Testicular Leydig cell tumor in a 64-year old man with cytological high grade features and no metastasis

Crabtree, Matthew; Cheng, Doris; Barajas, Luciano

doi:10.1016/j.ehpc.2020.200464

Cited by 1 publication

(2 citation statements)

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“…LCT is a rare non-germ cell tumor that may be solitary tumor or associated with different types of germ cell tumors. It develops in prepubertal age and third to sixth decades of life [3] . Feminization, infertility, undesired sexual behavior, testicle degeneration, and many other factors aggregate with LCT [4] .…”

Section: Discussionmentioning

confidence: 99%

“…It mostly affects the prepubertal males and men in the third to sixth decades of life. This tumor is usually identified as a benign tumor, but malignancy is possible in 10% of adult patients with a poor prognosis [3] . The clinical presentations are variable ranging from asymptomatic to feminization, pubic hair growth, enlargement of the genital organ, and voice change in the prepubertal stage while gynecomastia, undesired sexual behavior, infertility, and impotence may be the presenting symptoms in adult patients [4] .…”

Section: Introductionmentioning

confidence: 99%

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Simultaneous Sertoli Cell-Only Syndrome and Leydig Cell Tumor in a Patient with Azoospermia: A Rare Case Report

Bapir

Salih

et al. 2022

Case Rep Oncol

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Testicular cancers comprise 1–1.5% of entire cancers in men, and sex cord-stromal tumors include 5% of testicular cancers. This study aims to report a simultaneous Sertoli cell-only syndrome and Leydig cell tumor in the same patient. A 32-year-old man presented with a history of primary infertility for 3 years. Physical examination revealed normal secondary sexual characteristics. Two successive seminal fluid analyses revealed azoospermia. A scrotal ultrasound scan showed a 28 × 27 mm hypoechoic and hypervascular right testicular mass. Right radical orchiectomy and simultaneous left testicular biopsy were conducted. The histopathological examination revealed Sertoli cell-only syndrome and Leydig cell tumor with focal Leydig cell hyperplasia. Reversing fertility following the management of Leydig cell tumor is rarely mentioned in the literature. A study revealed that fertility recovered following 4 months of management in a primary infertile male. However, infertile men with nonobstructive azoospermia due to SCOS can only have a child by testicular sperm extraction technique. Despite the rare occurrence of Leydig cell tumor, it could be seen in association with Sertoli cell-only syndrome in infertile men with azoospermia. Clinical examination and imaging studies are important in these patients as the possibility of having a testicular mass is high among them.

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Section: Discussionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%