Testicular metastasis as the first clinical manifestation of pancreatic adenocarcinoma: a case report

Cormio, Luigi; Sanguedolce, Francesca; Massenio, Paolo; Fino, Giuseppe Di; Bruno, Mariantonietta; Carrieri, Giuseppe

doi:10.1186/s13256-015-0626-4

Cited by 12 publications

(15 citation statements)

References 15 publications

(20 reference statements)

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“…Kiefer[ 3 ] first described epididymal spread originating from primary pancreatic cancer, which was incidentally discovered during autopsy in 1927[ 3 ]. To date, less than 30 cases have been reported including 1from China[ 4 ], 2from South Korea[ 5 , 6 ], 10from Japan[ 7 ], 6from the United States[ 8 - 12 ], and the other 5from European countries[ 13 - 17 ]. Scrotal or inguinal metastases occur worldwide, although Japanese males have a much higher incidence, accounting for half of the published cases.…”

Section: Discussionmentioning

confidence: 99%

“…Only 3 cases experienced weight loss or other digestive discomfort[ 8 , 14 , 16 ]. One patient was referred due to severe acute pain in the right testis[ 13 ] and may have been diagnosed as orchitis. Kim et al [ 6 ] and colleagues reported a case of metastatic testicular tumor from pancreas, whose only initial symptom was hydrocele[ 6 ].…”

Section: Discussionmentioning

confidence: 99%

“…But it has been widely recognized that the main routes include arterial embolization, transperitoneal seeding through tunica vaginalis. In our review, pancreatic tumors metastasizing to the testis were found in 5 (31%) of the 16 confirmed cases[ 4 , 9 , 10 , 13 , 16 ], and 1of them invaded the epididymis[ 9 ]. Meanwhile, the tumors metastasizing to paratestis were reported in 11 cases[ 5 - 8 , 11 , 12 , 14 , 15 , 17 ], of which 4 involved the tunica vaginalis rather than testis[ 6 , 8 , 11 ], and 6 cases invaded the spermatic cord and/or epididymis [ 5 , 7 , 12 , 14 , 15 , 17 ].…”

Section: Discussionmentioning

confidence: 99%

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Tunica vaginalis testis metastasis as the first clinical manifestation of pancreatic adenocarcinoma: A case report

Zhang¹,

Ma²,

Gao³

et al. 2021

WJCC

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BACKGROUND Metastases from pancreas or ampullary malignancies are common, but the spread to testicle and paratesticular tissue is exceedingly rare. To the best of our knowledge, fewer than 30 cases have been reported in the literature. More rarely, metastasis to tunica vaginalis testis occurs without involvement of the testes and epididymis. CASE SUMMARY A 65-year-old male who complained of painless swelling of the left scrotum for over 1 wk was referred to the Department of Urology. Scrotal ultrasound showed left testicular hydrocele with paratesticular masses. Chest computed tomography revealed lung metastasis and enlarged left supraclavicular lymph node.The blood tumor markersalpha-fetoprotein, human chorionic gonadotropin, and serum lactate dehydrogenase were withinnormal limits.The preoperative diagnosis was left testicular tumor with lung metastasis. Then radical orchidectomy of the left testicle and high ligation of the spermatic cord were performed, and postoperative histopathology suggested metastatic tumors that was confirmed by an abdominal computed tomographic scan. The positive computed tomography findings, in conjunction with the expression of cytokeratin 7 (CK7), CK20, CK5/6, and absence of expression of Wilms’ tumor suppressor gene 1, calretinin, melanocyte, prostate-specific antigen, thyroid transcription factor-1, GATA binding protein 3, caudal type homeobox 2, and napsinA supported the diagnosis of pancreatic adenocarcinoma. The outcome of this patient was unsatisfactory, and he died 3 mo later. CONCLUSION This case suggests that pancreatic metastatic carcinoma must be considered in the differential diagnosis of scrotal enlargement. The advanced age of the patient wassuggestive of a secondary testicular tumor.In addition, careful physical examination and ultrasonography as well as radiological examination have become a standard modality.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Tunica vaginalis testis metastasis as the first clinical manifestation of pancreatic adenocarcinoma: A case report

