Testicular induced corticosterone synthesis in male rats under fasting stress

Maeda, Naoyuki; Fujiki, Jumpei; Hasegawa, Yasuhiro; Ieko, Takahiro; Miyasho, Taku; Iwasaki, Tomohito; Yokota, Hiroshi

doi:10.1016/j.steroids.2021.108947

Cited by 8 publications

(2 citation statements)

References 42 publications

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“…Progesterone is the first hormone generated in the steroidogenesis process because pregnenolone is regarded as a precursor of steroid hormones and is created from cholesterol by the action of cytochrome P450scc in the mitochondria. It is converted from pregnenolone by the 3β-HSD enzyme in the smooth endoplasmic reticulum [81]. Because we found a significant effect of all of the BPA analogs we tested and BPA itself on the production of progesterone by human adrenocarcinoma cells, we believe that bisphenols disrupt these enzymes.…”

Section: Progesteronementioning

confidence: 81%

Comparison of the Effect of BPA and Related Bisphenols on Membrane Integrity, Mitochondrial Activity, and Steroidogenesis of H295R Cells In Vitro

Štefunková,

Greifová,

Jambor

et al. 2023

Life

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Bisphenol A (BPA) is an endocrine-disruptive chemical that is widely utilized in the production of polycarbonate plastic and epoxy resin, which are used to make a wide range of consumer products, food and drink containers, and medical equipment. When the potential risk of BPA emerged, it was substituted by allegedly less harmful substitutes such as bisphenols S, F, B, and AF. However, evidence suggests that all bisphenols can have endocrine-disruptive effects, while the extent of these effects is unknown. This study aimed to determine effect of BPA, BPAF, BPB, BPF, and BPS on viability and steroidogenesis in human adrenocortical carcinoma cell line in vitro. The cytotoxicity of bisphenols was shown to be considerable at higher doses. However, at low concentrations, it improved viability as well as steroid hormone secretion, indicating that bisphenols have a biphasic, hormetic effect in biological systems. The results are consistent with the hypothesis that bisphenols selectively inhibit some steroidogenic enzymes. These findings suggest that bisphenols have the potential to disrupt cellular steroidogenesis in humans, but substantially more detailed and systematic research is needed to gain a better understanding of the risks associated with bisphenols and their endocrine-disrupting effect on humans and wildlife.

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Section: Progesteronementioning

confidence: 81%

Comparison of the Effect of BPA and Related Bisphenols on Membrane Integrity, Mitochondrial Activity, and Steroidogenesis of H295R Cells In Vitro

Štefunková,

Greifová,

Jambor

et al. 2023

Life

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“…ACTH then activates the adrenal glands to release glucocorticoids, which play a significant role in the metabolic response to undernutrition by causing an increased release of amino acids from skeletal muscle and their subsequent conversion to glucose in the liver [32][33][34]. Increased levels of plasma ACTH and glucocorticoids during fasting have been found in humans [35,36] and rodents [34,37,38]. Given that GREs in the KLF15 gene are critical for the fasting response and are highly conserved across various mammalian species (Fig.…”

Section: (E-g)mentioning

confidence: 99%

GR‐KLF15 pathway controls hepatic lipogenesis during fasting

Takeuchi,

Murayama,

Aita

et al. 2023

The FEBS Journal

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During periods of fasting, the body undergoes a metabolic shift from carbohydrate utilization to the use of fats and ketones as an energy source, as well as the inhibition of de novo lipogenesis and the initiation of gluconeogenesis in the liver. The transcription factor sterol regulatory element‐binding protein‐1 (SREBP‐1), which plays a critical role in the regulation of lipogenesis, is suppressed during fasting, resulting in the suppression of hepatic lipogenesis. We previously demonstrated that the interaction of fasting‐induced Kruppel‐like factor 15 (KLF15) with liver X receptor serves as the essential mechanism for the nutritional regulation of SREBP‐1 expression. However, the underlying mechanisms of KLF15 induction during fasting remain unclear. In this study, we show that the glucocorticoid receptor (GR) regulates the hepatic expression of KLF15 and, subsequently, lipogenesis through the KLF15‐SREBP‐1 pathway during fasting. KLF15 is necessary for the suppression of SREBP‐1 by GR, as demonstrated through experiments using KLF15 knockout mice. Additionally, we show that GR is involved in the fasting response, with heightened binding to the KLF15 enhancer. It has been widely known that the hypothalamic–pituitary–adrenal (HPA) axis regulates the secretion of glucocorticoids and plays a significant role in the metabolic response to undernutrition. These findings demonstrate the importance of the HPA‐axis‐regulated GR‐KLF15 pathway in the regulation of lipid metabolism in the liver during fasting.

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Aldicarb disturbed bile acid, steroid hormone and oxylipin homeostasis in C57BL/6 J mice

Liu,

Tu,

Zhang

et al. 2024

Ecotoxicology and Environmental Safety

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Testicular induced corticosterone synthesis in male rats under fasting stress

Cited by 8 publications

References 42 publications

Comparison of the Effect of BPA and Related Bisphenols on Membrane Integrity, Mitochondrial Activity, and Steroidogenesis of H295R Cells In Vitro

Comparison of the Effect of BPA and Related Bisphenols on Membrane Integrity, Mitochondrial Activity, and Steroidogenesis of H295R Cells In Vitro

GR‐KLF15 pathway controls hepatic lipogenesis during fasting

Aldicarb disturbed bile acid, steroid hormone and oxylipin homeostasis in C57BL/6 J mice

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Testicular induced corticosterone synthesis in male rats under fasting stress

Cited by 8 publications

References 42 publications

Comparison of the Effect of BPA and Related Bisphenols on Membrane Integrity, Mitochondrial Activity, and Steroidogenesis of H295R Cells In Vitro

Comparison of the Effect of BPA and Related Bisphenols on Membrane Integrity, Mitochondrial Activity, and Steroidogenesis of H295R Cells In Vitro

GR‐KLF15 pathway controls hepatic lipogenesis during fasting

Aldicarb disturbed bile acid, steroid hormone and oxylipin homeostasis in C57BL/6 J mice

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Product

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About

Aldicarb disturbed bile acid, steroid hormone and oxylipin homeostasis in C57BL/6 J mice