epidermal Cyst: A Case Report and Literature Review

Metastatic Carcinoma to the Testis - A Mini Review

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