Zhang¹,

Ma²,

Gao³

et al. 2021

WJCC

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“…Lung metastasis is quite common, while secondary neoplasia of testicular cancers from solid tumors, except for leukemia and lymphoid carcinoma, is extremely rare, accounting for only 0.02% to 3.6% of all testicular neoplastic lesions. 3 Metastatic involvement of the testicle by UTUC is even rarer. Testicular metastasis is generally found occasionally during orchiectomy for prostate cancer or at autopsy.…”

Section: Discussionmentioning

confidence: 99%

<p>Testicular Metastasis from Urothelial Carcinoma of the Renal Pelvis: A Rare Case and Review of the Literature</p>

Zhang

et al. 2020

OTT

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This paper presents an extremely rare case of testicular metastasis arising from renal pelvis carcinoma. The testicle is a rare site of clinically detectable tumor metastasis, originating rarely from upper tract urothelial carcinoma (UTUC). There are only two cases concerning UTUC metastasis to the testis available in the literature. In this report, we presented a patient who developed serial testicle, lung, liver and retroperitoneal lymph node metastasis from primary urothelial carcinoma of the renal pelvis within one year after surgery and chemotherapy. In conclusion, for patients with a history of UTUC who present with testicular symptoms, clinicians should be highly alert for the possibility of malignant involvement at this site.

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“…Kiefer ED first described metastatic epididymal spread from primary pancreatic carcinoma in 1927 as an incidental autopsy finding [3]. To date, less than 30 cases have been reported, including one from China [4], two from South Korea [5][6], ten from Japan [7], six from the USA [8][9][10][11][12] and the other five from European countries [13][14][15][16][17]. The scrotal or inguinal metastasis propensity occurs world-wide, although there is a remarkably high incidence among Japanese men, who account for one harf of published cases.…”

Section: Discussionmentioning

confidence: 99%

The Tunica vaginalis testis metastasis as the first clinical manifestation of pancreatic adenocarcinoma: a case report and and literature review

zhang

Guo

ma³

et al. 2020

Preprint

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Background: Metastases from pancreas or ampullary malignancies are common, but spread to the testicle and paratesticular tissue is exceedingly rare. To our knowledge, few than 30 cases have been previously reported in the literature. More rarely, it is to be found with tunica vaginalis testis metastasis without involvement of testicle and epididymis. Case presentation: A 65-year-male with complaints of left painless scrotal swellings for over 1 week was referred to the Department of Urology . Scrotal ultrasound demonstrated a left sided hydrocele with paratesticular masses.The chest computed tomography showed lung metastases and left enlarged supraclavicular lymph node. The preoperative diagnosis was left testicular tumor with lung metastasis.Then, a left radical orchidectomy was performed with high ligation of the spermatic cord and postoperative histopathology showed that it was suggestive of metastatic tumors. Abdominal computed tomography revealed the presence of a tumor in the tail of the pancreas. Tumor markers cancer antigen CA 19-9 were elevated almost 6-fold levels. The outcome of this patient was unsatisfactory and died 3 months later. Conclusions: This case highlighted that metastatic carcinoma from the pancreas must be considered in the differential diagnosis of scrotal enlargement. Older patient age is suggestive of a secondary testicular tumor. In addition, careful clinical and radiological examination has become the imaging modality.

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Testicular metastasis as the first clinical manifestation of pancreatic adenocarcinoma: a case report

Cited by 12 publications

References 15 publications

Tunica vaginalis testis metastasis as the first clinical manifestation of pancreatic adenocarcinoma: A case report

Tunica vaginalis testis metastasis as the first clinical manifestation of pancreatic adenocarcinoma: A case report

<p>Testicular Metastasis from Urothelial Carcinoma of the Renal Pelvis: A Rare Case and Review of the Literature</p>

The Tunica vaginalis testis metastasis as the first clinical manifestation of pancreatic adenocarcinoma: a case report and and literature review

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