Testicular infection in brucellosis: Report of 34 cases

Bosilkovski, Mile; Kamiloski, Viktor; Miskova, Silvana; Balalovski, Danco; Kotevska, Vesna; Petrovski, Mile

doi:10.1016/j.jmii.2016.02.004

Cited by 25 publications

(20 citation statements)

References 29 publications

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“…Clinically it can manifest differently and can affect any organ system. The most common, genitourinary presentation is brucellosis epididymo-orchitis (BEO), which in endemic areas have been reported to account for 1.6%–12.7% of brucellosis 3. These can occur at any stage of the disease, either as the initial presentation or as a late complication.…”

Section: Introductionmentioning

confidence: 99%

Acute epididymo-orchitis frombrucellosis melitensisin Australia

Ip¹,

Tumali

Hoh

et al. 2019

BMJ Case Rep

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Brucellosis epididymo-orchitis (BEO) is extremely rare in non-endemic areas such as Australia. While epididymo-orchitis is relatively common in adolescent men, when presented with a significant travel history, consideration should be given to rare causes such as this. Here, we present a case of BEO in a young 18-year-old man who recently migrated from Greece, with symptoms of acute scrotal pain, swelling and persistent fever. Brucella melitensis was isolated in the blood culture and confirmed with PCR. We suspect transmission was related to ingestion of unpasteurised goat dairy products. He made a full recovery after 7 days of intravenous gentamicin and 6 weeks of oral doxycycline. BEO should be considered in those who present with acute scrotal pain and fever after a recent history of travel to or from a brucellosis- endemic area.

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Section: Introductionmentioning

confidence: 99%

Acute epididymo-orchitis frombrucellosis melitensisin Australia

Ip¹,

Tumali

Hoh

et al. 2019

BMJ Case Rep

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“…In these data, although 19 patients had a clear history of contact with cattle and sheep, this information is often neglected in the process of epidemiological data collection, which may lead to misdiagnosis and missed diagnosis. A published study 3 showed that even in endemic areas, it is difficult for doctors to diagnose brucellosis when the patient only shows orchitis. Through this study, we found that most of the patients came from farming and pastoral areas.…”

Section: Discussionmentioning

confidence: 99%

Brucellar reproductive system injury: A retrospective study of 22 cases and review of the literature

et al. 2020

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Objective We aimed to describe the clinical characteristics and prognosis of 22 patients with Brucella-induced reproductive system injury. Methods We assessed 22 patients with reproductive system injury between 2010 and 2018 at The First Affiliated Hospital of Xinjiang Medical University. Results The disease is predominant in men. Male patients had orchitis, erectile dysfunction, prostatitis, and urethral stricture, while female patients had vaginitis and cervicitis. Some patients had laboratory abnormalities and liver injury. Patients received combination therapy of rifampicin and doxycycline. Doxycycline combined with levofloxacin or moxifloxacin was administered to patients with rifampicin intolerance. All patients had received antibiotic therapy for at least 6 weeks. One patient was lost to follow-up, one patient relapsed because of osteoarthropathy, and one patient had dysuria resulting from chronic prostatitis. The clinical symptoms resolved in the other patients, and the overall patient prognosis was good. Conclusion Clinicians should pay attention to brucellosis-induced reproductive system damage. The two-drug regimen of rifampicin+doxycycline is recommended for these patients. Doxycycline combined with levofloxacin or moxifloxacin should be used in patients with brucellosis-induced reproductive system damage who have rifampicin intolerance. The treatment course should be at least 6 weeks.

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“…BEO'lu olguların yaklaşık %10'unda ise bilateral tutulum gözlenmektedir. [8] Literatürle uyumlu olarak yaş ortalaması 33 yıl olan BEO'lu olgularımızın tamamında unilateral testis tutulumu gözledik. Skrotal ağrı ve şişlik BEO'lu olgularda en sık görülen semptomlardır.…”

Section: Discussionunclassified

Brusellozun ilk manifestasyonu olarak ortaya çıkan epididimo-orşit olgularının semptom ve bulguları non-spesifik epididimo-orşitten farklı mıdır?

Efesoy¹,

Saylam²,

Çayan³

2018

Androl Bul

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Bruselloz, hayvanlardan insanlara bulaşan, çeşitli doku ve organları tutan, hafif belirtilerden ağır klinik tablolara kadar seyredebilen, belirti ve bulguları spesifik olmayan ve bu nedenlerle birçok hastalığı taklit edebilen sistemik bir hastalıktır. Dünya Sağlık Örgütü (DSÖ) verilerine göre dünyada en sık rastlanan bakteriyel zoonoz olan bruselloz ABSTRACT OBJECTIVE: Brucella epididymo-orchitis as the first presenting sign of brucellosis (BEO) is difficult to separate from non-specific epididymo-orchitis (NSEO). In these cases, delayed diagnosis and treatment causes testicular damage that may lead to infertility and orchiectomy. The aim of this study was to investigate whether or not the clinical, laboratory and radiological findings of BEO different from NSEO. MATERIAL and METHODS: In this retrospective study, we evaluated the medical records of 164 patients who diagnosed with epididymo-orchitis in our clinic between January 2010 and June 2018. The diagnosis of epididymo-orchitis was based on clinical and laboratory findings and ultrasonographic examination. High agglutination titers (≥1/160) and/or positive blood cultures were accepted as the main criteria for the diagnosis of brucellosis. Five patients who were previously diagnosed as brucellosis were excluded from the study and the clinical, laboratory and radiological findings of 9 cases of BEO were compared with 34 NSEO cases in the same age group. RESULTS: The mean age of cases at diagnosis was 33.44±9.81 and 34.76±10.09 in the BEO and NSEO groups, respectively (p=0.728). There were no significant differences between two groups in terms of clinical, laboratory and radiological findings, except one. Risk factors for brucella were detected in 8 (88.9%) of BEO group and in 5 (14.7%) of NSEO group (p<0.001). Although not statistically significant but at the level of borderline significant trend, it was found that the ratio of arthralgia and serum CRP levels >5 mg/dL more frequent in BEO group and the ratio of dysuria, pyuria and leukocytosis more frequent NSEO group (p values 0.073, 0.089, 0.069, 0.069 and 0.058, respectively). CONCLUSION: Brucellosis should be kept in mind in patients with epididymoorchitis and the risk factors for brucellosis should be questioned in these patients. In addition, in patients with epididymo-orchitis with arthralgia without dysuria, pyuria and leukocytosis should more be paid attention to the differential diagnosis of BEO.

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Testicular infection in brucellosis: Report of 34 cases

Cited by 25 publications

References 29 publications

Acute epididymo-orchitis frombrucellosis melitensisin Australia

Acute epididymo-orchitis frombrucellosis melitensisin Australia

Brucellar reproductive system injury: A retrospective study of 22 cases and review of the literature

Brusellozun ilk manifestasyonu olarak ortaya çıkan epididimo-orşit olgularının semptom ve bulguları non-spesifik epididimo-orşitten farklı mıdır?

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